Published in Science on September 09, 2005
A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
Why did modern human populations disperse from Africa ca. 60,000 years ago? A new model. Proc Natl Acad Sci U S A (2006) 4.22
Primary microcephaly: do all roads lead to Rome? Trends Genet (2009) 3.60
How culture shaped the human genome: bringing genetics and the human sciences together. Nat Rev Genet (2010) 3.21
Gene losses during human origins. PLoS Biol (2006) 3.17
Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A (2007) 2.81
Molecular spandrels: tests of adaptation at the genetic level. Nat Rev Genet (2011) 2.07
Neanderthal brain size at birth provides insights into the evolution of human life history. Proc Natl Acad Sci U S A (2008) 2.02
Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin. Proc Natl Acad Sci U S A (2007) 1.95
A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations. Proc Natl Acad Sci U S A (2009) 1.84
A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet (2011) 1.80
Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum. Orphanet J Rare Dis (2011) 1.78
MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol (2011) 1.69
Explaining human uniqueness: genome interactions with environment, behaviour and culture. Nat Rev Genet (2008) 1.67
Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA. PLoS One (2011) 1.60
Adaptive evolution of genes underlying schizophrenia. Proc Biol Sci (2007) 1.58
Sex-dependent association of common variants of microcephaly genes with brain structure. Proc Natl Acad Sci U S A (2009) 1.55
Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proc Natl Acad Sci U S A (2006) 1.54
Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet (2013) 1.47
Ethics: Taboo genetics. Nature (2013) 1.42
Brain shape in human microcephalics and Homo floresiensis. Proc Natl Acad Sci U S A (2007) 1.41
Accelerated recruitment of new brain development genes into the human genome. PLoS Biol (2011) 1.39
Identifying gene regulatory networks in schizophrenia. Neuroimage (2010) 1.34
Genes, cognition, and communication: insights from neurodevelopmental disorders. Ann N Y Acad Sci (2009) 1.16
Molecular evolution of genes in avian genomes. Genome Biol (2010) 1.12
A genome-wide screen for noncoding elements important in primate evolution. BMC Evol Biol (2008) 1.12
Genomic sister-disorders of neurodevelopment: an evolutionary approach. Evol Appl (2009) 1.09
A hierarchical model of the evolution of human brain specializations. Proc Natl Acad Sci U S A (2012) 1.08
Whole brain size and general mental ability: a review. Int J Neurosci (2009) 1.07
Patterns of molecular evolution associated with two selective sweeps in the Tb1-Dwarf8 region in maize. Genetics (2008) 1.05
The human brain: rewired and running hot. Ann N Y Acad Sci (2011) 1.04
Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum. Genetics (2007) 1.03
Human genomic disease variants: a neutral evolutionary explanation. Genome Res (2012) 1.02
Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework. Schizophr Bull (2007) 1.01
Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior. Neuron (2010) 0.99
Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Am J Hum Genet (2009) 0.98
Review. Genetic exchange and the origin of adaptations: prokaryotes to primates. Philos Trans R Soc Lond B Biol Sci (2008) 0.97
The dynamic role of genetics on cortical patterning during childhood and adolescence. Proc Natl Acad Sci U S A (2014) 0.96
A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. Genes Immun (2010) 0.95
Positive selection within the Schizophrenia-associated GABA(A) receptor beta(2) gene. PLoS One (2007) 0.95
Mapping behavioural evolution onto brain evolution: the strategic roles of conserved organization in individuals and species. Philos Trans R Soc Lond B Biol Sci (2011) 0.94
Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM. Science (2007) 0.94
Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene. Hum Genet (2010) 0.93
The developmental brain gene NPAS3 contains the largest number of accelerated regulatory sequences in the human genome. Mol Biol Evol (2013) 0.93
No evidence that polymorphisms of brain regulator genes Microcephalin and ASPM are associated with general mental ability, head circumference or altruism. Biol Lett (2007) 0.92
Detecting natural selection by empirical comparison to random regions of the genome. Hum Mol Genet (2009) 0.92
A twin study of intracerebral volumetric relationships. Behav Genet (2010) 0.92
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas. BMC Genet (2007) 0.90
Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes. Brain Behav Evol (2013) 0.90
