Published in Nat Cell Biol on November 13, 2005
β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02
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The many facets of Notch ligands. Oncogene (2008) 2.57
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51
Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest (2006) 2.15
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A Notch updated. J Cell Biol (2009) 1.86
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83
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Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep (2006) 1.72
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Seven-transmembrane receptors and ubiquitination. Circ Res (2007) 1.52
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. Oncogene (2010) 1.38
AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One (2008) 1.35
Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors. PLoS Pathog (2010) 1.35
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci (2011) 1.20
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst (2011) 1.15
Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med (2012) 1.11
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol (2011) 1.11
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol (2012) 1.09
The arrestin fold: variations on a theme. Curr Genomics (2009) 1.09
Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol (2013) 1.03
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem (2010) 1.03
Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis. Mol Oncol (2009) 1.01
Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res (2010) 1.00
Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Curr Pharm Biotechnol (2009) 1.00
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol (2009) 1.00
beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? Br J Pharmacol (2009) 0.97
Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates. Endocrinology (2012) 0.94
Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1. Genetics (2013) 0.92
β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J (2010) 0.91
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. EMBO J (2011) 0.91
Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival. PLoS One (2013) 0.90
T cells develop normally in the absence of both Deltex1 and Deltex2. Mol Cell Biol (2006) 0.89
Modifiers of notch transcriptional activity identified by genome-wide RNAi. BMC Dev Biol (2010) 0.89
Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease. EMBO Rep (2015) 0.89
SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells. BMC Dev Biol (2010) 0.88
β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. Cancer Res (2015) 0.88
At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression. Mol Oncol (2009) 0.87
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless. Proc Natl Acad Sci U S A (2007) 0.85
A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo. J Cell Biol (2014) 0.85
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. PLoS Genet (2011) 0.85
Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci (2011) 0.84
Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis. J Clin Immunol (2007) 0.84
Ligand-Independent Mechanisms of Notch Activity. Trends Cell Biol (2015) 0.84
Planar cell polarity controls directional Notch signaling in the Drosophila leg. Development (2012) 0.83
Mapping the Deltex-binding surface on the notch ankyrin domain using analytical ultracentrifugation. J Mol Biol (2011) 0.83
NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol (2014) 0.83
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol (2012) 0.82
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res (2014) 0.82
FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba. PLoS One (2010) 0.79
Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Autophagy (2016) 0.79
The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation. PLoS One (2013) 0.77
Regulation of developmental processes: insights from mass spectrometry-based proteomics. Wiley Interdiscip Rev Dev Biol (2012) 0.76
Ral inhibits ligand-independent Notch signaling in Drosophila. Small GTPases (2012) 0.76
Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation. Mol Cell Biol (2009) 0.76
Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster. Genetics (2015) 0.75
A roadmap to understanding toll pathway changes: an educational primer for use with "regulation of toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1". Genetics (2014) 0.75
Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci U S A (2017) 0.75
Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest (2017) 0.75
The role of Notch signaling in the mammalian ovary. Reproduction (2017) 0.75
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev (2017) 0.75
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol (2004) 7.23
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol (2007) 6.56
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
Notch signalling in vertebrate neural development. Nat Rev Neurosci (2006) 4.97
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33
A protein complex network of Drosophila melanogaster. Cell (2011) 3.31
Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell (2011) 3.14
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A (2006) 2.92
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Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. J Neurosci (2008) 2.75
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell (2005) 2.75
Nanocourses: a short course format as an educational tool in a biological sciences graduate curriculum. CBE Life Sci Educ (2008) 2.39
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A (2009) 2.34
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol (2011) 2.25
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol (2007) 2.20
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Mol Cell (2013) 2.08
Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat Cell Biol (2008) 2.03
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol (2006) 1.91
A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A (2003) 1.86
Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 1.82
The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol (2004) 1.80
Notch signaling at a glance. J Cell Sci (2013) 1.76
Modeling spinal muscular atrophy in Drosophila. PLoS One (2008) 1.71
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem (2003) 1.69
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66
Transgenic rat model of Huntington's disease. Hum Mol Genet (2003) 1.66
The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity (2002) 1.66
p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. FEBS Lett (2002) 1.66
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J Biol Chem (2011) 1.63
Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development (2003) 1.61
Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol (2004) 1.59
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Effect of hypertonic saline dextran on acid-base balance in patients undergoing surgery of abdominal aortic aneurysm. Crit Care Med (2005) 1.47
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J (2004) 1.41
Down-regulation of Delta by proteolytic processing. J Cell Biol (2002) 1.37
Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study. J Neurosci (2007) 1.37
Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry. Dev Dyn (2005) 1.36
Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A (2008) 1.28
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nat Cell Biol (2013) 1.24
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum Mutat (2004) 1.22
Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics (2007) 1.19
Light-driven enantioselective organocatalysis. Angew Chem Int Ed Engl (2009) 1.18
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci (2003) 1.16
Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain. Neuroreport (2007) 1.13
Automated velocity mapping of migrating cell populations (AVeMap). Nat Methods (2012) 1.13
Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J (2013) 1.12
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. Biochemistry (2009) 1.12
Protein kinase C intervention: the state of play. Curr Opin Cell Biol (2009) 1.11
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol (2011) 1.11
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol (2003) 1.09
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A (2011) 1.08
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. Curr Biol (2004) 1.08
Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet (2010) 1.07
Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Hum Mol Genet (2008) 1.07
Medical student disaster medicine education: the development of an educational resource. Int J Emerg Med (2010) 1.06
CADASIL: a critical look at a Notch disease. Dev Neurosci (2006) 1.06
Caspase-8 sumoylation is associated with nuclear localization. Oncogene (2005) 1.06
Accessing the Exelixis collection. Nat Genet (2004) 1.06
Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development (2002) 1.06
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J (2012) 1.05
The Small GTPase RalA controls exocytosis of large dense core secretory granules by interacting with ARF6-dependent phospholipase D1. J Biol Chem (2005) 1.04
Tandem affinity purification in Drosophila: the advantages of the GS-TAP system. Fly (Austin) (2010) 1.03
Human protein-protein interaction networks and the value for drug discovery. Drug Discov Today (2007) 1.03
High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway. Mol Cancer Ther (2012) 1.03
IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules. Cardiovasc Res (2008) 1.03
The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biol Psychiatry (2010) 1.01
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol (2006) 1.01
Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A (2002) 1.00
In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J Cereb Blood Flow Metab (2010) 1.00
Sleep deprivation increases A(1) adenosine receptor density in the rat brain. Brain Res (2008) 1.00
Nodal points and complexity of Notch-Ras signal integration. Proc Natl Acad Sci U S A (2009) 0.99
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Autophagy (2014) 0.99
Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One (2013) 0.99
5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology (Berl) (2007) 0.98
Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. Proc Natl Acad Sci U S A (2006) 0.97
Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling. J Cell Biol (2011) 0.96
Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage. Soc Cogn Affect Neurosci (2008) 0.95
The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One (2013) 0.95
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell (2011) 0.94
Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. Proc Natl Acad Sci U S A (2003) 0.94
Changes in microcirculation as early markers for infection in preterm infants--an observational prospective study. Pediatr Res (2009) 0.93
Enantioselective intramolecular [2 + 2]-photocycloaddition reactions of 4-substituted quinolones catalyzed by a chiral sensitizer with a hydrogen-bonding motif. J Am Chem Soc (2011) 0.93
Normative database of the serotonergic system in healthy subjects using multi-tracer PET. Neuroimage (2012) 0.92
Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1. Genetics (2013) 0.92