Published in Nature on October 12, 2005
Prevalence and evolution of core photosystem II genes in marine cyanobacterial viruses and their hosts. PLoS Biol (2006) 3.63
Ecological genomics of marine picocyanobacteria. Microbiol Mol Biol Rev (2009) 3.62
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature (2013) 3.02
The Sorcerer II Global Ocean Sampling Expedition: metagenomic characterization of viruses within aquatic microbial samples. PLoS One (2008) 2.91
Viruses manipulate the marine environment. Nature (2009) 2.86
Phosphate acquisition genes in Prochlorococcus ecotypes: evidence for genome-wide adaptation. Proc Natl Acad Sci U S A (2006) 2.78
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Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. Nat Struct Mol Biol (2010) 2.12
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Photosystem I gene cassettes are present in marine virus genomes. Nature (2009) 1.95
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A simple and efficient method for concentration of ocean viruses by chemical flocculation. Environ Microbiol Rep (2011) 1.64
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Metagenomic exploration of viruses throughout the Indian Ocean. PLoS One (2012) 1.23
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The not so universal tree of life or the place of viruses in the living world. Philos Trans R Soc Lond B Biol Sci (2009) 1.17
Metabolic reprogramming by viruses in the sunlit and dark ocean. Genome Biol (2013) 1.16
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Ma-LMM01 infecting toxic Microcystis aeruginosa illuminates diverse cyanophage genome strategies. J Bacteriol (2007) 1.11
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Depth-stratified functional and taxonomic niche specialization in the 'core' and 'flexible' Pacific Ocean Virome. ISME J (2014) 1.08
Single-cell and population level viral infection dynamics revealed by phageFISH, a method to visualize intracellular and free viruses. Environ Microbiol (2013) 1.08
Dynamic viral populations in hypersaline systems as revealed by metagenomic assembly. Appl Environ Microbiol (2012) 1.06
Intertwined evolutionary histories of marine Synechococcus and Prochlorococcus marinus. Genome Biol Evol (2009) 1.06
Modeling the fitness consequences of a cyanophage-encoded photosynthesis gene. PLoS One (2008) 1.06
A novel lineage of myoviruses infecting cyanobacteria is widespread in the oceans. Proc Natl Acad Sci U S A (2012) 1.03
A bioinformatic analysis of ribonucleotide reductase genes in phage genomes and metagenomes. BMC Evol Biol (2013) 1.01
Cyanobacterial psbA gene family: optimization of oxygenic photosynthesis. Cell Mol Life Sci (2009) 1.00
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Capture and analysis of quantitative proteomic data. Proteomics (2007) 0.96
Intracellular assembly of cyanophage Syn5 proceeds through a scaffold-containing procapsid. J Virol (2010) 0.95
Comparative metagenomic analyses reveal viral-induced shifts of host metabolism towards nucleotide biosynthesis. Microbiome (2014) 0.92
Laccase: enzyme revisited and function redefined. Indian J Microbiol (2008) 0.91
Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean. Plant Cell (2014) 0.91
From green to red: horizontal gene transfer of the phycoerythrin gene cluster between Planktothrix strains. Appl Environ Microbiol (2013) 0.90
Cyanophage tRNAs may have a role in cross-infectivity of oceanic Prochlorococcus and Synechococcus hosts. ISME J (2011) 0.90
A freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages. Environ Microbiol (2011) 0.89
Genetic diversity in cultured and wild marine cyanomyoviruses reveals phosphorus stress as a strong selective agent. ISME J (2013) 0.89
Marine cyanophages: tinkering with the electron transport chain. ISME J (2011) 0.89
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ProViDE: A software tool for accurate estimation of viral diversity in metagenomic samples. Bioinformation (2011) 0.88
Reconstruction of novel cyanobacterial siphovirus genomes from Mediterranean metagenomic fosmids. Appl Environ Microbiol (2012) 0.88
UV hyper-resistance in Prochlorococcus MED4 results from a single base pair deletion just upstream of an operon encoding nudix hydrolase and photolyase. Environ Microbiol (2010) 0.88
Proteorhodopsin genes in giant viruses. Biol Direct (2012) 0.87
Evolution of a divinyl chlorophyll-based photosystem in Prochlorococcus. Proc Natl Acad Sci U S A (2011) 0.86
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High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection. ISME J (2016) 0.86
Viral clones from the GOS expedition with an unusual photosystem-I gene cassette organization. ISME J (2012) 0.86
Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes. PeerJ (2016) 0.85
