Published in FASEB J on October 05, 2005
The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol (2010) 1.52
Role of erythropoietin in the brain. Crit Rev Oncol Hematol (2007) 1.50
Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med (2008) 1.36
Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. Am J Physiol Heart Circ Physiol (2009) 1.32
Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res (2008) 1.25
Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res (2006) 1.22
Erythropoietin: a multimodal neuroprotective agent. Exp Transl Stroke Med (2009) 1.14
Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS One (2013) 1.08
Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function. Physiology (Bethesda) (2014) 1.07
Role of Nogo-A in neuronal survival in the reperfused ischemic brain. J Cereb Blood Flow Metab (2010) 1.06
Erythropoietin in the intensive care unit: beyond treatment of anemia. Ann Intensive Care (2011) 1.03
Involvement of erythropoietin in retinal ischemic preconditioning. Anesthesiology (2009) 0.97
Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis (2010) 0.97
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci (2014) 0.96
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801. Br J Pharmacol (2011) 0.95
Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling. J Neurosci (2012) 0.95
Erythropoietin: new directions for the nervous system. Int J Mol Sci (2012) 0.95
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways. PLoS One (2012) 0.95
Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade. Int J Mol Sci (2012) 0.94
Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience (2011) 0.92
Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis (2014) 0.90
Erythropoietin: still on the neuroprotection road. Ther Adv Neurol Disord (2012) 0.90
Mutant erythropoietin without erythropoietic activity is neuroprotective against ischemic brain injury. Stroke (2012) 0.88
Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection. Pediatr Neurol (2014) 0.88
Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases. Endocrinology (2008) 0.87
Erythropoietin: powerful protection of ischemic and post-ischemic brain. Exp Biol Med (Maywood) (2014) 0.87
Erythropoietin in brain development and beyond. Anat Res Int (2012) 0.86
The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a rat model of traumatic brain injury. J Cereb Blood Flow Metab (2009) 0.85
Erythropoietin neuroprotection with traumatic brain injury. Pathophysiology (2012) 0.85
Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats. Mol Pain (2011) 0.83
Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia. Funct Integr Genomics (2010) 0.83
Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation. Oncotarget (2015) 0.83
Recombinant Human Erythropoietin: Novel Strategies for Neuroprotective/Neuro-regenerative Treatment of Multiple Sclerosis. Ther Adv Neurol Disord (2008) 0.82
Growth factors for the treatment of ischemic brain injury (growth factor treatment). Brain Sci (2015) 0.81
BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells. Mol Cell Neurosci (2012) 0.80
Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat. Inflammation (2015) 0.80
Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79
Experimental studies of erythropoietin protection following traumatic brain injury in rats. Exp Ther Med (2012) 0.78
Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis. J Neuropathol Exp Neurol (2014) 0.78
Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. Brain Res (2008) 0.78
Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury. Neural Regen Res (2015) 0.77
Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels. Cell Death Dis (2010) 0.76
Perinatal brain damage: The term infant. Neurobiol Dis (2015) 0.76
A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects. Mar Drugs (2016) 0.75
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. Mol Med (2013) 0.75
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection. Br J Pharmacol (2017) 0.75
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol (2017) 0.75
The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage. Cell Death Dis (2017) 0.75
Bi-directionally protective communication between neurons and astrocytes under ischemia. Redox Biol (2017) 0.75
Neuroprotective mechanisms of miR-124 activating PI3K/Akt signaling pathway in ischemic stroke. Exp Ther Med (2017) 0.75
Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats. Transl Stroke Res (2017) 0.75
Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis. Korean J Pediatr (2017) 0.75
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med (2002) 2.69
The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function. Exp Physiol (2012) 2.20
Air quality, stroke, and coronary events: results of the Heinz Nixdorf Recall Study from the Ruhr Region. Dtsch Arztebl Int (2015) 2.10
Sleep-disordered breathing and periodic limb movements in narcolepsy with cataplexy: a systematic analysis of 35 consecutive patients. Eur Neurol (2013) 2.05
Serum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis. Med Princ Pract (2014) 1.99
Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate. Eur J Appl Physiol (2009) 1.99
Violence in sleep. Brain (2010) 1.92
Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain (2009) 1.89
Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res (2004) 1.88
Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity (2002) 1.87
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
