Published in Cell Res on March 29, 2011
Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biol (2013) 1.34
Reactive oxygen species in skeletal muscle signaling. J Signal Transduct (2011) 1.23
Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise. J Biol Chem (2014) 1.12
Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. BMC Med (2013) 1.01
Automated gas-phase purification for accurate, multiplexed quantification on a stand-alone ion-trap mass spectrometer. Anal Chem (2012) 0.85
The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes. J Muscle Res Cell Motil (2016) 0.85
dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle (2012) 0.83
Cardiac stem cells: biology and clinical applications. Antioxid Redox Signal (2014) 0.80
High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria. Biomolecules (2015) 0.80
Endogenous hydrogen peroxide production in the epithelium of the developing embryonic lens. Mol Vis (2014) 0.80
Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart. Am J Cardiovasc Dis (2016) 0.79
Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells. Oncotarget (2015) 0.79
'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'. Cell Death Dis (2016) 0.79
The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. Neurobiol Dis (2015) 0.78
Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress. FASEB J (2012) 0.78
Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation. Cell Commun Signal (2014) 0.77
Resistance training to improve type 2 diabetes: working toward a prescription for the future. Nutr Metab (Lond) (2017) 0.76
Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy. Sci Rep (2017) 0.75
Different Endosymbiotic Interactions in Two Hydra Species Reflect the Evolutionary History of Endosymbiosis. Genome Biol Evol (2016) 0.75
Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease. Front Physiol (2017) 0.75
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Sci Rep (2017) 0.75
The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence. J Biol Chem (2017) 0.75
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
How mitochondria produce reactive oxygen species. Biochem J (2009) 13.03
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med (2002) 4.70
The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem (2009) 3.86
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Bovine complex I is a complex of 45 different subunits. J Biol Chem (2006) 3.01
Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am J Physiol Cell Physiol (2004) 2.40
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am J Physiol Heart Circ Physiol (2007) 2.24
Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol (2005) 2.00
Mitochondrial DNA replication during differentiation of murine embryonic stem cells. J Cell Sci (2007) 1.98
The pathophysiology of mitochondrial disease as modeled in the mouse. Genes Dev (2009) 1.87
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res (2009) 1.70
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69
Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J Biol Chem (2005) 1.60
Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits. J Biol Chem (2007) 1.56
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes Dev (2007) 1.53
Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J (2008) 1.53
Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase. J Cell Sci (2007) 1.46
The effects of superoxide dismutase on H2O2 formation. Free Radic Biol Med (2007) 1.45
Differentiation of beating cardiac muscle cells from a derivative of P19 embryonal carcinoma cells. Cell Struct Funct (1996) 1.41
Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem (2009) 1.41
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res (2007) 1.33
Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake. Diabetes (2007) 1.29
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med (2008) 1.24
Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. J Biol Chem (1994) 1.22
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities. J Cell Physiol (2001) 1.21
Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death. Cell Death Differ (2006) 1.21
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci (2008) 1.17
Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death. Cancer Res (2007) 1.16
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem (2007) 1.16
Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol (2007) 1.14
The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. Free Radic Biol Med (2009) 1.09
Nox 2 stimulates muscle differentiation via NF-kappaB/iNOS pathway. Free Radic Biol Med (2005) 1.07
Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci (2009) 1.05
Mitochondrial DNA damage in iron overload. J Biol Chem (2008) 1.04
Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions. Free Radic Biol Med (2008) 1.00
Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 0.96
The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. J Biol Chem (2009) 0.95
CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol Cell Biol (2008) 0.94
Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK/JNK, and cPLA2 signaling pathways. Am J Physiol Cell Physiol (2004) 0.92
Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation. Am J Pathol (2008) 0.92
RhoA/Rho kinase blocks muscle differentiation via serine phosphorylation of insulin receptor substrate-1 and -2. Mol Endocrinol (2007) 0.91
Differential production of superoxide by neuronal mitochondria. BMC Neurosci (2008) 0.89
Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. Cell Res (2010) 0.84
Thermodynamics of reverse electron transfer across site 1: ATP/2e- is greater than one. Biochem Biophys Res Commun (1984) 0.83
Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-kappaB are required for C2C12-RasV12C40 myoblast differentiation. Endocrinology (2007) 0.78
A new structural alternative in benzo[b]furans for antimicrobial activity. Bioorg Med Chem (2005) 16.13
