Published in Science on September 09, 2005
A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
Primary microcephaly: do all roads lead to Rome? Trends Genet (2009) 3.60
How culture shaped the human genome: bringing genetics and the human sciences together. Nat Rev Genet (2010) 3.21
Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01
Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet (2006) 3.00
Neanderthal brain size at birth provides insights into the evolution of human life history. Proc Natl Acad Sci U S A (2008) 2.02
Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin. Proc Natl Acad Sci U S A (2007) 1.95
A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations. Proc Natl Acad Sci U S A (2009) 1.84
Genome-wide scans for footprints of natural selection. Philos Trans R Soc Lond B Biol Sci (2010) 1.84
A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet (2011) 1.80
Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum. Orphanet J Rare Dis (2011) 1.78
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A (2010) 1.76
Explaining human uniqueness: genome interactions with environment, behaviour and culture. Nat Rev Genet (2008) 1.67
Two evolutionary histories in the genome of rice: the roles of domestication genes. PLoS Genet (2011) 1.63
Sex-dependent association of common variants of microcephaly genes with brain structure. Proc Natl Acad Sci U S A (2009) 1.55
Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet (2013) 1.47
Ethics: Taboo genetics. Nature (2013) 1.42
Accelerated recruitment of new brain development genes into the human genome. PLoS Biol (2011) 1.39
On the antiquity of language: the reinterpretation of Neandertal linguistic capacities and its consequences. Front Psychol (2013) 1.38
Genome-wide DNA polymorphism analyses using VariScan. BMC Bioinformatics (2006) 1.31
Distinguishing between selective sweeps from standing variation and from a de novo mutation. PLoS Genet (2012) 1.31
Evolution and the Growth Process: Natural Selection of Entrepreneurial Traits. J Econ Theory (2012) 1.31
Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: Novel sequence variants in ASPM gene. Neurogenetics (2006) 1.26
Spindle orientation in mammalian cerebral cortical development. Curr Opin Neurobiol (2012) 1.17
Allelic diversity in human developmental neurogenetics: insights into biology and disease. Neuron (2010) 1.17
Genes, cognition, and communication: insights from neurodevelopmental disorders. Ann N Y Acad Sci (2009) 1.16
Molecular evolution of genes in avian genomes. Genome Biol (2010) 1.12
SNP@Evolution: a hierarchical database of positive selection on the human genome. BMC Evol Biol (2009) 1.11
Whole brain size and general mental ability: a review. Int J Neurosci (2009) 1.07
Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history. Mol Biol Evol (2009) 1.07
Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens". Science (2007) 1.06
Patterns of molecular evolution associated with two selective sweeps in the Tb1-Dwarf8 region in maize. Genetics (2008) 1.05
The human brain: rewired and running hot. Ann N Y Acad Sci (2011) 1.04
Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum. Genetics (2007) 1.03
Human genomic disease variants: a neutral evolutionary explanation. Genome Res (2012) 1.02
Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior. Neuron (2010) 0.99
The dynamic role of genetics on cortical patterning during childhood and adolescence. Proc Natl Acad Sci U S A (2014) 0.96
Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J Biol Chem (2008) 0.95
Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM. Science (2007) 0.94
The developmental brain gene NPAS3 contains the largest number of accelerated regulatory sequences in the human genome. Mol Biol Evol (2013) 0.93
No evidence that polymorphisms of brain regulator genes Microcephalin and ASPM are associated with general mental ability, head circumference or altruism. Biol Lett (2007) 0.92
Detecting natural selection by empirical comparison to random regions of the genome. Hum Mol Genet (2009) 0.92
A twin study of intracerebral volumetric relationships. Behav Genet (2010) 0.92
Perspective on the human cough reflex. Cough (2011) 0.91
Molecular clock: an anti-neo-Darwinian legacy. Genetics (2007) 0.90
Identifying dramatic selection shifts in phylogenetic trees. BMC Evol Biol (2007) 0.90
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas. BMC Genet (2007) 0.90
Prospects for delaying the rising tide of worldwide, late-life dementias. Int Psychogeriatr (2010) 0.90
The derived allele of ASPM is associated with lexical tone perception. PLoS One (2012) 0.89
Human evolutionary genomics: ethical and interpretive issues. Trends Genet (2012) 0.89
Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. J Med Genet (2007) 0.88
Role of BRCA1 in brain development. Proc Natl Acad Sci U S A (2014) 0.87
Being positive about selection. PLoS Biol (2006) 0.87
Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage. Biol Direct (2006) 0.87
Reciprocal anatomical relationship between primary sensory and prefrontal cortices in the human brain. J Neurosci (2011) 0.86
Evolution. Are human brains still evolving? Brain genes show signs of selection. Science (2005) 0.85
Exploring the origins of the human brain through molecular evolution. Brain Behav Evol (2008) 0.85
A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice. Philos Trans R Soc Lond B Biol Sci (2013) 0.84
Evolutionary forces shaping genomic islands of population differentiation in humans. BMC Genomics (2012) 0.82
Human difference in the genomic era: Facilitating a socially responsible dialogue. BMC Med Genomics (2010) 0.82
A potential role for glucose transporters in the evolution of human brain size. Brain Behav Evol (2011) 0.81
Cerebral cortex expansion and folding: what have we learned? EMBO J (2016) 0.81
Ethical, legal, social, and policy implications of behavioral genetics. Annu Rev Genomics Hum Genet (2013) 0.81
SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions. J Mol Evol (2006) 0.81
Evidence for positive selection on the Osteogenin (BMP3) gene in human populations. PLoS One (2010) 0.80
Microcephaly genes evolved adaptively throughout the evolution of eutherian mammals. BMC Evol Biol (2014) 0.78
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. Curr Gerontol Geriatr Res (2012) 0.78
Evolutionary genomics of human intellectual disability. Evol Appl (2009) 0.78
Expression change in Angiopoietin-1 underlies change in relative brain size in fish. Proc Biol Sci (2015) 0.77
Why are there so many explanations for primate brain evolution? Philos Trans R Soc Lond B Biol Sci (2017) 0.77
