Published in Cell on March 22, 2002
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Protein factors in pre-mRNA 3'-end processing. Cell Mol Life Sci (2008) 3.44
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature (2006) 2.95
Formation and repair of interstrand cross-links in DNA. Chem Rev (2006) 2.91
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res (2002) 2.76
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol (2003) 2.74
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J (2002) 2.62
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A (2011) 2.47
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol (2005) 2.37
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A (2006) 2.17
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. RNA (2004) 2.10
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci U S A (2007) 2.09
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
Formation of the 3' end of histone mRNA: getting closer to the end. Gene (2007) 2.07
Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Res (2006) 2.02
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature (2009) 1.97
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
DNA repair mechanisms in dividing and non-dividing cells. DNA Repair (Amst) (2013) 1.85
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
DNA interstrand crosslink repair in mammalian cells: step by step. Crit Rev Biochem Mol Biol (2010) 1.82
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res (2004) 1.77
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A (2007) 1.69
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res (2004) 1.67
A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100. Mol Cell Biol (2005) 1.65
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol (2007) 1.65
Recent reports on the effect of low doses of ionizing radiation and its dose-effect relationship. Radiat Environ Biophys (2006) 1.65
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair. Hum Mutat (2009) 1.64
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest (2005) 1.59
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). Nucleic Acids Res (2005) 1.56
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res (2007) 1.56
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. EMBO J (2004) 1.54
B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med (2004) 1.53
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Rejoining of DNA double-strand breaks as a function of overhang length. Mol Cell Biol (2005) 1.52
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A (2003) 1.47
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev (2011) 1.46
Hsp90: A New Player in DNA Repair? Biomolecules (2015) 1.45
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med (2008) 1.44
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J (2012) 1.44
Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks. Nucleic Acids Res (2008) 1.40
Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J (2005) 1.38
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Mol Cell Biol (2003) 1.37
Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J Clin Invest (2003) 1.36
Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Res (2008) 1.36
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining. DNA Repair (Amst) (2008) 1.35
New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci Transl Med (2013) 1.35
The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice. J Virol (2007) 1.35
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther (2010) 1.34
Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics (2006) 1.33
DNA double-strand break repair pathway choice and cancer. DNA Repair (Amst) (2014) 1.33
Alternative pathways for the repair of RAG-induced DNA breaks. Mol Cell Biol (2006) 1.32
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol (2004) 1.31
A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics (2004) 1.28
Abundance and length of simple repeats in vertebrate genomes are determined by their structural properties. Genome Res (2008) 1.25
Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) (2014) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase. Nucleic Acids Res (2009) 1.24
Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism. Mol Cell Biol (2003) 1.21
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism. RNA (2010) 1.20
Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining. Mol Cell Biol (2005) 1.18
Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair. Proc Natl Acad Sci U S A (2015) 1.17
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U S A (2011) 1.17
Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining. Mol Cancer Res (2005) 1.16
The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination. J Exp Med (2004) 1.16
DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med (2007) 1.16
Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.16
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase. Mol Cell Biol (2005) 1.14
A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics (2002) 1.14
Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans. Subcell Biochem (2010) 1.13
A biochemically defined system for coding joint formation in V(D)J recombination. Mol Cell (2008) 1.13
Differential activation of DNA-PK based on DNA strand orientation and sequence bias. Nucleic Acids Res (2005) 1.12
Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics (2008) 1.12
Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol (2003) 6.49
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol (2003) 4.81
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity (2010) 3.59
Bidirectional gene organization: a common architectural feature of the human genome. Cell (2002) 3.47
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell (2008) 3.31
A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell (2004) 3.01
A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature (2004) 2.92
The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A (2002) 2.82
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. Mol Cell (2009) 2.40
Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol (2002) 2.27
DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J Biol Chem (2003) 2.16
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet (2009) 2.12
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications. Mol Ther (2010) 1.95
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) (2004) 1.93
Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics (2003) 1.91
Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci U S A (2009) 1.91
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem (2005) 1.84
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis. Haematologica (2005) 1.83
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst) (2005) 1.81
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80
An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med (2008) 1.71
SCID patients with ARTEMIS vs RAG deficiencies following HCT: increased risk of late toxicity in ARTEMIS-deficient SCID. Blood (2013) 1.68
Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity. J Biol Chem (2007) 1.65
Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet (2011) 1.63
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res (2007) 1.56
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. EMBO J (2004) 1.54
A variant of SCID with specific immune responses and predominance of gamma delta T cells. J Clin Invest (2005) 1.54
Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol (2007) 1.54
Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst) (2003) 1.51
Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol (2007) 1.48
Omenn syndrome due to ARTEMIS mutations. Blood (2005) 1.47
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol (2006) 1.45
G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter. Mol Cell Biol (2009) 1.43
Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol (2010) 1.43
Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II. Blood (2006) 1.42
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) (2002) 1.41
Results of intracoronary stem cell therapy after acute myocardial infarction. Am J Cardiol (2010) 1.40
Clinical and immunological manifestations of patients with atypical severe combined immunodeficiency. Clin Immunol (2011) 1.38
Mechanisms of chromosomal rearrangement in the human genome. BMC Genomics (2010) 1.37
Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med (2013) 1.37
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35
Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus. J Gene Med (2006) 1.35
Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A (2006) 1.35
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nat Genet (2008) 1.34
Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol (2011) 1.32
Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol (2005) 1.32
A severe form of human combined immunodeficiency due to mutations in DNA ligase IV. J Immunol (2006) 1.31
High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis. Blood (2013) 1.30
Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res (2010) 1.30
Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia. J Biol Chem (2002) 1.29
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells. Cancer Res (2007) 1.29
Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model. Cell Cycle (2005) 1.28
DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem (2006) 1.28
Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro. Mol Cell Biol (2005) 1.27
Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem (2005) 1.27
Generation and characterization of endonuclease G null mice. Mol Cell Biol (2005) 1.25
Genetic interactions between BLM and DNA ligase IV in human cells. J Biol Chem (2004) 1.25
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break. Mol Ther (2006) 1.16
A novel single point mutation of the LYST gene in two siblings with different phenotypic features of Chediak Higashi syndrome. Pediatr Blood Cancer (2011) 1.16
Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation. Blood (2005) 1.16
Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases. Haematologica (2010) 1.15
DNA structures at chromosomal translocation sites. Bioessays (2006) 1.14
A biochemically defined system for coding joint formation in V(D)J recombination. Mol Cell (2008) 1.13
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol (2013) 1.12
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood (2011) 1.12
NHEJ and its backup pathways in chromosomal translocations. Nat Struct Mol Biol (2010) 1.11
Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13). Genome Res (2008) 1.10
Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem (2008) 1.10
DNA damage and aging. Mech Ageing Dev (2004) 1.09
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst) (2010) 1.07