Published in Cell on December 29, 2005
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32
MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat Rev Mol Cell Biol (2011) 3.52
MicroRNA regulatory networks in cardiovascular development. Dev Cell (2010) 3.09
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol (2008) 2.39
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res (2008) 2.32
Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods (2009) 2.32
A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions. PLoS One (2009) 2.24
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07
Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim Biophys Acta (2007) 1.97
miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res (2013) 1.94
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One (2009) 1.88
MicroRNA miR-328 regulates zonation morphogenesis by targeting CD44 expression. PLoS One (2008) 1.80
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol Cell (2010) 1.78
The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One (2008) 1.78
Context-dependent functions of specific microRNAs in neuronal development. Neural Dev (2010) 1.74
microRNAs and muscle disorders. J Cell Sci (2009) 1.73
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa. Genome Biol (2007) 1.67
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun (2013) 1.59
Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci (2007) 1.56
Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun (2007) 1.54
Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A (2008) 1.51
MicroRNA promoter element discovery in Arabidopsis. RNA (2006) 1.49
The biological functions of miRNAs: lessons from in vivo studies. Trends Cell Biol (2014) 1.47
Dicer is required for the transition from early to late progenitor state in the developing mouse retina. J Neurosci (2010) 1.46
Inter- and intra-combinatorial regulation by transcription factors and microRNAs. BMC Genomics (2007) 1.45
Analysis of regulatory network topology reveals functionally distinct classes of microRNAs. Nucleic Acids Res (2008) 1.36
Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J (2011) 1.36
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. PLoS One (2011) 1.34
microRNA control of cell-cell signaling during development and disease. Cell Cycle (2008) 1.32
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A (2013) 1.31
CRSD: a comprehensive web server for composite regulatory signature discovery. Nucleic Acids Res (2006) 1.30
Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies. Dev Biol (2007) 1.30
MicroRNA Gene Networks in Oncogenesis. Curr Genomics (2009) 1.26
Mirtrons: microRNA biogenesis via splicing. Biochimie (2011) 1.24
A potential role for intragenic miRNAs on their hosts' interactome. BMC Genomics (2010) 1.23
miRNA-transcription factor interactions: a combinatorial regulation of gene expression. Mol Genet Genomics (2013) 1.21
The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. Neoplasia (2009) 1.20
Lessons from microRNA mutants in worms, flies and mice. Cell Cycle (2008) 1.20
miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell (2013) 1.19
Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila. Nucleic Acids Res (2011) 1.19
MicroRNAs in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.19
The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells. Mol Endocrinol (2009) 1.17
MicroRNAs coordinately regulate protein complexes. BMC Syst Biol (2011) 1.17
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development (2012) 1.16
Insect microRNAs: biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol (2012) 1.15
Biological robustness and the role of microRNAs: a network perspective. Curr Top Dev Biol (2012) 1.14
The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans. PLoS Genet (2012) 1.13
Therapeutic microRNA strategies in human cancer. AAPS J (2009) 1.10
Prediction of microRNAs affecting mRNA expression during retinal development. BMC Dev Biol (2010) 1.08
MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1. Nucleic Acids Res (2010) 1.07
miTALOS: analyzing the tissue-specific regulation of signaling pathways by human and mouse microRNAs. RNA (2011) 1.05
Identification of microRNA-like RNAs in a plant pathogenic fungus Sclerotinia sclerotiorum by high-throughput sequencing. Mol Genet Genomics (2012) 1.05
MicroRNAs in cardiomyocyte development. Wiley Interdiscip Rev Syst Biol Med (2011) 1.04
Regulation of signalling by microRNAs. Biochem Soc Trans (2012) 1.02
Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives. Development (2010) 1.02
Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. Development (2008) 1.00
A view from Drosophila: multiple biological functions for individual microRNAs. Semin Cell Dev Biol (2010) 0.99
A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Genetics (2008) 0.99
MicroRNA targeting in mammalian genomes: genes and mechanisms. Wiley Interdiscip Rev Syst Biol Med (2010) 0.98
Transcriptional regulation of neuronal differentiation: the epigenetic layer of complexity. Biochim Biophys Acta (2008) 0.98
MiRNA expression in the eye. Mamm Genome (2008) 0.97
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Developmental microRNA expression profiling of murine embryonic orofacial tissue. Birth Defects Res A Clin Mol Teratol (2010) 0.96
