Published in Cell Signal on June 01, 2009
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
The R-spondin protein family. Genome Biol (2012) 1.62
Cellular signaling and biological functions of R-spondins. Cell Signal (2011) 1.25
The structural basis of R-spondin recognition by LGR5 and RNF43. Genes Dev (2013) 1.11
The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol (2012) 1.09
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun (2013) 1.01
The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol (2011) 1.00
Crystal structures of Lgr4 and its complex with R-spondin1. Structure (2013) 0.97
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis. Mol Cell Biol (2013) 0.82
Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway. Biomed Res Int (2014) 0.76
Intrinsic disorder in spondins and some of their interacting partners. Intrinsically Disord Proteins (2016) 0.75
Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer. Cancers (Basel) (2016) 0.75
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature (2002) 5.61
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 5.45
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science (2005) 4.58
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38
R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet (2006) 3.92
Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol (2008) 3.87
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet (2006) 2.81
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell (2004) 2.73
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling. J Biol Chem (2007) 2.61
Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem (2006) 2.61
R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle (2006) 2.56
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol (2002) 2.28
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat Genet (2007) 2.14
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development (2008) 1.66
R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology (2007) 1.64
R-spondin3 is required for mouse placental development. Dev Biol (2006) 1.58
R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta (2004) 1.46
DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem (2008) 1.44
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol (2007) 1.40
Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns (2006) 1.30
Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia. Am J Hum Genet (2006) 1.30
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol (2007) 1.23
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett (2008) 1.11
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. Hum Mutat (2008) 1.05
Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. J Invest Dermatol (2007) 1.01
A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences. J Virol (2005) 0.99
RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4. J Invest Dermatol (2007) 0.94
R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ (2007) 0.93
Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR. Mol Biol Rep (2002) 0.89
Determination of glycosylation sites and disulfide bond structures using LC/ESI-MS/MS analysis. Methods Enzymol (2006) 0.86
R-spondin1 tips the balance in sex determination. Nat Genet (2006) 0.83
R-spondin1--discovery of the long-missing, mammalian female-determining gene? Bioessays (2007) 0.81
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (2003) 2.18
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol (2005) 1.79
Wnt signaling in B-cell neoplasia. Oncogene (2003) 1.73
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res (2004) 1.48
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res (2004) 1.45
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem (2004) 1.43
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J Clin Invest (2008) 1.39
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (2005) 1.31
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst (2006) 1.27
Combining results from lectin affinity chromatography and glycocapture approaches substantially improves the coverage of the glycoproteome. Mol Cell Proteomics (2008) 1.26
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogene (2005) 1.21
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res (2006) 1.14
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem (2001) 1.10
Electron cryomicroscopy reveals different F1+F2 protein States in intact parainfluenza virions. J Virol (2008) 1.10
Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Oncogene (2004) 1.08
Int6 expression can predict survival in early-stage non-small cell lung cancer patients. Clin Cancer Res (2005) 1.03
Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol (2009) 1.03
Disruption of Epstein-Barr virus latency in the absence of phosphorylation of ZEBRA by protein kinase C. J Virol (2002) 1.03
Proteins at membrane surfaces-a review of approaches. Mol Biosyst (2007) 1.00
Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer (2004) 1.00
Wnt signaling and neurite outgrowth: insights and questions. Cancer Sci (2007) 1.00
Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis. Am J Pathol (2005) 0.99
A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences. J Virol (2005) 0.99
Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo. J Cell Sci (2005) 0.99
Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns. J Proteome Res (2009) 0.99
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol (2008) 0.98
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res (2007) 0.98
Evaluation of two appropriateness criteria for total knee replacement. Arthritis Care Res (Hoboken) (2014) 0.98
The 3D structure of the fusion primed Sendai F-protein determined by electron cryomicroscopy. EMBO J (2003) 0.97
Identification of specific protein carbonylation sites in model oxidations of human serum albumin. J Am Soc Mass Spectrom (2006) 0.96
VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. Int J Biochem Cell Biol (2008) 0.95
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum (2002) 0.95
Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice. PLoS One (2012) 0.94
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol (2012) 0.92
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
Retrospective analysis of postinjection ultrasound imaging after platelet-rich plasma or autologous blood: observational review of anatomic distribution of injected material. AJR Am J Roentgenol (2012) 0.91
Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland. J Cell Physiol (2011) 0.90
Proteomic analysis of the extracellular matrix produced by mesenchymal stromal cells: implications for cell therapy mechanism. PLoS One (2013) 0.90
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells (2012) 0.90
Churg-strauss syndrome with eosinophilic myocarditis: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. HSS J (2012) 0.89
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC Cancer (2006) 0.87
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol (2008) 0.87
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochem Biophys Res Commun (2010) 0.86
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation. J Biol Chem (2008) 0.85
SFRP1 promoter methylation and expression in human trabecular meshwork cells. Exp Eye Res (2012) 0.84
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Arch Biochem Biophys (2011) 0.84
Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci (2011) 0.84
Stress fractures about the tibia, foot, and ankle. J Am Acad Orthop Surg (2012) 0.84
Eukaryotic glycosyltransferases: cysteines and disulfides. Glycobiology (2002) 0.82
Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation. J Biol Chem (2011) 0.82
Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides (2004) 0.81
An efficient algorithmic approach for mass spectrometry-based disulfide connectivity determination using multi-ion analysis. BMC Bioinformatics (2011) 0.81
Systemic alteration of cell-surface and secreted glycoprotein expression in malignant breast cancer cell lines. Glycobiology (2013) 0.80
Identification of the ZPC oligosaccharide ligand involved in sperm binding and the glycan structures of Xenopus laevis vitelline envelope glycoproteins. Biol Reprod (2003) 0.80
An eyelid mass caused by a migrated hard contact lens. Eye Contact Lens (2003) 0.80
Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells Dev (2010) 0.80
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem (2013) 0.79
An algorithmic approach to automated high-throughput identification of disulfide connectivity in proteins using tandem mass spectrometry. Comput Syst Bioinformatics Conf (2007) 0.79
Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesth Analg (2005) 0.79
Structural features of the lysosomal hydrolase mannose 6-phosphate uncovering enzyme. Glycoconj J (2005) 0.78
Purification and Wnt-inhibitory activities of secreted frizzled-related proteins. Methods Mol Biol (2008) 0.78
The role of centrosomal casein kinase 1 delta in neurite outgrowth and beyond. Cell Cycle (2011) 0.75
Lipid-enhancement of activated sludges obtained from conventional activated sludge and oxidation ditch processes. Bioresour Technol (2013) 0.75
Literature Reviews. Ultrasound Q (2015) 0.75
RECURRENT CENTRAL SEROUS CHORIORETINOPATHY ASSOCIATED WITH RETINITIS PIGMENTOSA TREATED WITH CARBONIC ANHYDRASE INHIBITORS. Retin Cases Brief Rep (2016) 0.75
Chest computed tomography features predictive of elevated B-type natriuretic peptide independent of renal function: diagnostic implications for evaluation of congestive heart failure. J Comput Assist Tomogr (2013) 0.75
Correction of multiplanar deformity of the second toe with metatarsophalangeal release and extensor brevis reconstruction. Foot Ankle Int (2013) 0.75
Diagnostic Accuracy of Zero-Echo Time MRI for the Evaluation of Cervical Neural Foraminal Stenosis. Spine (Phila Pa 1976) (2017) 0.75
Literature Reviews. Ultrasound Q (2017) 0.75
Literature Reviews. Ultrasound Q (2016) 0.75
Comparison of a fluoroscopic 3-dimensional imaging system and conventional CT in detection of pars fractures in the cadaveric lumbar spine. J Spinal Disord Tech (2012) 0.75
Literature Reviews. Ultrasound Q (2017) 0.75