Published in Cell on July 07, 2011
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science (2012) 4.14
Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell (2013) 2.98
Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev (2011) 2.48
Understanding cancer stem cell heterogeneity and plasticity. Cell Res (2012) 2.39
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature (2016) 2.27
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion. Cell (2015) 2.20
Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. Cancer Cell (2014) 2.14
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer (2014) 2.10
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci (2013) 1.98
Genome-wide consequences of deleting any single gene. Mol Cell (2013) 1.76
A neurocentric perspective on glioma invasion. Nat Rev Neurosci (2014) 1.61
Paediatric and adult malignant glioma: close relatives or distant cousins? Nat Rev Clin Oncol (2012) 1.58
Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. PLoS Biol (2016) 1.49
Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. Cancer Cell (2015) 1.49
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell (2016) 1.49
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene (2011) 1.38
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes Dev (2012) 1.30
MAPK pathway activation in pilocytic astrocytoma. Cell Mol Life Sci (2011) 1.28
Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell (2012) 1.26
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A (2014) 1.12
Luminal cells are favored as the cell of origin for prostate cancer. Cell Rep (2014) 1.12
Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci (2013) 1.11
Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep (2014) 1.07
Extensions of MADM (mosaic analysis with double markers) in mice. PLoS One (2012) 1.06
The NF-κB RelB protein is an oncogenic driver of mesenchymal glioma. PLoS One (2013) 1.04
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol (2012) 1.04
Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma. J Transl Med (2011) 1.03
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat Cell Biol (2013) 1.03
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival. Clin Cancer Res (2012) 1.03
The cellular origin for malignant glioma and prospects for clinical advancements. Expert Rev Mol Diagn (2012) 1.02
Glioblastoma-initiating cells: relationship with neural stem cells and the micro-environment. Cancers (Basel) (2013) 1.01
Role of SOX family of transcription factors in central nervous system tumors. Am J Cancer Res (2014) 1.01
NG2 cells (polydendrocytes) in brain physiology and repair. Front Neurosci (2014) 1.01
Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years. Neuron (2013) 1.00
High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports (2013) 0.99
Ribosome profiling reveals a cell-type-specific translational landscape in brain tumors. J Neurosci (2014) 0.99
Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells. Proc Natl Acad Sci U S A (2012) 0.98
MASTR: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice. Cell Rep (2012) 0.97
Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int (2014) 0.96
The roots of cancer: stem cells and the basis for tumor heterogeneity. Bioessays (2012) 0.96
Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas. Oncotarget (2011) 0.95
Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process. Proc Natl Acad Sci U S A (2014) 0.95
Notching on Cancer's Door: Notch Signaling in Brain Tumors. Front Oncol (2015) 0.95
Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes. Cell Rep (2013) 0.93
The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol (2012) 0.93
Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression. Oncotarget (2015) 0.93
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest (2014) 0.93
On the origin of glioma. Ups J Med Sci (2012) 0.92
The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression. Cancer Res (2014) 0.92
Regulation of glioblastoma multiforme stem-like cells by inhibitor of DNA binding proteins and oligodendroglial lineage-associated transcription factors. Cancer Sci (2012) 0.91
CDC20 maintains tumor initiating cells. Oncotarget (2015) 0.90
Fine-Tuning Oligodendrocyte Development by microRNAs. Front Neurosci (2012) 0.89
Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep (2013) 0.89
Developmental origins of brain tumors. Curr Opin Neurobiol (2012) 0.89
Contribution of tumor heterogeneity in a new animal model of CNS tumors. Mol Cancer Res (2014) 0.88
Glioma development: where did it all go wrong? Cell (2011) 0.88
Brain stem cells as the cell of origin in glioma. World J Stem Cells (2014) 0.88
Studying a complex tumor: potential and pitfalls. Cancer J (2012) 0.87
Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development (2013) 0.87
NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma. Oncogene (2013) 0.87
Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol (2013) 0.87
Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors. Development (2014) 0.86
Cell polarity in morphogenesis and metastasis. Philos Trans R Soc Lond B Biol Sci (2013) 0.86
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun (2015) 0.86
Cell of origin for malignant gliomas and its implication in therapeutic development. Cold Spring Harb Perspect Biol (2015) 0.85
Epigenetic pathways and glioblastoma treatment. Epigenetics (2013) 0.85
A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain. Stem Cell Reports (2015) 0.85
Personalized medicine for gliomas. Surg Neurol Int (2015) 0.85
Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation. Oncoscience (2014) 0.84
Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells. Oncotarget (2016) 0.84
Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males. J Clin Invest (2014) 0.84
Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain. Neural Dev (2012) 0.84
Characterization of fluorescent eye markers for mammalian transgenic studies. PLoS One (2011) 0.84
Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling. Neuro Oncol (2014) 0.83
Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers. PLoS Comput Biol (2014) 0.83
Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol (2011) 0.83
MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours. Stem Cells Int (2015) 0.82
Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration. Brain Res (2015) 0.82
Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy. Int J Mol Sci (2016) 0.81
Contemporary murine models in preclinical astrocytoma drug development. Neuro Oncol (2014) 0.81
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem (2013) 0.81
The probable cell of origin of NF1- and PDGF-driven glioblastomas. PLoS One (2011) 0.81
Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer. Mol Ther (2012) 0.81
What underlies the diversity of brain tumors? Cancer Metastasis Rev (2013) 0.81
