Published in Curr Biol on January 24, 2006
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med (2007) 3.48
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res (2012) 3.02
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol (2007) 2.29
Biological roles for the NOX family NADPH oxidases. J Biol Chem (2008) 1.96
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med (2006) 1.76
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal (2009) 1.71
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med (2011) 1.56
In vivo cell wall loosening by hydroxyl radicals during cress seed germination and elongation growth. Plant Physiol (2009) 1.49
Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice. J Clin Invest (2008) 1.49
NOX and inflammation in the vascular adventitia. Free Radic Biol Med (2009) 1.37
A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet (2009) 1.29
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix. Dev Biol (2007) 1.19
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J (2007) 1.17
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol (2007) 1.17
Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1. PLoS One (2010) 1.15
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res (2006) 1.12
NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol (2014) 1.08
NADPH oxidases: molecular understanding finally reaching the clinical level? Antioxid Redox Signal (2009) 0.93
In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure. Hear Res (2010) 0.86
Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn (2010) 0.83
Absence of cytoglobin promotes multiple organ abnormalities in aged mice. Sci Rep (2016) 0.82
Molecular characterization of an allelic series of mutations in the mouse Nox3 gene. Mamm Genome (2010) 0.81
Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxid Redox Signal (2015) 0.79
Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol (2014) 0.77
A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase. Sci Rep (2016) 0.77
Mechanisms of otoconia and otolith development. Dev Dyn (2014) 0.77
The Importance of NADPH Oxidases and Redox Signaling in Angiogenesis. Antioxidants (Basel) (2017) 0.76
Discovery Genetics - The History and Future of Spontaneous Mutation Research. Curr Protoc Mouse Biol (2012) 0.76
Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis (2010) 0.76
Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice. Mamm Genome (2015) 0.76
A Chromosome 17 Locus Engenders Frequency-Specific Non-Progressive Hearing Loss that Contributes to Age-Related Hearing Loss in Mice. J Assoc Res Otolaryngol (2015) 0.75
Molecular cloning and functional characterization of the dual oxidase (BmDuox) gene from the silkworm Bombyx mori. PLoS One (2013) 0.75
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing. Proc Natl Acad Sci U S A (2010) 3.85
Forty-six genes causing nonsyndromic hearing impairment: which ones should be analyzed in DNA diagnostics? Mutat Res (2008) 3.76
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol (2005) 3.57
Glomeruli of Dense Deposit Disease contain components of the alternative and terminal complement pathway. Kidney Int (2009) 3.12
C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up. Kidney Int (2012) 3.05
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Eculizumab for dense deposit disease and C3 glomerulonephritis. Clin J Am Soc Nephrol (2012) 2.83
GJB2 mutations and degree of hearing loss: a multicenter study. Am J Hum Genet (2005) 2.63
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion. Kidney Int (2011) 2.61
Bringing the ocean into the laboratory to probe the chemical complexity of sea spray aerosol. Proc Natl Acad Sci U S A (2013) 2.46
Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Hum Mutat (2010) 2.44
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab (2010) 2.26
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation (2004) 2.25
Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system. Endocrinology (2003) 2.21
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab (2008) 2.17
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Hum Mol Genet (2005) 2.04
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metab (2012) 1.99
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Proliferative glomerulonephritis secondary to dysfunction of the alternative pathway of complement. Clin J Am Soc Nephrol (2011) 1.92
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci (2007) 1.90
Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol (2007) 1.87
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement. Kidney Int (2012) 1.81
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res (2002) 1.81
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res (2002) 1.81
Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet (2003) 1.80
Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study. Am J Hum Genet (2003) 1.79
Branchio-oto-renal syndrome: the mutation spectrum in EYA1 and its phenotypic consequences. Hum Mutat (2004) 1.77
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A (2004) 1.77
Evidence supporting a functional role for intracellular renin in the brain. Hypertension (2006) 1.76
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest (2004) 1.74
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res (2009) 1.71
Causes of alternative pathway dysregulation in dense deposit disease. Clin J Am Soc Nephrol (2012) 1.70
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am J Physiol Renal Physiol (2004) 1.69
Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension (2009) 1.68
Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. Hum Mutat (2003) 1.67
Advancing genetic testing for deafness with genomic technology. J Med Genet (2013) 1.66
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet (2008) 1.65
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A (2002) 1.65
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res (2002) 1.64
PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension (2004) 1.64
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes (2008) 1.60
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol (2008) 1.60
The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol (2010) 1.60
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59
Transcriptional control of SLC26A4 is involved in Pendred syndrome and nonsyndromic enlargement of vestibular aqueduct (DFNB4). Am J Hum Genet (2007) 1.59
An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda) (2008) 1.59
Dense deposit disease associated with monoclonal gammopathy of undetermined significance. Am J Kidney Dis (2010) 1.57
Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest (2007) 1.56
Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol (2013) 1.56
Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing children. Genet Med (2010) 1.56
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension (2008) 1.55
Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet (2007) 1.52
New treatment options for lymphangioma in infants and children. Ann Otol Rhinol Laryngol (2002) 1.50
Audioprofile-directed screening identifies novel mutations in KCNQ4 causing hearing loss at the DFNA2 locus. Genet Med (2008) 1.49
Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice. J Clin Invest (2008) 1.49
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res (2008) 1.48
Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro. Environ Health Perspect (2013) 1.47
Genetic basis of hypertension: revisiting angiotensinogen. Hypertension (2006) 1.46
Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiol Genomics (2004) 1.44
Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy. Clin J Am Soc Nephrol (2010) 1.42
Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol (2005) 1.41
No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Otol Neurotol (2009) 1.40
Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension (2003) 1.40
Function and expression pattern of nonsyndromic deafness genes. Curr Mol Med (2009) 1.40
Allelic variants of complement genes associated with dense deposit disease. J Am Soc Nephrol (2011) 1.38
Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus. Hum Mutat (2007) 1.37
Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus. Am J Hum Genet (2002) 1.37
Deafness in the genomics era. Hear Res (2011) 1.37
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet (2009) 1.37
Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42. Am J Hum Genet (2011) 1.37
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 1.37
Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. J Med Genet (2006) 1.36
Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR. Hum Mutat (2008) 1.35
Branchio-oto-renal syndrome. Am J Med Genet A (2007) 1.34
Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat Commun (2011) 1.33
Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2013) 1.32
Pendred syndrome and DFNB4-mutation screening of SLC26A4 by denaturing high-performance liquid chromatography and the identification of eleven novel mutations. Am J Med Genet A (2004) 1.32
Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J Biol Chem (2002) 1.30
A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet (2009) 1.29
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res (2011) 1.27
Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J Biol Chem (2011) 1.25
Advances in molecular and cellular therapies for hearing loss. Mol Ther (2007) 1.25
Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics (2006) 1.25
Genotype-phenotype correlations for SLC26A4-related deafness. Hum Genet (2007) 1.24
C3 glomerulonephritis associated with monoclonal gammopathy: a case series. Am J Kidney Dis (2013) 1.24