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem (2007) 3.31
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 2.98
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med (2004) 2.80
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes (2007) 2.34
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23
Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol (2008) 2.18
Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A (2003) 2.12
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 1.96
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp (2004) 1.82
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol (2005) 1.82
Glutathionylation of mitochondrial proteins. Antioxid Redox Signal (2005) 1.79
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun (2005) 1.74
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
A novel fatty Acyl-CoA Synthetase is required for pollen development and sporopollenin biosynthesis in Arabidopsis. Plant Cell (2009) 1.70
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol (2013) 1.70
Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci (2010) 1.70
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J Biol Chem (2003) 1.68
Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci (2010) 1.67
Mitochondria-targeted small molecule therapeutics and probes. Antioxid Redox Signal (2011) 1.66
Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem (2006) 1.65
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med (2009) 1.62
Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS (2007) 1.62
Retracted Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver. Proc Natl Acad Sci U S A (2013) 1.59
Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem (2005) 1.58
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol (2012) 1.55
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med (2008) 1.55
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells. Cell Cycle (2009) 1.54
Adhesion of biologically inspired vertical and angled polymer microfiber arrays. Langmuir (2007) 1.54
A complication from neurocranial restructuring: nasal septum fracture. Arch Otolaryngol Head Neck Surg (2003) 1.53
Mitochondrial pharmacology. Trends Pharmacol Sci (2012) 1.51
Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epithelial cells. Photochem Photobiol (2004) 1.50
A redox switch in angiotensinogen modulates angiotensin release. Nature (2010) 1.50
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
Choroidal thickness, age, and refractive error in healthy Korean subjects. Optom Vis Sci (2014) 1.46
Estimating the risk of solid organ malignancy in patients undergoing routine computed tomography scans after endovascular aneurysm repair. J Vasc Surg (2012) 1.46
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis (2008) 1.46
Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med (2007) 1.45
Usefulness of Alcohol-screening Instruments in Detecting Problem Drinking among Elderly Male Drinkers. Korean J Fam Med (2012) 1.45
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. J Neurosci (2005) 1.44
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord (2007) 1.44
Antiplatelet and anticoagulation therapy in vitreoretinal surgery. Am J Ophthalmol (2011) 1.43
Femoral arterial access management for endovascular aortic aneurysm repair: evolution and outcome. Perspect Vasc Surg Endovasc Ther (2009) 1.42
Use of animals by NATO countries in military medical training exercises: an international survey. Mil Med (2012) 1.42
[Expression of peroxisome proliferator-activated receptor (PPAR) gamma in Helicobacter pylori-infected gastric epithelium]. Korean J Gastroenterol (2007) 1.41
The function of p27 KIP1 during tumor development. Exp Mol Med (2009) 1.41
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med (2013) 1.39
Cartilage intermediate layer protein (CILP) regulation in intervertebral discs. The effect of age, degeneration, and bone morphogenetic protein-2. Spine (Phila Pa 1976) (2012) 1.39
Influence of topical bimatoprost on macular thickness and volume in glaucoma patients with phakic eyes. Can J Ophthalmol (2008) 1.39
Dialysis access steal syndromes. Perspect Vasc Surg Endovasc Ther (2009) 1.38
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem (2007) 1.38
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol (2009) 1.37
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J Biol Chem (2008) 1.36
How mitochondrial damage affects cell function. J Biomed Sci (2002) 1.34
Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution. Yonsei Med J (2008) 1.34
Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biol (2013) 1.34
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33
Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res (2009) 1.31
Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett (2006) 1.31
Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancer Lett (2003) 1.31
5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem Biophys Res Commun (2004) 1.29
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J (2008) 1.28
Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J (2010) 1.28
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol (2006) 1.28
Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology (2011) 1.27
The carboxy terminal C-tail of BNip3 is crucial in induction of mitochondrial permeability transition in isolated mitochondria. Arch Biochem Biophys (2002) 1.26
Mitochondrial redox signalling at a glance. J Cell Sci (2012) 1.26
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.26
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med (2008) 1.24
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
Prediction of Gleason score upgrading in low-risk prostate cancers diagnosed via multi (> or = 12)-core prostate biopsy. World J Urol (2008) 1.23
Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis. Plant Cell (2010) 1.23