A pseudogene-signature in glioma predicts survival. J Exp Clin Cancer Res (2015) 0.81
PRG3 induces Ras-dependent oncogenic cooperation in gliomas. Oncotarget (2016) 0.80
Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res (2014) 0.80
Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. Oncotarget (2012) 0.80
Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance. Stem Cells Int (2016) 0.80
Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers. J Physiol (2012) 0.80
Review: insights gained from modelling high-grade glioma in the mouse. Neuropathol Appl Neurobiol (2012) 0.80
Glioma revisited: from neurogenesis and cancer stem cells to the epigenetic regulation of the niche. J Oncol (2012) 0.80
Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. Neuro Oncol (2016) 0.80
Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol (2013) 0.79
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell (1999) 15.87
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
Cells of origin in cancer. Nature (2011) 6.85
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature (2005) 6.40
hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis (2001) 6.29
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Mosaic analysis with double markers in mice. Cell (2005) 5.32
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell (2001) 4.98
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science (2000) 4.65
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 4.47
NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development (2007) 4.21
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci (2003) 3.69
Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med (2003) 3.56
A new transgene reporter for in vivo magnetic resonance imaging. Nat Med (2005) 2.85
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature (2002) 2.74
Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J Neurosci (2006) 2.43
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene (2009) 1.96
Non-stem cell origin for oligodendroglioma. Cancer Cell (2010) 1.95
Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron (2010) 1.58
NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain. Brain Pathol (2009) 1.37
NG2 cells are distinct from neurogenic cells in the postnatal mouse subventricular zone. J Comp Neurol (2009) 1.36
Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. J Neurosci (2003) 1.12
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet (2010) 1.04
A global double-fluorescent Cre reporter mouse. Genesis (2007) 17.86
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med (2004) 11.61
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature (2005) 6.86
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Cyclin E ablation in the mouse. Cell (2003) 5.58
Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron (2009) 5.50
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Mosaic analysis with double markers in mice. Cell (2005) 5.32
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90
Mouse development and cell proliferation in the absence of D-cyclins. Cell (2004) 4.69
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation. Cell (2007) 4.55
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature (2012) 4.37
NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development (2007) 4.21
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A (2009) 4.02
Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol (2004) 3.99
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
NFKBIA deletion in glioblastomas. N Engl J Med (2010) 3.96
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron (2003) 3.78
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis. Cell (2010) 3.75
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74
PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nat Biotechnol (2011) 3.57
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med (2004) 3.55
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43
Representation of the glomerular olfactory map in the Drosophila brain. Cell (2002) 3.42
Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci (2007) 3.39
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30
Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27
Cortical representations of olfactory input by trans-synaptic tracing. Nature (2010) 3.27
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17
Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron (2006) 3.15
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med (2010) 3.09
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02
Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94
Rac function and regulation during Drosophila development. Nature (2002) 2.89
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
A network model of a cooperative genetic landscape in brain tumors. JAMA (2009) 2.86
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol (2013) 2.84
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood (2007) 2.77
Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol (2004) 2.77
New Alström syndrome phenotypes based on the evaluation of 182 cases. Arch Intern Med (2005) 2.74
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning. Dev Cell (2008) 2.56
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res (2005) 2.54
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron (2003) 2.51
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood (2007) 2.51
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A (2009) 2.46
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res (2007) 2.45
A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining. Nat Protoc (2006) 2.44
Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet (2004) 2.32
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet (2002) 2.30
Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29
Age-dependent fate and lineage restriction of single NG2 cells. Development (2011) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nat Neurosci (2010) 2.23
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A (2010) 2.20
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol (2010) 2.19
Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat Neurosci (2006) 2.19
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A (2006) 2.17
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell (2011) 2.17
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
Rac GTPases control axon growth, guidance and branching. Nature (2002) 2.14
Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 2.12
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A (2009) 2.11
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells. Nat Genet (2006) 2.10
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors. Cancer Res (2005) 2.10
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A (2002) 1.99
NG2 glial cells provide a favorable substrate for growing axons. J Neurosci (2006) 1.99