Published in J Am Soc Nephrol on January 07, 2010
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int (2010) 1.54
microRNAs in kidneys: biogenesis, regulation, and pathophysiological roles. Am J Physiol Renal Physiol (2011) 1.50
Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int (2015) 1.47
The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis. J Biol Chem (2012) 1.34
Development of the renal arterioles. J Am Soc Nephrol (2011) 1.32
The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol (2011) 1.27
Genetics of congenital anomalies of the kidney and urinary tract. Pediatr Nephrol (2010) 1.25
Transcriptional regulator RBP-J regulates the number and plasticity of renin cells. Physiol Genomics (2011) 1.16
MicroRNAs regulate renal tubule maturation through modulation of Pkd1. J Am Soc Nephrol (2012) 1.12
Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. J Am Soc Nephrol (2013) 1.12
Recent advances involving the renin-angiotensin system. Exp Cell Res (2012) 1.09
MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1. Nucleic Acids Res (2012) 1.01
RBP-J in FOXD1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells. Am J Physiol Renal Physiol (2013) 1.01
Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype. Am J Physiol Renal Physiol (2011) 1.00
Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes. J Diabetes Investig (2014) 0.98
MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol (2015) 0.98
Local renal circadian clocks control fluid-electrolyte homeostasis and BP. J Am Soc Nephrol (2014) 0.97
Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol (2014) 0.97
Renal nerves drive interstitial fibrogenesis in obstructive nephropathy. J Am Soc Nephrol (2012) 0.96
MicroRNAs in kidney function and disease. Transl Res (2011) 0.96
Pericytes synthesize renin. World J Nephrol (2013) 0.94
MicroRNA-17~92 is required for nephrogenesis and renal function. J Am Soc Nephrol (2014) 0.93
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The mitochondrial genome encodes abundant small noncoding RNAs. Cell Res (2013) 0.92
Classical Renin-Angiotensin system in kidney physiology. Compr Physiol (2014) 0.92
Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes. PLoS One (2013) 0.90
The long and short of microRNAs in the kidney. J Am Soc Nephrol (2012) 0.89
MicroRNA in diabetic nephropathy: renin angiotensin, aGE/RAGE, and oxidative stress pathway. J Diabetes Res (2013) 0.88
Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension. Curr Hypertens Rep (2011) 0.87
The renin phenotype: roles and regulation in the kidney. Curr Opin Nephrol Hypertens (2010) 0.87
Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression. J Am Soc Nephrol (2014) 0.87
The regulation and function of microRNAs in kidney diseases. IUBMB Life (2013) 0.87
MicroRNAs and their applications in kidney diseases. Pediatr Nephrol (2014) 0.84
Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. PLoS One (2013) 0.83
MicroRNAs in renal development. Pediatr Nephrol (2012) 0.83
Regulation of renin secretion by renal juxtaglomerular cells. Pflugers Arch (2012) 0.83
MicroRNA regulation in renal pathophysiology. Int J Mol Sci (2013) 0.82
MicroRNA-489 Induction by Hypoxia-Inducible Factor-1 Protects against Ischemic Kidney Injury. J Am Soc Nephrol (2016) 0.80
Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease. PLoS One (2015) 0.80
Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. J Pathol (2015) 0.79
MicroRNAs in the pathogenesis of cystic kidney disease. Curr Opin Pediatr (2015) 0.79
Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion-induced injury. Sci Rep (2016) 0.78
MicroRNAs: potential regulators of renal development genes that contribute to CAKUT. Pediatr Nephrol (2013) 0.78
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep (2015) 0.77
miRNAs in mammalian ureteric bud development. Pediatr Nephrol (2014) 0.77
Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling. Am J Physiol Regul Integr Comp Physiol (2015) 0.76
Essential hypertension: perspectives and future directions. J Hypertens (2012) 0.76
Epigenetic bystander-like effects of stroke in somatic organs. Aging (Albany NY) (2012) 0.76
A MicroRNA Cluster miR-23-24-27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport. J Cell Physiol (2017) 0.75
Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis. Physiol Rep (2015) 0.75
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. Kidney Int (2016) 0.75
Deletion of the miR-143/145 cluster leads to hydronephrosis in mice. Am J Pathol (2014) 0.75
MicroRNAs in the Pathobiology and Therapy of Atherosclerosis. Can J Cardiol (2017) 0.75
Renal dysplasia in the neonate. Curr Opin Pediatr (2016) 0.75
Are microRNAs the key to transforming renin progenitor cells in the afferent renal circulation? Am J Physiol Renal Physiol (2011) 0.75
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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol (2008) 7.27
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 5.26
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension (2001) 4.41
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
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Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell (2004) 2.52
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
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Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype. Am J Physiol Regul Integr Comp Physiol (2003) 1.83
MicroRNAs and cell differentiation in mammalian development. Birth Defects Res C Embryo Today (2006) 1.78
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Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem (2001) 1.72
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol (2004) 1.71
Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs. Cell Cycle (2008) 1.50
CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. Am J Physiol Heart Circ Physiol (2009) 1.47
Identity of the renin cell is mediated by cAMP and chromatin remodeling: an in vitro model for studying cell recruitment and plasticity. Am J Physiol Heart Circ Physiol (2007) 1.39
Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem (2000) 1.38
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiol Genomics (2001) 1.19
Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem (1999) 1.16
Renin-expressing cells are associated with branching of the developing kidney vasculature. J Am Soc Nephrol (1998) 1.09
Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme. Hypertension (1997) 1.03
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. Kidney Int (2002) 0.91
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MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet (2006) 3.79
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell (2004) 2.52
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab (2010) 2.26
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation (2004) 2.25
Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system. Endocrinology (2003) 2.21
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab (2008) 2.17
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Hum Mol Genet (2005) 2.04
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metab (2012) 1.99
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn (2008) 1.91
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem (2009) 1.89
Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol (2007) 1.87
Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells. Am J Physiol Renal Physiol (2006) 1.86
Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype. Am J Physiol Regul Integr Comp Physiol (2003) 1.83
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res (2002) 1.81
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res (2002) 1.81
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A (2004) 1.77
Evidence supporting a functional role for intracellular renin in the brain. Hypertension (2006) 1.76
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest (2004) 1.74
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res (2009) 1.71
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol (2004) 1.71
Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech (2010) 1.69
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am J Physiol Renal Physiol (2004) 1.69
Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension (2009) 1.68
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res (2002) 1.64
PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension (2004) 1.64
Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension (2006) 1.62
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes (2008) 1.60
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol (2008) 1.60
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59
An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda) (2008) 1.59
Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest (2007) 1.56
Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol (2013) 1.56
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension (2008) 1.55
Dicer1 is required for differentiation of the mouse male germline. Biol Reprod (2008) 1.52
Genes that confer the identity of the renin cell. J Am Soc Nephrol (2011) 1.52
Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum. Dev Biol (2008) 1.51
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron (2012) 1.50
Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.49
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res (2008) 1.48
A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev Cell (2003) 1.48
Genetic basis of hypertension: revisiting angiotensinogen. Hypertension (2006) 1.46
Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiol Genomics (2004) 1.44
Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension (2003) 1.40
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40
Identity of the renin cell is mediated by cAMP and chromatin remodeling: an in vitro model for studying cell recruitment and plasticity. Am J Physiol Heart Circ Physiol (2007) 1.39
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 1.37
Development of the renal arterioles. J Am Soc Nephrol (2011) 1.32
Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 1.32
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31
Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn (2008) 1.30
Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J Biol Chem (2002) 1.30
Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. FASEB J (2004) 1.28
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (2005) 1.27
Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol (2006) 1.27
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res (2011) 1.27
Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development (2009) 1.23
Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. Am J Physiol Endocrinol Metab (2004) 1.23
Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiol Genomics (2008) 1.22
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol (2009) 1.21
BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am (2008) 1.20
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res (2002) 1.20
Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circ Res (2006) 1.20
Cerebral vascular effects of angiotensin II: new insights from genetic models. J Cereb Blood Flow Metab (2006) 1.19
Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology (2006) 1.17
Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol Genomics (2004) 1.17
Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity (2004) 1.17
Transcriptional regulator RBP-J regulates the number and plasticity of renin cells. Physiol Genomics (2011) 1.16