Published in Science on May 29, 2009
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 18.08
Computation for ChIP-seq and RNA-seq studies. Nat Methods (2009) 16.11
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Widespread RNA and DNA sequence differences in the human transcriptome. Science (2011) 11.45
RNA sequencing: advances, challenges and opportunities. Nat Rev Genet (2010) 8.96
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The impact of retrotransposons on human genome evolution. Nat Rev Genet (2009) 8.08
Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem (2010) 5.99
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A single-base resolution map of an archaeal transcriptome. Genome Res (2009) 3.42
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips. Nat Biotechnol (2010) 3.14
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Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70
Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts. Genome Biol (2009) 2.65
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Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature (2014) 2.49
Accurate identification of human Alu and non-Alu RNA editing sites. Nat Methods (2012) 2.47
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The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs. Nat Struct Mol Biol (2011) 2.04
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer (2011) 2.02
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A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut (2013) 1.80
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High-throughput sequencing for biology and medicine. Mol Syst Biol (2013) 1.75
Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome Biol (2012) 1.68
A-to-I RNA editing: effects on proteins key to neural excitability. Neuron (2012) 1.52
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The APOBEC3 family of retroelement restriction factors. Curr Top Microbiol Immunol (2013) 1.46
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Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. Nat Struct Mol Biol (2013) 1.42
Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing. Nat Rev Genet (2010) 1.40
Large-scale detection and analysis of RNA editing in grape mtDNA by RNA deep-sequencing. Nucleic Acids Res (2010) 1.39
The ADAR protein family. Genome Biol (2012) 1.39
Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci (2014) 1.35
Systematic identification of edited microRNAs in the human brain. Genome Res (2012) 1.35
New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes. Genome Res (2011) 1.32
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron (2012) 1.27
Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. Genome Biol (2014) 1.26
Deciphering the functions and regulation of brain-enriched A-to-I RNA editing. Nat Neurosci (2013) 1.25
The complex transcriptional landscape of the anucleate human platelet. BMC Genomics (2013) 1.23
Competition between ADAR and RNAi pathways for an extensive class of RNA targets. Nat Struct Mol Biol (2011) 1.22
Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs. PLoS Genet (2013) 1.22
Performance of microarray and liquid based capture methods for target enrichment for massively parallel sequencing and SNP discovery. PLoS One (2011) 1.21
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. Cell Rep (2015) 1.21
ADAR regulates RNA editing, transcript stability, and gene expression. Cell Rep (2013) 1.19
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Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing. Nat Methods (2013) 1.19
RNA editing of protein sequences: a rare event in human transcriptomes. RNA (2012) 1.18
RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci U S A (2010) 1.17
Human brain evolution: transcripts, metabolites and their regulators. Nat Rev Neurosci (2013) 1.16
Identification of widespread ultra-edited human RNAs. PLoS Genet (2011) 1.16
Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing. PLoS One (2010) 1.15
A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol (2015) 1.14
Linking genes to diseases: it's all in the data. Genome Med (2009) 1.14
Linear motifs confer functional diversity onto splice variants. Nucleic Acids Res (2012) 1.13
High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies. Cell (2014) 1.13
Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nat Protoc (2015) 1.12
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Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. PLoS One (2012) 1.11
Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis. Neurobiol Dis (2010) 1.11
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Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs. Genome Res (2012) 1.06
Dynamic landscape and regulation of RNA editing in mammals. Nature (2017) 1.06
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. Proc Natl Acad Sci U S A (2014) 1.05
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. J Biol Chem (2011) 1.05
Evolution of exon-intron structure and alternative splicing. PLoS One (2011) 1.04
A genome-wide map of hyper-edited RNA reveals numerous new sites. Nat Commun (2014) 1.04
A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. RNA Biol (2013) 1.04
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. Oncogene (2012) 1.04
RNA editome in rhesus macaque shaped by purifying selection. PLoS Genet (2014) 1.02
Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats. BMC Genomics (2010) 1.02
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol (2012) 1.01
Targeted sequencing for gene discovery and quantification using RNA CaptureSeq. Nat Protoc (2014) 1.01
Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. Nucleic Acids Res (2010) 1.00
Synergy of homocysteine, microRNA, and epigenetics: a novel therapeutic approach for stroke. Mol Neurobiol (2013) 1.00
Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nat Commun (2012) 0.99
From cis-regulatory elements to complex RNPs and back. Cold Spring Harb Perspect Biol (2012) 0.98
Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis. Plant Cell (2015) 0.98
Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR). RNA (2013) 0.98
The emerging role of epigenetics in stroke: II. RNA regulatory circuitry. Arch Neurol (2010) 0.98
RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II. Cell Rep (2014) 0.97
Alu elements shape the primate transcriptome by cis-regulation of RNA editing. Genome Biol (2014) 0.97
Transcriptome analysis of microRNAs in developing cerebral cortex of rat. BMC Genomics (2012) 0.96
Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med (2011) 0.96
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (2009) 21.24
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
Multiplex amplification of large sets of human exons. Nat Methods (2007) 15.11
Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29
MOM: maximum oligonucleotide mapping. Bioinformatics (2009) 13.75
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Interrogating a high-density SNP map for signatures of natural selection. Genome Res (2002) 10.33
Clinical assessment incorporating a personal genome. Lancet (2010) 10.18
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
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Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol (2003) 8.54
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Sequencing genomes from single cells by polymerase cloning. Nat Biotechnol (2006) 7.64
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91
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Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A (2008) 5.94
Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods (2013) 5.93
The brain activity map project and the challenge of functional connectomics. Neuron (2012) 5.52
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Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science (2007) 5.19
A logic-gated nanorobot for targeted transport of molecular payloads. Science (2012) 4.96
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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods (2013) 4.61
Genome engineering. Nat Biotechnol (2009) 4.60
Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell (2008) 4.52
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range. Proc Natl Acad Sci U S A (2002) 4.44
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods (2009) 4.38
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Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell (2010) 4.28
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25
Tuberculosis drug resistance mutation database. PLoS Med (2009) 4.13
Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Science (2009) 4.13
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell (2012) 4.03
Genome-scale metabolic model of Helicobacter pylori 26695. J Bacteriol (2002) 4.00
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol (2013) 3.84
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Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature (2012) 3.74
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proc Natl Acad Sci U S A (2006) 3.68
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol (2006) 3.68
The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation. Mol Cell (2011) 3.61
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature (2011) 3.56
Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics (2009) 3.50
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science (2011) 3.49
Bacteria subsisting on antibiotics. Science (2008) 3.47
Patient navigation and case management following an abnormal mammogram: a randomized clinical trial. Prev Med (2006) 3.45
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The complete genome and proteome of Mycoplasma mobile. Genome Res (2004) 3.36
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