Clinical implications of human population differences in genome-wide rates of functional genotypes. Front Genet (2012) 0.90
Prospects for delaying the rising tide of worldwide, late-life dementias. Int Psychogeriatr (2010) 0.90
Human evolutionary genomics: ethical and interpretive issues. Trends Genet (2012) 0.89
The derived allele of ASPM is associated with lexical tone perception. PLoS One (2012) 0.89
Paleopopulation genetics. Annu Rev Genet (2012) 0.88
Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. J Med Genet (2007) 0.88
Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage. Biol Direct (2006) 0.87
Role of BRCA1 in brain development. Proc Natl Acad Sci U S A (2014) 0.87
Being positive about selection. PLoS Biol (2006) 0.87
Reciprocal anatomical relationship between primary sensory and prefrontal cortices in the human brain. J Neurosci (2011) 0.86
The microcephalin ancestral allele in a Neanderthal individual. PLoS One (2010) 0.85
Exploring the origins of the human brain through molecular evolution. Brain Behav Evol (2008) 0.85
Evolution. Are human brains still evolving? Brain genes show signs of selection. Science (2005) 0.85
Polymorphism due to multiple amino acid substitutions at a codon site within Ciona savignyi. Genetics (2008) 0.84
A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice. Philos Trans R Soc Lond B Biol Sci (2013) 0.84
Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors. Genome Biol Evol (2014) 0.82
An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection. PLoS Genet (2014) 0.82
Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. PLoS One (2012) 0.82
Human difference in the genomic era: Facilitating a socially responsible dialogue. BMC Med Genomics (2010) 0.82
Ethical, legal, social, and policy implications of behavioral genetics. Annu Rev Genomics Hum Genet (2013) 0.81
SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions. J Mol Evol (2006) 0.81
Cerebral cortex expansion and folding: what have we learned? EMBO J (2016) 0.81
A potential role for glucose transporters in the evolution of human brain size. Brain Behav Evol (2011) 0.81
Evidence for positive selection on the Osteogenin (BMP3) gene in human populations. PLoS One (2010) 0.80
Microcephaly genes evolved adaptively throughout the evolution of eutherian mammals. BMC Evol Biol (2014) 0.78
MCPH1: a window into brain development and evolution. Front Cell Neurosci (2015) 0.78
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. Curr Gerontol Geriatr Res (2012) 0.78
Evolutionary genomics of human intellectual disability. Evol Appl (2009) 0.78
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res (2016) 0.78
Expression change in Angiopoietin-1 underlies change in relative brain size in fish. Proc Biol Sci (2015) 0.77
A complex selection signature at the human AVPR1B gene. BMC Evol Biol (2009) 0.77
Why are there so many explanations for primate brain evolution? Philos Trans R Soc Lond B Biol Sci (2017) 0.77
Genetic correlates of the evolving primate brain. Prog Brain Res (2012) 0.76
Male and female brain evolution is subject to contrasting selection pressures in primates. BMC Biol (2007) 0.76
Darwin 200: The other strand. Nature (2009) 0.75
How smart is smart? Is human intelligence still evolving? EMBO Rep (2009) 0.75
Population genetics of mouse lemur vomeronasal receptors: current versus past selection and demographic inference. BMC Evol Biol (2017) 0.75
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science (2005) 5.55
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci U S A (2005) 5.21
Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A (2010) 4.63
Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell (2004) 4.24
Maximum-likelihood estimation of demographic parameters using the frequency spectrum of unlinked single-nucleotide polymorphisms. Genetics (2004) 4.02
Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Hum Genomics (2005) 3.77
Inferences about human demography based on multilocus analyses of noncoding sequences. Genetics (2002) 2.95
Great ape genetic diversity and population history. Nature (2013) 2.95
An evolutionary framework for common diseases: the ancestral-susceptibility model. Trends Genet (2005) 2.92
Whole-mtDNA genome sequence analysis of ancient African lineages. Mol Biol Evol (2006) 2.82
African human diversity, origins and migrations. Curr Opin Genet Dev (2006) 2.68
Adaptive genic evolution in the Drosophila genomes. Proc Natl Acad Sci U S A (2007) 2.56
Systematic comparison of constitutive promoters and the doxycycline-inducible promoter. PLoS One (2010) 2.08
Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers. Cell (2012) 2.00
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
Positive selection on the human genome. Hum Mol Genet (2004) 1.95
Intellectual developmental disorders: towards a new name, definition and framework for "mental retardation/intellectual disability" in ICD-11. World Psychiatry (2011) 1.94
Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates. Am J Hum Genet (2003) 1.89
The genetic prehistory of southern Africa. Nat Commun (2012) 1.78
Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet (2008) 1.73
Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat Genet (2004) 1.71
Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms. Gene (2006) 1.68
The evolution of human genetic and phenotypic variation in Africa. Curr Biol (2010) 1.65
Two evolutionary histories in the genome of rice: the roles of domestication genes. PLoS Genet (2011) 1.63
Nestin is required for the proper self-renewal of neural stem cells. Stem Cells (2010) 1.62
Structural diversity and African origin of the 17q21.31 inversion polymorphism. Nat Genet (2012) 1.62
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am J Hum Genet (2002) 1.61
Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans. Hum Mol Genet (2004) 1.61
Evidence for balancing selection from nucleotide sequence analyses of human G6PD. Am J Hum Genet (2002) 1.58
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther (2007) 1.57
Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Hum Genet (2008) 1.57
Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proc Natl Acad Sci U S A (2006) 1.54
Genetic adaptation to high altitude in the Ethiopian highlands. Genome Biol (2012) 1.48
Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa. Proc Natl Acad Sci U S A (2008) 1.46
Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size. Hum Mol Genet (2004) 1.46
How mammalian sex chromosomes acquired their peculiar gene content. Bioessays (2004) 1.45
Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem (2007) 1.39
Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Am J Hum Genet (2013) 1.35
Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies. PLoS Genet (2012) 1.33
Genetic links between brain development and brain evolution. Nat Rev Genet (2005) 1.33
Selective constraint on noncoding regions of hominid genomes. PLoS Comput Biol (2005) 1.32
Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology (2010) 1.31
Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations. Proc Natl Acad Sci U S A (2011) 1.31
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Gene (2006) 1.29
Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history. Proc Natl Acad Sci U S A (2010) 1.27
The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Hum Mol Genet (2003) 1.24
Genetic basis of human brain evolution. Trends Neurosci (2008) 1.22
Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials (2012) 1.20
Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity. Mol Biol Evol (2003) 1.19
SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it. Bioessays (2013) 1.18
The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. Hum Mol Genet (2007) 1.16
Living the high life: high-altitude adaptation. Genome Biol (2010) 1.15
Positive selection can create false hotspots of recombination. Genetics (2005) 1.15
Recent human adaptation: genomic approaches, interpretation and insights. Nat Rev Genet (2013) 1.15
Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study. J Gerontol A Biol Sci Med Sci (2013) 1.15
Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming. Mol Cell (2012) 1.14
Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers. BMC Med Genomics (2014) 1.13
Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells. Mol Cell Biochem (2007) 1.13
A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate. Trends Genet (2005) 1.13
A genome-wide screen for noncoding elements important in primate evolution. BMC Evol Biol (2008) 1.12
Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception. Genome Res (2003) 1.10
Haplotype variation and genotype imputation in African populations. Genet Epidemiol (2011) 1.10
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet (2007) 1.08
Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans. Carcinogenesis (2009) 1.08
A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med (2012) 1.08
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci U S A (2012) 1.06
Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet (2005) 1.06
Signatures of selection and gene conversion associated with human color vision variation. Am J Hum Genet (2004) 1.06