Published in N Engl J Med on September 29, 2010
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Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
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Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2010) 2.22
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2011) 1.90
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The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (2003) 1.54
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GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol (2007) 1.49
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci (2002) 1.48
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One (2007) 1.38
Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways. Proc Natl Acad Sci U S A (2006) 1.38
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci U S A (2013) 1.34
Pain as a channelopathy. J Clin Invest (2010) 1.33
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci (2010) 1.28
Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Mol Cell Neurosci (2006) 1.24
The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain. Pain Med (2011) 1.23
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Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain (2006) 1.21
Increasingly irritable and close to tears: TRPA1 in inflammatory pain. Cell (2006) 1.18
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol (2011) 1.16
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol (2012) 1.16
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci (2010) 1.15
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J (2012) 1.15
FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli. Mol Pain (2007) 1.12
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci (2006) 1.11
Kinetic properties of mechanically activated currents in spinal sensory neurons. J Physiol (2009) 1.10
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Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci (2010) 1.06
Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci (2005) 1.06
Sensory neuron voltage-gated sodium channels as analgesic drug targets. Curr Opin Neurobiol (2008) 1.06
Electrophysiological characterization of the tetrodotoxin-resistant Na+ channel, Na(v)1.9, in mouse dorsal root ganglion neurons. Pflugers Arch (2004) 1.04
RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci (2010) 1.03
No pain, more gain. Nat Genet (2013) 1.00
Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance. J Neurosci (2009) 1.00
Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11. FEBS Lett (2004) 1.00
Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves. Mol Pain (2008) 0.98
Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8. Brain Res Mol Brain Res (2003) 0.96
The mechanosensitive cell line ND-C does not express functional thermoTRP channels. Neuropharmacology (2009) 0.95
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain. Proc Natl Acad Sci U S A (2011) 0.94
Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain (2011) 0.94
Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay. Eur J Neurosci (2008) 0.92
Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain (2014) 0.92
Sodium channels and mammalian sensory mechanotransduction. Mol Pain (2012) 0.91
Transient receptor potential channels and mechanosensation. Annu Rev Neurosci (2013) 0.91
A peripheral nervous system actin-binding protein regulates neurite outgrowth. Eur J Neurosci (2002) 0.90
Mechanical allodynia. Pflugers Arch (2014) 0.90
A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. Mol Cell Neurosci (2009) 0.89
Worm sensation! Mol Pain (2005) 0.88
Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis (2006) 0.87
Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia. Neuromolecular Med (2013) 0.87
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Mol Pain (2010) 0.85
Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One (2013) 0.84
Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2). Hum Mol Genet (2013) 0.84
Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Mol Pain (2006) 0.84
Pyramidal cells of rodent presubiculum express a tetrodotoxin-insensitive Na+ current. J Physiol (2009) 0.82
G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling. Mol Med (2012) 0.82
Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction. Ann Neurol (2014) 0.82
Mechanisms of cold pain. Channels (Austin) (2007) 0.82
Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons. Brain (2010) 0.81
TRPs and pain. Handb Exp Pharmacol (2014) 0.79
Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties. PLoS One (2012) 0.79
The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain. Pain (2015) 0.77
Sodium channels and pain. Handb Exp Pharmacol (2015) 0.77
Results in analgesia--Darwin 1, pharma 0. N Engl J Med (2013) 0.76
Chapter 5 Molecular mechanisms of nociception and pain. Handb Clin Neurol (2006) 0.76
Fat location defines sensation. Proc Natl Acad Sci U S A (2009) 0.75
Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Sci Rep (2017) 0.75
From transduction to pain sensation: defining genes, cells, and circuits. Pain (2011) 0.75