Male and female brain evolution is subject to contrasting selection pressures in primates. BMC Biol (2007) 0.76
Genetic correlates of the evolving primate brain. Prog Brain Res (2012) 0.76
Worldwide population distribution of the common LCE3C-LCE3B deletion associated with psoriasis and other autoimmune disorders. BMC Genomics (2013) 0.75
Darwin 200: The other strand. Nature (2009) 0.75
Microcephaly genes and risk of late-onset Alzheimer disease. Alzheimer Dis Assoc Disord (2011) 0.75
ASPM and the evolution of cerebral cortical size in a community of New World monkeys. PLoS One (2012) 0.75
Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations. Hum Genet (2016) 0.75
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci U S A (2005) 5.21
Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science (2005) 4.79
Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A (2010) 4.63
Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell (2004) 4.24
Maximum-likelihood estimation of demographic parameters using the frequency spectrum of unlinked single-nucleotide polymorphisms. Genetics (2004) 4.02
Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Hum Genomics (2005) 3.77
Great ape genetic diversity and population history. Nature (2013) 2.95
Inferences about human demography based on multilocus analyses of noncoding sequences. Genetics (2002) 2.95
An evolutionary framework for common diseases: the ancestral-susceptibility model. Trends Genet (2005) 2.92
Whole-mtDNA genome sequence analysis of ancient African lineages. Mol Biol Evol (2006) 2.82
African human diversity, origins and migrations. Curr Opin Genet Dev (2006) 2.68
Adaptive genic evolution in the Drosophila genomes. Proc Natl Acad Sci U S A (2007) 2.56
Systematic comparison of constitutive promoters and the doxycycline-inducible promoter. PLoS One (2010) 2.08
Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers. Cell (2012) 2.00
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
Positive selection on the human genome. Hum Mol Genet (2004) 1.95
Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates. Am J Hum Genet (2003) 1.89
The genetic prehistory of southern Africa. Nat Commun (2012) 1.78
Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet (2008) 1.73
Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat Genet (2004) 1.71
Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms. Gene (2006) 1.68
The evolution of human genetic and phenotypic variation in Africa. Curr Biol (2010) 1.65
Two evolutionary histories in the genome of rice: the roles of domestication genes. PLoS Genet (2011) 1.63
Nestin is required for the proper self-renewal of neural stem cells. Stem Cells (2010) 1.62
Structural diversity and African origin of the 17q21.31 inversion polymorphism. Nat Genet (2012) 1.62
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am J Hum Genet (2002) 1.61
Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans. Hum Mol Genet (2004) 1.61
Evidence for balancing selection from nucleotide sequence analyses of human G6PD. Am J Hum Genet (2002) 1.58
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther (2007) 1.57
Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Hum Genet (2008) 1.57
Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proc Natl Acad Sci U S A (2006) 1.54
Genetic adaptation to high altitude in the Ethiopian highlands. Genome Biol (2012) 1.48
Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa. Proc Natl Acad Sci U S A (2008) 1.46
Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size. Hum Mol Genet (2004) 1.46
How mammalian sex chromosomes acquired their peculiar gene content. Bioessays (2004) 1.45
Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem (2007) 1.39
Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Am J Hum Genet (2013) 1.35
Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies. PLoS Genet (2012) 1.33
Genetic links between brain development and brain evolution. Nat Rev Genet (2005) 1.33
Selective constraint on noncoding regions of hominid genomes. PLoS Comput Biol (2005) 1.32
Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology (2010) 1.31
Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations. Proc Natl Acad Sci U S A (2011) 1.31
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Gene (2006) 1.29
Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history. Proc Natl Acad Sci U S A (2010) 1.27
The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Hum Mol Genet (2003) 1.24
Genetic basis of human brain evolution. Trends Neurosci (2008) 1.22
Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials (2012) 1.20
Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity. Mol Biol Evol (2003) 1.19
SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it. Bioessays (2013) 1.18
The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. Hum Mol Genet (2007) 1.16
Positive selection can create false hotspots of recombination. Genetics (2005) 1.15
Living the high life: high-altitude adaptation. Genome Biol (2010) 1.15
Recent human adaptation: genomic approaches, interpretation and insights. Nat Rev Genet (2013) 1.15
Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study. J Gerontol A Biol Sci Med Sci (2013) 1.15
Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming. Mol Cell (2012) 1.14
Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers. BMC Med Genomics (2014) 1.13
Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells. Mol Cell Biochem (2007) 1.13
A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate. Trends Genet (2005) 1.13
A genome-wide screen for noncoding elements important in primate evolution. BMC Evol Biol (2008) 1.12
Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception. Genome Res (2003) 1.10
Haplotype variation and genotype imputation in African populations. Genet Epidemiol (2011) 1.10
Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans. Carcinogenesis (2009) 1.08
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet (2007) 1.08
A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med (2012) 1.08
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci U S A (2012) 1.06
Signatures of selection and gene conversion associated with human color vision variation. Am J Hum Genet (2004) 1.06
Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet (2005) 1.06
Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis. Nat Genet (2005) 1.05
Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol Biol Evol (2011) 1.05
A reduced representation approach to population genetic analyses and applications to human evolution. Genome Res (2011) 1.05
Trace amine associated receptor 1 signaling in activated lymphocytes. J Neuroimmune Pharmacol (2011) 1.05