A mouse for all reasons.

A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93

The Mouse Genome Database (MGD): mouse biology and model systems. Nucleic Acids Res (2007) 9.75

A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78

Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res (2009) 4.62

The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res (2010) 4.58

Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium. Nucleic Acids Res (2010) 3.23

The mammalian phenotype ontology: enabling robust annotation and comparative analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 3.00

EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res (2009) 2.72

The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A (2013) 2.63

EuroPhenome and EMPReSS: online mouse phenotyping resource. Nucleic Acids Res (2007) 2.54

The Mouse Genome Database: enhancements and updates. Nucleic Acids Res (2009) 2.44

The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data. Mamm Genome (2012) 2.43

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32

A new partner for the international knockout mouse consortium. Cell (2007) 2.23

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12

The mouse Gene Expression Database (GXD): 2011 update. Nucleic Acids Res (2010) 2.07

Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods (2010) 2.05

Extensive genomic copy number variation in embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.91

EMMA--mouse mutant resources for the international scientific community. Nucleic Acids Res (2009) 1.75

Reduced body weight is a common effect of gene knockout in mice. BMC Genet (2008) 1.72

Genomic copy number and expression variation within the C57BL/6J inbred mouse strain. Genome Res (2007) 1.71

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data. BMC Bioinformatics (2009) 1.70

Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation. PLoS One (2008) 1.70

A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66

Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies. J Neurogenet (2008) 1.66

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet (2012) 1.64

Pathbase and the MPATH ontology. Community resources for mouse histopathology. Vet Pathol (2010) 1.64

Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans. Mamm Genome (2012) 1.63

Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training. Mamm Genome (2008) 1.62

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling. Nat Rev Genet (2009) 1.59

Pathway projector: web-based zoomable pathway browser using KEGG atlas and Google Maps API. PLoS One (2009) 1.57

Genetic background determines metabolic phenotypes in the mouse. Mamm Genome (2008) 1.51

Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat Neurosci (2008) 1.43

Robust and sensitive analysis of mouse knockout phenotypes. PLoS One (2012) 1.35

Mouse embryonic phenotyping by morphometric analysis of MR images. Physiol Genomics (2010) 1.29

Phenotype ontologies for mouse and man: bridging the semantic gap. Dis Model Mech (2010) 1.28

Phenotypic annotation of the mouse X chromosome. Genome Res (2010) 1.26

Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat Rev Drug Discov (2009) 1.22

Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update (2009) 1.22

A knockout mouse resource for the biomedical research community. Ann N Y Acad Sci (2011) 1.21

PRIME importance of pathology expertise. Nat Biotechnol (2009) 1.19

Cautionary insights on knockout mouse studies: the gene or not the gene? Brain Behav Immun (2008) 1.14

Linking genes to diseases: it's all in the data. Genome Med (2009) 1.14

Sorting and expansion of murine embryonic stem cell colonies using micropallet arrays. Cytometry A (2009) 1.13

Mouse genome database 2016. Nucleic Acids Res (2015) 1.11

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. Nat Methods (2011) 1.11

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos. PLoS One (2012) 1.10

PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res (2007) 1.07

The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05

Searching for genes underlying behavior: lessons from circadian rhythms. Science (2008) 1.04

Caution! Analyze transcripts from conditional knockout alleles. Transgenic Res (2008) 1.04

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry (2014) 1.04

Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT. Development (2014) 1.03

Interaction of enteric bacterial pathogens with murine embryonic stem cells. Infect Immun (2008) 1.03

Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports (2013) 1.02

Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse. Genetics (2011) 1.02

Structural stabilization of tissue for embryo phenotyping using micro-CT with iodine staining. PLoS One (2013) 1.01

Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease. Am J Physiol Gastrointest Liver Physiol (2010) 0.99

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98

The UniTrap resource: tools for the biologist enabling optimized use of gene trap clones. Nucleic Acids Res (2007) 0.98

Optimising experimental design for high-throughput phenotyping in mice: a case study. Mamm Genome (2010) 0.98

MASTR: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice. Cell Rep (2012) 0.97

Mouse genetics: catalogue and scissors. BMB Rep (2012) 0.97

Linking RNA biology to lncRNAs. Genome Res (2015) 0.97

Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97

Reverse genetics in eukaryotes. Biol Cell (2010) 0.97

Legal agreements and the governance of research commons: lessons from materials sharing in mouse genomics. OMICS (2014) 0.96

