Published in Nat Neurosci on March 05, 2006
TRP channels. Annu Rev Biochem (2007) 8.09
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A (2007) 2.02
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron (2008) 1.79
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
Monoterpenoid agonists of TRPV3. Br J Pharmacol (2007) 1.50
Regulation of TRP channels by PIP(2). Pflugers Arch (2006) 1.37
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci U S A (2009) 1.33
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol (2007) 1.16
Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol (2008) 1.12
Ligand stoichiometry of the cold- and menthol-activated channel TRPM8. J Physiol (2011) 1.10
Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function. Cell Rep (2013) 1.07
Transient receptor potential (TRP) channels in the airway: role in airway disease. Br J Pharmacol (2014) 1.05
Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron (2014) 1.05
Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One (2008) 1.01
Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol (2008) 0.99
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem (2012) 0.97
Molecular and cellular mechanisms of trigeminal chemosensation. Ann N Y Acad Sci (2009) 0.96
Chemical activation of the mechanotransduction channel Piezo1. Elife (2015) 0.96
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nat Commun (2016) 0.95
Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. Am J Physiol Lung Cell Mol Physiol (2008) 0.95
TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A (2013) 0.94
Regulation of TRPM8 channel activity. Mol Cell Endocrinol (2011) 0.94
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A (2011) 0.93
The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr Neuropharmacol (2006) 0.93
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J (2010) 0.93
A structural view of ligand-dependent activation in thermoTRP channels. Front Physiol (2014) 0.92
Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol (2008) 0.92
High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites. Front Mol Neurosci (2009) 0.92
The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8. J Biol Chem (2014) 0.91
Exploring structure-function relationships between TRP and Kv channels. Sci Rep (2013) 0.90
Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. Alcohol Clin Exp Res (2014) 0.89
Modulation of thermoreceptor TRPM8 by cooling compounds. ACS Chem Neurosci (2012) 0.88
ThermoTRPs and Pain. Neuroscientist (2015) 0.86
High throughput screening technologies for ion channels. Acta Pharmacol Sin (2015) 0.86
Pharmacology of transient receptor potential melastatin channels in the vasculature. Br J Pharmacol (2010) 0.85
Concentration-detection functions for eye irritation evoked by homologous n-alcohols and acetates approaching a cut-off point. Exp Brain Res (2007) 0.84
The use of yeast to understand TRP-channel mechanosensitivity. Pflugers Arch (2009) 0.84
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. Mol Pain (2009) 0.84
Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Mol Biosyst (2009) 0.83
Mechanical force and cytoplasmic Ca(2+) activate yeast TRPY1 in parallel. J Membr Biol (2009) 0.82
Comparative sequence analysis suggests a conserved gating mechanism for TRP channels. J Gen Physiol (2015) 0.81
The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res (2013) 0.81
Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. J Physiol Sci (2015) 0.79
The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. J Biol Chem (2014) 0.79
Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2. PLoS One (2012) 0.79
Surface expression and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4. Pflugers Arch (2013) 0.79
Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation. PLoS One (2014) 0.79
Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem (2014) 0.79
Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealed by intrinsic tryptophan fluorescence quenching. J Biol Chem (2015) 0.78
A mint of mutations in TRPM8 leads to cool results. Nat Neurosci (2006) 0.78
Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain. J Biol Chem (2014) 0.78
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity. J Biol Chem (2014) 0.78
Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion. Cancers (Basel) (2015) 0.77
The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. PLoS One (2014) 0.77
The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem (2011) 0.77
Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep (2015) 0.77
Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Biosci Rep (2014) 0.77
Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel. Biophys J (2015) 0.77
Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry (2015) 0.77
Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution. PeerJ (2015) 0.77
Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents. J Agric Food Chem (2016) 0.76
Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function. Int J Biol Sci (2017) 0.75
Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein. J Biol Chem (2014) 0.75
4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities. Sci Rep (2017) 0.75
Cool channel subunits reveal their independent interactions with menthol. J Physiol (2011) 0.75
Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties. Physiol Rep (2017) 0.75
Definition of two agonist types at the mammalian cold-activated channel TRPM8. Elife (2016) 0.75
Evidence for the functional involvement of members of the TRP channel family in the uptake of Na(+) and NH4 (+) by the ruminal epithelium. Pflugers Arch (2016) 0.75
TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity. Sci Rep (2017) 0.75
Cellular and Molecular Targets of Menthol Actions. Front Pharmacol (2017) 0.75
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29
Human host factors required for influenza virus replication. Nature (2010) 5.28
TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25
Trp ion channels and temperature sensation. Annu Rev Neurosci (2006) 4.35
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53
A probability-based approach for the analysis of large-scale RNAi screens. Nat Methods (2007) 3.34
Opposite thermosensor in fruitfly and mouse. Nature (2003) 3.04
An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
The role of Drosophila Piezo in mechanical nociception. Nature (2012) 2.72
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem (2006) 2.65
Bacteria activate sensory neurons that modulate pain and inflammation. Nature (2013) 2.56
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19
More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci (2006) 2.17
Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med (2006) 2.01
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2002) 1.94
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron (2009) 1.93
Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J Neurosci (2008) 1.92
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci (2010) 1.92
Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci (2003) 1.88
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci (2005) 1.83
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem (2003) 1.68
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nat Commun (2013) 1.60
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry (2006) 1.51
Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci U S A (2013) 1.34
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci U S A (2009) 1.33
Inflammatory signals enhance piezo2-mediated mechanosensitive currents. Cell Rep (2012) 1.32
Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci (2006) 1.32
TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS One (2009) 1.30
LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. J Biol Chem (2006) 1.28
Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci (2007) 1.26
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem (2005) 1.20
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J Biol Chem (2010) 1.17
Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett (2007) 1.15
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem (2002) 1.14
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci (2004) 1.07
A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proc Natl Acad Sci U S A (2009) 1.04
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat Commun (2011) 1.03
Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1. Bioorg Med Chem Lett (2007) 1.01
Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol (2009) 0.98
N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett (2008) 0.98
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain (2011) 0.97