Biodiversity and distribution of polar freshwater DNA viruses. Sci Adv (2015) 0.84
A novel cyanophage with a cyanobacterial nonbleaching protein A gene in the genome. J Virol (2011) 0.84
The RNA polymerase of marine cyanophage Syn5. J Biol Chem (2012) 0.84
Transcriptome dynamics of a broad host-range cyanophage and its hosts. ISME J (2015) 0.83
Rhizome of life, catastrophes, sequence exchanges, gene creations, and giant viruses: how microbial genomics challenges Darwin. Front Cell Infect Microbiol (2012) 0.83
Phylogenetic and gene expression analysis of cyanobacteria and diatoms in the twilight waters of the temperate northeast Pacific Ocean. Microb Ecol (2011) 0.83
Bacteriophage behavioral ecology: How phages alter their bacterial host's habits. Bacteriophage (2014) 0.82
A gene island with two possible configurations is involved in chromatic acclimation in marine Synechococcus. PLoS One (2013) 0.82
Evolutionary strategies of viruses, bacteria and archaea in hydrothermal vent ecosystems revealed through metagenomics. PLoS One (2014) 0.81
The P-SSP7 cyanophage has a linear genome with direct terminal repeats. PLoS One (2012) 0.80
Diurnal infection patterns and impact of Microcystis cyanophages in a Japanese pond. Appl Environ Microbiol (2012) 0.80
Metagenomic Analysis of Virioplankton of the Subtropical Jiulong River Estuary, China. Viruses (2016) 0.79
Structure and function of a cyanophage-encoded peptide deformylase. ISME J (2013) 0.79
Clade-Specific Quantitative Analysis of Photosynthetic Gene Expression in Prochlorococcus. PLoS One (2015) 0.78
Detection of virus mRNA within infected host cells using an isothermal nucleic acid amplification assay: marine cyanophage gene expression within Synechococcus sp. Virol J (2007) 0.78
Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean. ISME J (2016) 0.78
Prevalence of viral photosynthetic and capsid protein genes from cyanophages in two large and deep perialpine lakes. Appl Environ Microbiol (2013) 0.78
Cyanophage infection in the bloom-forming cyanobacteria Microcystis aeruginosa in surface freshwater. Microbes Environ (2012) 0.78
Marine microbial metagenomics: from individual to the environment. Int J Mol Sci (2014) 0.78
Comparative Genomic and Phylogenomic Analyses Reveal a Conserved Core Genome Shared by Estuarine and Oceanic Cyanopodoviruses. PLoS One (2015) 0.78
Adventures with cyanobacteria: a personal perspective. Front Plant Sci (2011) 0.77
Diversity of viral photosystem-I psaA genes. ISME J (2014) 0.77
Virus evolution toward limited dependence on nonessential functions of the host: the case of bacteriophage SPP1. J Virol (2014) 0.76
Two novel proteins of cyanophage Syn5 compose its unusual horn structure. J Virol (2013) 0.76
Prevalence of psbA-containing cyanobacterial podoviruses in the ocean. Sci Rep (2013) 0.76
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (2009) 21.24
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
Multiplex amplification of large sets of human exons. Nat Methods (2007) 15.11
Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29
Community genomics among stratified microbial assemblages in the ocean's interior. Science (2006) 13.31
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Clinical assessment incorporating a personal genome. Lancet (2010) 10.18
Advanced sequencing technologies: methods and goals. Nat Rev Genet (2004) 9.31
Modular epistasis in yeast metabolism. Nat Genet (2004) 8.64
Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation. Nature (2003) 8.53
Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A (2002) 8.41
Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset. Genome Biol (2005) 8.32
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res (2013) 7.77
Sequencing genomes from single cells by polymerase cloning. Nat Biotechnol (2006) 7.64
Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science (2009) 6.96
A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91
Cas9 as a versatile tool for engineering biology. Nat Methods (2013) 6.87
Microbial community gene expression in ocean surface waters. Proc Natl Acad Sci U S A (2008) 6.50
From genetic privacy to open consent. Nat Rev Genet (2008) 5.95
Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods (2013) 5.93
Niche partitioning among Prochlorococcus ecotypes along ocean-scale environmental gradients. Science (2006) 5.58
The brain activity map project and the challenge of functional connectomics. Neuron (2012) 5.52
Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22
Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science (2007) 5.19
Genomic islands and the ecology and evolution of Prochlorococcus. Science (2006) 5.07
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06
A logic-gated nanorobot for targeted transport of molecular payloads. Science (2012) 4.96
Unlocking short read sequencing for metagenomics. PLoS One (2010) 4.88
Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors. Nucleic Acids Res (2002) 4.83
Whole genome amplification and de novo assembly of single bacterial cells. PLoS One (2009) 4.65
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods (2013) 4.61
Genome engineering. Nat Biotechnol (2009) 4.60
Cyanophages infecting the oceanic cyanobacterium Prochlorococcus. Nature (2003) 4.57
Three Prochlorococcus cyanophage genomes: signature features and ecological interpretations. PLoS Biol (2005) 4.55
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range. Proc Natl Acad Sci U S A (2002) 4.44
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods (2009) 4.38
Resolution of Prochlorococcus and Synechococcus ecotypes by using 16S-23S ribosomal DNA internal transcribed spacer sequences. Appl Environ Microbiol (2002) 4.35
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25
Tuberculosis drug resistance mutation database. PLoS Med (2009) 4.13
Emergent biogeography of microbial communities in a model ocean. Science (2007) 4.03
Genome-scale metabolic model of Helicobacter pylori 26695. J Bacteriol (2002) 4.00
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol (2013) 3.84
Highly multiplexed subcellular RNA sequencing in situ. Science (2014) 3.77
Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature (2012) 3.74
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proc Natl Acad Sci U S A (2006) 3.68
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol (2006) 3.68
Prevalence and evolution of core photosystem II genes in marine cyanobacterial viruses and their hosts. PLoS Biol (2006) 3.63
The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation. Mol Cell (2011) 3.61
Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics (2009) 3.50
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science (2011) 3.49
Bacteria subsisting on antibiotics. Science (2008) 3.47
Information access. Raw personal data: providing access. Science (2014) 3.41
Transfer of photosynthesis genes to and from Prochlorococcus viruses. Proc Natl Acad Sci U S A (2004) 3.38
Neuroscience. The brain activity map. Science (2013) 3.36
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
The complete genome and proteome of Mycoplasma mobile. Genome Res (2004) 3.36
The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature (2011) 3.32
Computational discovery of sense-antisense transcription in the human and mouse genomes. Genome Biol (2002) 3.28
Gene synthesis by circular assembly amplification. Nat Methods (2007) 3.21
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips. Nat Biotechnol (2010) 3.14
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res (2010) 3.08
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A (2012) 3.06
The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting. Mol Cell (2006) 2.99
Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation. Genome Res (2003) 2.97
Bacterial vesicles in marine ecosystems. Science (2014) 2.94
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic Acids Res (2009) 2.91
The challenges of sequencing by synthesis. Nat Biotechnol (2009) 2.89
Microbial community transcriptomes reveal microbes and metabolic pathways associated with dissolved organic matter turnover in the sea. Proc Natl Acad Sci U S A (2010) 2.82
Phosphate acquisition genes in Prochlorococcus ecotypes: evidence for genome-wide adaptation. Proc Natl Acad Sci U S A (2006) 2.78
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
Digital genotyping and haplotyping with polymerase colonies. Proc Natl Acad Sci U S A (2003) 2.77
Proteogenomic mapping as a complementary method to perform genome annotation. Proteomics (2004) 2.76
Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Genome Res (2002) 2.74
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Genomically recoded organisms expand biological functions. Science (2013) 2.73
Fluorescent in situ sequencing on polymerase colonies. Anal Biochem (2003) 2.70
High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing. Nat Biotechnol (2010) 2.68
Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus. Science (2014) 2.58
The amino-acid mutational spectrum of human genetic disease. Genome Biol (2003) 2.55
Towards synthesis of a minimal cell. Mol Syst Biol (2006) 2.55
Identification of foreign gene sequences by transcript filtering against the human genome. Nat Genet (2002) 2.52
Southern Ocean iron enrichment experiment: carbon cycling in high- and low-Si waters. Science (2004) 2.43
Regulatory network of acid resistance genes in Escherichia coli. Mol Microbiol (2003) 2.42
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell (2012) 2.42
Multiplex padlock targeted sequencing reveals human hypermutable CpG variations. Genome Res (2009) 2.38
Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature (2007) 2.27