BioMart as an integration solution for the International Knockout Mouse Consortium. Database (Oxford) (2011) 0.96

Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome (2013) 0.96

A mitotic recombination system for mouse chromosome 17. Proc Natl Acad Sci U S A (2008) 0.93

Efficient detection, quantification and enrichment of subtle allelic alterations. DNA Res (2012) 0.93

Genes and biological processes commonly disrupted in rare and heterogeneous developmental delay syndromes. Hum Mol Genet (2010) 0.93

Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice. Circ Cardiovasc Imaging (2013) 0.92

Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A (2015) 0.91

After GWAS: mice to the rescue? Curr Opin Immunol (2012) 0.91

The construction of transgenic and gene knockout/knockin mouse models of human disease. Transgenic Res (2011) 0.91

Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data. Bioinformatics (2012) 0.91

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron (2016) 0.90

Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes. BMC Biotechnol (2015) 0.90

Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs. Nucleic Acids Res (2008) 0.90

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes (2016) 0.90

Enhanced gene trapping in mouse embryonic stem cells. Nucleic Acids Res (2008) 0.89

A race through the maze of genomic evidence. Genome Biol (2008) 0.89

Cardiac-specific inducible and conditional gene targeting in mice. Circ Res (2012) 0.88

Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem (2012) 0.88

The scientific quest for lasting youth: prospects for curing aging. Rejuvenation Res (2014) 0.87

High-resolution MRI of early-stage mouse embryos. NMR Biomed (2012) 0.87

Fcγ receptor-mediated inflammation inhibits axon regeneration. PLoS One (2014) 0.87

A high-speed congenic strategy using first-wave male germ cells. PLoS One (2009) 0.87

Cardiovascular magnetic resonance imaging in experimental models. Open Cardiovasc Med J (2010) 0.87

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies. PLoS One (2014) 0.86

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PLoS One (2014) 0.85

High-throughput, high-frequency 3-D ultrasound for in utero analysis of embryonic mouse brain development. Ultrasound Med Biol (2013) 0.84

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep (2015) 0.84

Mouse Resource Browser--a database of mouse databases. Database (Oxford) (2010) 0.83

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Cell Rep (2016) 0.83

Bi-allelic gene targeting in mouse embryonic stem cells. Methods (2011) 0.83

Utilising the resources of the International Knockout Mouse Consortium: the Australian experience. Mamm Genome (2015) 0.83

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48

International network of cancer genome projects. Nature (2010) 20.35

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Replicating genotype-phenotype associations. Nature (2007) 16.11

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

Policy: NIH plans to enhance reproducibility. Nature (2014) 15.71

New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

The path to personalized medicine. N Engl J Med (2010) 9.87

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18

Policy: NIH to balance sex in cell and animal studies. Nature (2014) 9.15

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09

Ethics. Identifiability in genomic research. Science (2007) 9.08

The family history--more important than ever. N Engl J Med (2004) 8.35

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

The knockout mouse project. Nat Genet (2004) 7.80

Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2004) 7.55

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell (2005) 7.30

NIH Molecular Libraries Initiative. Science (2004) 7.04

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Methods (2006) 6.25

Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. Genome Res (2010) 5.76

Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72

Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71

Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med (2008) 5.34

MicroRNA target site polymorphisms and human disease. Trends Genet (2008) 5.32

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19

Endothelial cells and VEGF in vascular development. Nature (2005) 4.92

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 4.80

Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77

Genomic medicine--a primer. N Engl J Med (2002) 4.77

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Genes, environment and the value of prospective cohort studies. Nat Rev Genet (2006) 4.33

Retinoid signaling determines germ cell fate in mice. Science (2006) 4.17

Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97

A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A (2010) 3.90

Human laminopathies: nuclei gone genetically awry. Nat Rev Genet (2006) 3.89

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86

New models for large prospective studies: is there a better way? Am J Epidemiol (2012) 3.85

The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84

NIH basics. Science (2012) 3.82

Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. Cancer Res (2002) 3.68

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 3.64

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med (2007) 3.61

Research priorities. The NIH BRAIN Initiative. Science (2013) 3.61

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51

Genomic medicine--an updated primer. N Engl J Med (2010) 3.48

Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A (2004) 3.41

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

The genome gets personal--almost. JAMA (2008) 3.28

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25

Keeping pace with the times--the Genetic Information Nondiscrimination Act of 2008. N Engl J Med (2008) 3.22

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development (2003) 3.14

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A (2003) 3.05

Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. Nat Genet (2002) 2.94

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A (2013) 2.93

Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92