Little but loud: small RNAs have a resounding affect on ear development. Brain Res (2009) 0.94
Palate morphogenesis: current understanding and future directions. Birth Defects Res C Embryo Today (2010) 0.94
The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics (2012) 0.94
MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3. PLoS One (2013) 0.94
Identification of microRNA-like RNAs in mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei. PLoS Negl Trop Dis (2013) 0.93
The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells. Mol Cell Biol (2013) 0.93
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Mol Syst Biol (2009) 0.91
MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. Oncotarget (2015) 0.91
Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes. Front Mol Neurosci (2011) 0.90
Suppression of latent transforming growth factor (TGF)-beta1 restores growth inhibitory TGF-beta signaling through microRNAs. J Biol Chem (2011) 0.90
Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis. Development (2011) 0.90
Differentially expressed wound healing-related microRNAs in the human diabetic cornea. PLoS One (2013) 0.90
Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med (2013) 0.90
Embryonic stem cell-derived microvesicles induce gene expression changes in Müller cells of the retina. PLoS One (2012) 0.90
Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. RNA Biol (2013) 0.89
Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Oncotarget (2013) 0.89
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol Med (2013) 0.89
miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell (2014) 0.88
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J (2014) 0.87
The microRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila. Dev Dyn (2012) 0.86
Characterization of RNA silencing components in the plant pathogenic fungus Fusarium graminearum. Sci Rep (2015) 0.86
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell (2004) 5.69
Making a better RNAi vector for Drosophila: use of intron spacers. Methods (2003) 4.42
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
Silence from within: endogenous siRNAs and miRNAs. Cell (2005) 3.42
Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol (2009) 3.25
The birth and death of microRNA genes in Drosophila. Nat Genet (2008) 3.22
Surface mechanics mediate pattern formation in the developing retina. Nature (2004) 2.84
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev (2002) 2.61
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42
Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina. Proc Natl Acad Sci U S A (2007) 1.92
Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA (2006) 1.85
Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Mol Cell (2013) 1.60
Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nat Struct Mol Biol (2009) 1.42
A call to arms: coevolution of animal viruses and host innate immune responses. Trends Genet (2007) 1.38
Physical modeling of cell geometric order in an epithelial tissue. Proc Natl Acad Sci U S A (2008) 1.34
Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A (2005) 1.30
Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol Cell Biol (2002) 1.20
Biological robustness and the role of microRNAs: a network perspective. Curr Top Dev Biol (2012) 1.14
Expanding roles for miRNAs and siRNAs in cell regulation. Curr Opin Cell Biol (2004) 1.14
Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo. J Cell Sci (2006) 1.02
Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. Development (2008) 1.00
Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors. Proc Natl Acad Sci U S A (2012) 1.00
Functional specialization of the small interfering RNA pathway in response to virus infection. PLoS Pathog (2013) 0.96
Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila. Biochem Biophys Res Commun (2008) 0.95
Molecular biology. Argonaute journeys into the heart of RISC. Science (2004) 0.95
The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics (2012) 0.94
Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye. Mech Dev (2007) 0.86
Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model. PLoS Comput Biol (2011) 0.86
The endo-siRNA pathway is essential for robust development of the Drosophila embryo. PLoS One (2009) 0.85
Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. J Cell Biol (2011) 0.85
A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila. G3 (Bethesda) (2012) 0.83
BMP signaling goes posttranscriptional in a microRNA sort of way. Dev Cell (2008) 0.80
Synthesis of siRNA for RNAi in Drosophila. CSH Protoc (2006) 0.75
Transcript In Situ Hybridization of Whole-Mount Embryos for Phenotype Analysis of RNAi-Treated Drosophila. CSH Protoc (2006) 0.75
Making and breaking with nucleases and small RNAs. Nat Struct Biol (2003) 0.75
Delivery of dsRNA into Drosophila Embryos by Gene Gun. CSH Protoc (2006) 0.75
Microinjection of dsRNA into Drosophila Embryos. CSH Protoc (2006) 0.75
Synthesis of dsRNA for RNAi in Drosophila: PCR Template Method. CSH Protoc (2006) 0.75
Synthesis of dsRNA for RNAi in Drosophila: Plasmid Template Method. CSH Protoc (2006) 0.75
Semiquantitative RT-PCR for Phenotype Analysis of RNAi-Treated Drosophila Embryos. CSH Protoc (2006) 0.75