PubRank

Bruce T Lahn

Author PubWeight™ 107.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Evolutionary and biomedical insights from the rhesus macaque genome. Science 2007 16.21
2 Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 2010 9.01
3 Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science 2005 5.55
4 Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science 2005 4.79
5 Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A 2010 4.63
6 Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell 2004 4.24
7 Systematic comparison of constitutive promoters and the doxycycline-inducible promoter. PLoS One 2010 2.08
8 Positive selection on the human genome. Hum Mol Genet 2004 1.95
9 Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat Genet 2004 1.71
10 Nestin is required for the proper self-renewal of neural stem cells. Stem Cells 2010 1.62
11 Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans. Hum Mol Genet 2004 1.61
12 Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proc Natl Acad Sci U S A 2006 1.54
13 Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size. Hum Mol Genet 2004 1.46
14 How mammalian sex chromosomes acquired their peculiar gene content. Bioessays 2004 1.45
15 Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem 2007 1.39
16 Genetic links between brain development and brain evolution. Nat Rev Genet 2005 1.33
17 Selective constraint on noncoding regions of hominid genomes. PLoS Comput Biol 2005 1.32
18 Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Gene 2006 1.29
19 The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Hum Mol Genet 2003 1.24
20 Genetic basis of human brain evolution. Trends Neurosci 2008 1.22
21 Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials 2012 1.20
22 Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity. Mol Biol Evol 2003 1.19
23 The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. Hum Mol Genet 2007 1.16
24 Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming. Mol Cell 2012 1.14
25 Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells. Mol Cell Biochem 2007 1.13
26 A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate. Trends Genet 2005 1.13
27 A genome-wide screen for noncoding elements important in primate evolution. BMC Evol Biol 2008 1.12
28 Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception. Genome Res 2003 1.10
29 Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet 2005 1.06
30 Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis. Nat Genet 2005 1.05
31 PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells. Int J Biochem Cell Biol 2011 0.99
32 Human polymorphism and human-chimpanzee divergence in pseudoautosomal region correlate with local recombination rate. Gene 2005 0.96
33 Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes. Mol Biol Evol 2006 0.96
34 Neural differentiation of embryonic stem cells induced by conditioned medium from neural stem cell. Neuroreport 2006 0.94
35 Localized methylation in the key regulator gene endothelin-1 is associated with cell type-specific transcriptional silencing. FEBS Lett 2006 0.92
36 Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. Hum Pathol 2010 0.92
37 A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway. Hum Mol Genet 2006 0.90
38 Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res 2012 0.88
39 Diverse fates of paralogs following segmental duplication of telomeric genes. Genomics 2004 0.88
40 Systematic identification of cis-silenced genes by trans complementation. Hum Mol Genet 2008 0.88
41 Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells. Differentiation 2008 0.87
42 SPEED: a molecular-evolution-based database of mammalian orthologous groups. Bioinformatics 2006 0.87
43 Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells. Biomaterials 2012 0.87
44 A genetic legacy from archaic Homo. Trends Genet 2007 0.87
45 Evidence for a critical role of gene occlusion in cell fate restriction. Cell Res 2011 0.85
46 Generation of functional hepatocytes from mouse induced pluripotent stem cells. J Cell Physiol 2010 0.85
47 Chromatin analysis of occluded genes. Hum Mol Genet 2009 0.84
48 Uncovering the mutation-fixation correlation in short lineages. BMC Evol Biol 2007 0.84
49 Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Hum Mol Genet 2006 0.83
50 The radial glia antibody RC2 recognizes a protein encoded by Nestin. Biochem Biophys Res Commun 2009 0.83
51 Effects of chromosomal rearrangements on human-chimpanzee molecular evolution. Genomics 2004 0.82
52 The evolution of word composition in metazoan promoter sequence. PLoS Comput Biol 2006 0.81
53 The X chromosome: not just her brother's keeper. Nat Genet 2005 0.81
54 A stem cell-based tool for small molecule screening in adipogenesis. PLoS One 2010 0.80
55 Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host. Hum Mol Genet 2007 0.80
56 Slower cycling of nestin-positive cells in neurosphere culture. Neuroreport 2006 0.79
57 Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells. Genome Res 2013 0.79
58 Hereditary hyperekplexia caused by novel mutations of GLRA1 in Turkish families. Mol Diagn 2004 0.79
59 Improved DNA methylation analysis via enrichment of demethylated cells expressing an X-inactivated transgene. Biotechniques 2006 0.78
60 Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test. Toxicol Mech Methods 2010 0.78
61 Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells. Cell Biol Int 2008 0.77
62 Different classes of tissue-specific genes show different levels of noncoding conservation. Genomics 2005 0.77
63 What makes us human: revisiting an age-old question in the genomic era. J Biomed Discov Collab 2006 0.77
64 Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro. BMC Cell Biol 2010 0.77
65 Mathematical models for the proliferation of neural stem/progenitor cells in clonogenic culture. Rejuvenation Res 2007 0.76
66 Involvement of extracellular factors in maintaining self-renewal of neural stem cell by nestin. Neuroreport 2014 0.76
67 Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors. Cell Transplant 2010 0.76
68 Establishment and characterization of two new human embryonic stem cell lines, SYSU-1 and SYSU-2. Chin Med J (Engl) 2007 0.75
69 Multiple independent origins of sex chromosomes in amniotes. Proc Natl Acad Sci U S A 2006 0.75
70 Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey. Neuroreport 2008 0.75