Validation of the fatigue severity scale in a Swiss cohort. Sleep (2008) 1.72
Sleep-wake disturbances 3 years after traumatic brain injury. J Neurol Neurosurg Psychiatry (2010) 1.71
Erythropoietin enhances immune responses in mice. Eur J Immunol (2007) 1.68
VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain (2004) 1.67
The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J (2006) 1.64
Sleep-wake disturbances 6 months after traumatic brain injury: a prospective study. Brain (2007) 1.64
Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia. J Physiol (2007) 1.56
Functional NMDA receptors in rat erythrocytes. Am J Physiol Cell Physiol (2010) 1.54
Loss of hypocretin (orexin) neurons with traumatic brain injury. Ann Neurol (2009) 1.54
Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res (2006) 1.54
Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J (2003) 1.53
TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis (2008) 1.52
Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A (2010) 1.49
Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep (2006) 1.48
Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models. J Physiol (2011) 1.46
Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1. Neurobiol Dis (2005) 1.45
Sleep-related breathing and sleep-wake disturbances in ischemic stroke. Neurology (2009) 1.39
Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice. Proc Natl Acad Sci U S A (2009) 1.37
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J (2003) 1.36
Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J (2002) 1.36
Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci (2007) 1.31
Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci (2006) 1.31
Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain (2011) 1.29
Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci (2004) 1.27
Differentiating embryonic stem cells into embryoid bodies. Methods Mol Biol (2004) 1.26
Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J (2004) 1.25
The clinical spectrum of narcolepsy with cataplexy: a reappraisal. J Sleep Res (2004) 1.24
Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Brain (2007) 1.24
HIFs and tumors--causes and consequences. Am J Physiol Regul Integr Comp Physiol (2004) 1.23
Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood (2003) 1.22
Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism. Circ Res (2011) 1.22
Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor. Cancer Res (2002) 1.20
Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors. FASEB J (2002) 1.20
Animal models of ischemic stroke. Part two: modeling cerebral ischemia. Open Neurol J (2010) 1.18
Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis Rheum (2004) 1.17
Sensing and responding to hypoxia via HIF in model invertebrates. J Insect Physiol (2006) 1.17
Dissociation of periodic leg movements from arousals in restless legs syndrome. Ann Neurol (2012) 1.14
Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF(165) in the brain. Neuroimage (2007) 1.14
MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. Acta Neuropathol (2013) 1.13
Morphological differences in Parkinson's disease with and without rest tremor. J Neurol (2009) 1.12
Rescue of lethal c-KitW/W mice by erythropoietin. Blood (2004) 1.12
Excessive erythrocytosis compromises the blood-endothelium interface in erythropoietin-overexpressing mice. J Physiol (2011) 1.11
Central necrosis in isolated hypoxic human pancreatic islets: evidence for postisolation ischemia. Cell Transplant (2005) 1.11
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nat Neurosci (2006) 1.10
S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity. J Biol Chem (2012) 1.09
Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing. Stroke (2013) 1.08
Macrophages as novel target cells for erythropoietin. Haematologica (2010) 1.08
Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J Cereb Blood Flow Metab (2010) 1.08
c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation (2008) 1.08
Abnormal activity in reward brain circuits in human narcolepsy with cataplexy. Ann Neurol (2010) 1.07
Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss? Brain (2010) 1.07
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. J Endocrinol (2010) 1.07
Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions. Eur J Appl Physiol (2005) 1.07
Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke (2007) 1.06
Hypocretins (orexins) and sleep-wake disorders. Lancet Neurol (2005) 1.06
Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res (2005) 1.06
Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells. Mol Immunol (2008) 1.06
When melatonin gets on your nerves: its beneficial actions in experimental models of stroke. Exp Biol Med (Maywood) (2005) 1.06
Role of Nogo-A in neuronal survival in the reperfused ischemic brain. J Cereb Blood Flow Metab (2010) 1.06
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol Chem (2005) 1.06
Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin. Blood (2007) 1.05
Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species. J Cell Sci (2006) 1.05
Erythropoietin-induced excessive erythrocytosis activates the tissue endothelin system in mice. FASEB J (2002) 1.05
Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. J Pineal Res (2008) 1.05
Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice. Ann Neurol (2002) 1.04
Non-erythroid functions of erythropoietin. Adv Exp Med Biol (2003) 1.04