Published in Front Physiol on May 05, 2014
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nat Chem Biol (2015) 1.11
Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin. Proc Natl Acad Sci U S A (2015) 0.89
Phosphoinositide regulation of TRPV1 revisited. Pflugers Arch (2015) 0.84
TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy. Cells (2014) 0.83
A transient receptor potential ion channel in Chlamydomonas shares key features with sensory transduction-associated TRP channels in mammals. Plant Cell (2015) 0.81
Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem (2014) 0.79
The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. Biophys J (2015) 0.79
Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains. Sci Rep (2016) 0.78
Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels. Curr Neuropharmacol (2015) 0.76
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A TRP conductance modulates repolarization after sensory-dependent depolarization in Chlamydomonas reinhardtii. Plant Signal Behav (2015) 0.75
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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol (2005) 4.48
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci (2005) 4.00
TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53
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Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A (2007) 2.02
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The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Monoterpenoid agonists of TRPV3. Br J Pharmacol (2007) 1.50
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Localization of the PIP2 sensor of TRPV1 ion channels. J Biol Chem (2011) 1.38
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Structural determinants of gating in the TRPV1 channel. Nat Struct Mol Biol (2009) 1.33
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J (2011) 1.33
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Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. J Physiol (2006) 1.25
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther (2008) 1.25
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Regulation of voltage-gated potassium channels by PI(4,5)P2. J Gen Physiol (2012) 1.22
The TRPV1 receptor and nociception. Semin Cell Dev Biol (2006) 1.21
Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A (2011) 1.19
Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line. Eur J Biochem (2001) 1.19
Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel. J Biol Chem (2007) 1.16
Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol (2008) 1.15
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1. J Biol Chem (2004) 1.13
A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J Neurosci (2007) 1.13
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J (2008) 1.12
Molecular modeling of the full-length human TRPV1 channel in closed and desensitized states. J Membr Biol (2008) 1.11
Analgesic potential of TRPV1 antagonists. Biochem Pharmacol (2009) 1.08
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Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region". J Med Chem (1993) 1.06
Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. J Biol Chem (2013) 1.06
FRET-based analysis of TRPC subunit stoichiometry. Cell Calcium (2003) 1.06
Thymol and related alkyl phenols activate the hTRPA1 channel. Br J Pharmacol (2008) 1.04
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J Med Chem (2005) 1.02
Near-membrane dynamics and capture of TRPM8 channels within transient confinement domains. PLoS One (2010) 1.02
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Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data. Mol Pain (2013) 1.01
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Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis. J Gen Physiol (2011) 0.99
Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol (2008) 0.99
TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One (2012) 0.99
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A (2013) 0.99
Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate. J Neurosci (2013) 0.99
Activation of TRPA1 by farnesyl thiosalicylic acid. Mol Pharmacol (2008) 0.98
N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett (2008) 0.98
TRP channels and thermosensation. Chem Senses (2005) 0.98
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Lipid modulation of ion channels through specific binding sites. Biochim Biophys Acta (2013) 0.94
TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A (2013) 0.94
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci (2010) 0.93
Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding features. Biochim Biophys Acta (2009) 0.92