Published in Cell on August 08, 2003
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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev (2003) 3.67
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell (2006) 3.62
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ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell (2005) 2.13
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Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
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Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol (2008) 1.66
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J (2007) 1.65
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Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood (2007) 1.61
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol (2005) 1.56
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis. Cell Prolif (2005) 1.56
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1. Cancer Res (2005) 1.50
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett (2008) 1.50
A common gain of function of p53 cancer mutants in inducing genetic instability. Oncogene (2009) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
Histone variant H2ABbd confers lower stability to the nucleosome. EMBO Rep (2004) 1.49
Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med (2004) 1.49
Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div (2006) 1.47
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Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer (2012) 1.45
Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene (2007) 1.44
Histone variants in metazoan development. Dev Cell (2010) 1.42
Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A (2008) 1.42
p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A (2006) 1.41
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A (2006) 1.38
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. J Exp Med (2007) 1.37
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med (2010) 1.36
DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. Cell Death Dis (2012) 1.35
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
Double strand break repair functions of histone H2AX. Mutat Res (2013) 1.31
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31
Molecular analysis of sister chromatid recombination in mammalian cells. DNA Repair (Amst) (2005) 1.30
INO80 subfamily of chromatin remodeling complexes. Mutat Res (2007) 1.29
Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem (2011) 1.29
H2AX regulates meiotic telomere clustering. J Cell Biol (2003) 1.27
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol (2008) 1.23
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
A peek into the complex realm of histone phosphorylation. Mol Cell Biol (2011) 1.22
A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med (2007) 1.22
Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome. EMBO J (2006) 1.20
Regulation of histone modification and chromatin structure by the p53-PADI4 pathway. Nat Commun (2012) 1.20
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood (2009) 1.19
Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin Cancer Res (2010) 1.18
Histone variants: emerging players in cancer biology. Cell Mol Life Sci (2013) 1.17
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13
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Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins. Breast Cancer Res (2010) 1.09
Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res (2009) 1.08
Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol (2005) 1.07
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature (2015) 1.05
DNA damage response pathways in tumor suppression and cancer treatment. World J Surg (2009) 1.05
Global variation in copy number in the human genome. Nature (2006) 57.50
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science (2005) 39.06
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science (2007) 32.68
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89
Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet (2010) 13.70
Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
EMBL Nucleotide Sequence Database in 2006. Nucleic Acids Res (2006) 9.72
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res (2008) 9.29
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Copy number variation: new insights in genome diversity. Genome Res (2006) 8.66
Diet and the evolution of human amylase gene copy number variation. Nat Genet (2007) 8.64
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell (2010) 7.78
TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res (2006) 7.61
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Genome assembly comparison identifies structural variants in the human genome. Nat Genet (2006) 6.93
A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Challenges and standards in integrating surveys of structural variation. Nat Genet (2007) 6.05
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays. Genome Res (2006) 5.97
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
EMBL Nucleotide Sequence Database: developments in 2005. Nucleic Acids Res (2006) 5.13
The fine-scale and complex architecture of human copy-number variation. Am J Hum Genet (2008) 5.08
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science (2005) 4.75
Completing the map of human genetic variation. Nature (2007) 4.38
Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68
Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci U S A (2006) 3.68
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Mutation spectrum revealed by breakpoint sequencing of human germline CNVs. Nat Genet (2010) 3.52
Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing. Nat Genet (2010) 3.49
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
A p53-dependent checkpoint pathway prevents rereplication. Mol Cell (2003) 3.42
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell (2008) 3.42
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. Hepatology (2014) 3.31
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol (2011) 3.25
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Distinct genomic aberrations associated with ERG rearranged prostate cancer. Genes Chromosomes Cancer (2009) 3.03
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res (2007) 2.97
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Temporal profile of replication of human chromosomes. Proc Natl Acad Sci U S A (2005) 2.85
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
Towards a comprehensive structural variation map of an individual human genome. Genome Biol (2010) 2.79
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals. Nat Genet (2011) 2.74