Published in PLoS Biol on August 01, 2007
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89
MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol (2012) 3.78
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Dev Cell (2014) 2.85
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74
miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes (2008) 2.23
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21
The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology (2008) 2.17
MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res (2009) 2.13
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
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miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA (2007) 1.90
Adult-specific functions of animal microRNAs. Nat Rev Genet (2013) 1.89
Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology (2008) 1.87
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes (2008) 1.85
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes Dev (2009) 1.84
MiR-10 represses HoxB1a and HoxB3a in zebrafish. PLoS One (2008) 1.76
Silencing disease genes in the laboratory and the clinic. J Pathol (2011) 1.72
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
Development of microRNA therapeutics is coming of age. EMBO Mol Med (2014) 1.60
MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol (2010) 1.59
MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications. Diabetes (2011) 1.56
MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res (2012) 1.56
miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol (2011) 1.55
Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One (2010) 1.54
Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun (2007) 1.54
miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol (2011) 1.52
miR-204 is required for lens and retinal development via Meis2 targeting. Proc Natl Acad Sci U S A (2010) 1.48
miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38
Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32
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Advances in microRNAs: implications for immunity and inflammatory diseases. J Cell Mol Med (2009) 1.29
MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci (2010) 1.28
The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS One (2009) 1.25
Regulation of zebrafish fin regeneration by microRNAs. Proc Natl Acad Sci U S A (2008) 1.23
miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos. J Cell Biol (2009) 1.21
Rapid generation of microRNA sponges for microRNA inhibition. PLoS One (2012) 1.17
Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res (2013) 1.14
miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones. Nat Neurosci (2011) 1.14
Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer. PLoS One (2011) 1.12
miR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway. Nucleic Acids Res (2013) 1.11
microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells. Cell Death Dis (2014) 1.09
The emerging use of zebrafish to model metabolic disease. Dis Model Mech (2013) 1.09
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. J Clin Invest (2013) 1.08
Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo. Nat Protoc (2011) 1.07
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression. Pharmaceuticals (Basel) (2013) 1.04
MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection. RNA (2011) 1.02
Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. J Vet Sci (2013) 1.02
Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics (2012) 1.01
Genomic organization of zebrafish microRNAs. BMC Genomics (2008) 1.00
microRNAs: tiny regulators of synapse function in development and disease. J Cell Mol Med (2008) 0.98
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Stem cells as a therapeutic target for diabetes. Front Biosci (Landmark Ed) (2010) 0.96
MicroRNA in teleost fish. Genome Biol Evol (2014) 0.93
MicroRNA signature of the human developing pancreas. BMC Genomics (2010) 0.93
MicroRNA-17~92 is required for nephrogenesis and renal function. J Am Soc Nephrol (2014) 0.93
MicroRNAs as genetic sculptors: fishing for clues. Semin Cell Dev Biol (2010) 0.93
The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development. PLoS One (2013) 0.93
Regulation of microRNA-375 by cAMP in pancreatic β-cells. Mol Endocrinol (2012) 0.92
MicroRNAs in pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2015) 0.90
Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii). BMC Genomics (2014) 0.89
Noncoding RNAs: key molecules in understanding and treating pain. Trends Mol Med (2014) 0.89
MicroRNAs as pharmacological targets in diabetes. Pharmacol Res (2013) 0.88
The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance. Nucleic Acids Res (2014) 0.88
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miR-200s contribute to interleukin-6 (IL-6)-induced insulin resistance in hepatocytes. J Biol Chem (2013) 0.87
Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey. J Biol Chem (2012) 0.86
Identification of conserved and novel microRNAs in cashmere goat skin by deep sequencing. PLoS One (2012) 0.85
Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform. Exp Mol Med (2013) 0.85
Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells. Acta Physiol (Oxf) (2015) 0.84
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Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies. PLoS One (2013) 0.84
Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina. Invest Ophthalmol Vis Sci (2014) 0.83
Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues. Biol Open (2012) 0.83
MicroRNAs and cardiovascular diseases. Biomed Res Int (2015) 0.83
microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells. Stem Cells Dev (2014) 0.82
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CtBP2 downregulation during neural crest specification induces expression of Mitf and REST, resulting in melanocyte differentiation and sympathoadrenal lineage suppression. Mol Cell Biol (2011) 0.81
MicroRNAs as potential targets for progressive pulmonary fibrosis. Front Pharmacol (2015) 0.81
Human Milk Cells and Lipids Conserve Numerous Known and Novel miRNAs, Some of Which Are Differentially Expressed during Lactation. PLoS One (2016) 0.81
Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm (2013) 0.81
Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. Mol Endocrinol (2015) 0.80
Minireview: microRNA function in pancreatic β cells. Mol Endocrinol (2014) 0.80
Role of microRNAs in islet beta-cell compensation and failure during diabetes. J Diabetes Res (2014) 0.80
microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. Oncotarget (2017) 0.79
Structure based approaches for targeting non-coding RNAs with small molecules. Curr Opin Struct Biol (2015) 0.79
Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides. PLoS One (2010) 0.79
MiRNA inhibition in tissue engineering and regenerative medicine. Adv Drug Deliv Rev (2014) 0.79
A Potential of microRNAs for High-Content Screening. J Nucleic Acids (2011) 0.79
Antisense MicroRNA Therapeutics in Cardiovascular Disease: Quo Vadis? Mol Ther (2015) 0.78
Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells. Nucleic Acids Res (2014) 0.78
Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives. Neurosci Bull (2013) 0.78
The Generation of Insulin Producing Cells from Human Mesenchymal Stem Cells by MiR-375 and Anti-MiR-9. PLoS One (2015) 0.78
New model systems to illuminate thyroid organogenesis. Part I: an update on the zebrafish toolbox. Eur Thyroid J (2013) 0.77
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The functions of animal microRNAs. Nature (2004) 64.85
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17
Dicer is essential for mouse development. Nat Genet (2003) 15.87
MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
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The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol (2003) 11.23
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71
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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30
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The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell (2005) 4.54
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Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes Dev (2005) 4.34
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development. Cell (2005) 3.95
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nat Genet (2007) 3.77
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev Biol (2001) 2.04
Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects. Dev Cell (2005) 1.64
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Target-selected gene inactivation in zebrafish. Methods Cell Biol (2004) 1.16
Genetic analysis of early endocrine pancreas formation in zebrafish. Mol Endocrinol (2005) 1.04
Evaluation of developmental phenotypes produced by morpholino antisense targeting of a sea urchin Runx gene. BMC Biol (2004) 0.94
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52
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Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
MicroRNA function in animal development. FEBS Lett (2005) 6.93
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Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66
Secondary siRNAs result from unprimed RNA synthesis and form a distinct class. Science (2006) 5.49
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
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Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature (2003) 4.09
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet (2006) 3.39
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev (2004) 3.21
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell (2009) 3.14
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37
Gene expression: long-term gene silencing by RNAi. Nature (2006) 2.27
Genetic variation in the zebrafish. Genome Res (2006) 2.22
Camels and zebrafish, viruses and cancer: a microRNA update. Hum Mol Genet (2005) 2.18
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Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
The genetics of RNA silencing. Annu Rev Genet (2002) 2.10
Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res (2004) 2.06
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet (2008) 2.03
Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev (2005) 1.94
CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell (2009) 1.94
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr Biol (2003) 1.92
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Science (2002) 1.91
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr Biol (2002) 1.91
Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J (2008) 1.87
Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans. Nat Struct Mol Biol (2007) 1.84
LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition. Diabetes (2007) 1.83
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics (2006) 1.60
Genes required for systemic RNA interference in Caenorhabditis elegans. Curr Biol (2004) 1.59
CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res (2003) 1.57
Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. EMBO J (2004) 1.56
Hen1 is required for oocyte development and piRNA stability in zebrafish. EMBO J (2010) 1.53
RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet (2004) 1.48
Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC Cancer (2009) 1.47
Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy. Biochim Biophys Acta (2010) 1.47
Single nucleotide polymorphisms associated with rat expressed sequences. Genome Res (2004) 1.43
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3. PLoS Genet (2007) 1.41
Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans. EMBO J (2012) 1.41
RDE-1 slicer activity is required only for passenger-strand cleavage during RNAi in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 1.35
Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. Curr Biol (2006) 1.35
Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol (2006) 1.30
Target-selected mutagenesis of the rat. Genomics (2004) 1.26
GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics (2002) 1.25
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc Natl Acad Sci U S A (2004) 1.21
Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. PLoS Genet (2012) 1.20
Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Genome Res (2007) 1.20
The role of small non-coding RNAs in genome stability and chromatin organization. J Cell Sci (2010) 1.19
Target-selected gene inactivation in zebrafish. Methods Cell Biol (2004) 1.16
The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptation. EMBO J (2002) 1.16
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biol (2013) 1.12
Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics (2002) 1.11
RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Nucleic Acids Res (2005) 1.10
Continuous exchange of sequence information between dispersed Tc1 transposons in the Caenorhabditis elegans genome. Genetics (2003) 1.06
MicroRNA-directed siRNA biogenesis in Caenorhabditis elegans. PLoS Genet (2010) 1.05
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04
Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res (2004) 1.01
RNA interference spreading in C. elegans. Methods Enzymol (2005) 0.99
A position-dependent organisation of retinoid response elements is conserved in the vertebrate Hox clusters. Trends Genet (2003) 0.98
Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish. EMBO J (2011) 0.95
Generation and characterization of FMR1 knockout zebrafish. PLoS One (2009) 0.93
Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development (2011) 0.93
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics (2005) 0.92
Proteins interacting with Caenorhabditis elegans Galpha subunits. Comp Funct Genomics (2003) 0.91
Profiling of RNA modifications by multiplexed stable isotope labelling. Chem Commun (Camb) (2014) 0.91
Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol (2003) 0.89
Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics (2003) 0.89
Isolation of RNA from C. elegans. CSH Protoc (2006) 0.88
Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans. Genetics (2002) 0.88
Mutations in LRRC50 predispose zebrafish and humans to seminomas. PLoS Genet (2013) 0.87