Published in J Neurosci on January 16, 2008
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
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Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
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Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS One (2011) 1.34
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Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol (2009) 1.09
Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats. Behav Brain Res (2010) 1.08
Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors. J Neurosci (2008) 1.07
Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol (2011) 1.06
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TRPM8 mechanism of autonomic nerve response to cold in respiratory airway. Mol Pain (2008) 0.86
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Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
Quantitative characterization reveals three types of dry-sensitive corneal afferents: pattern of discharge, receptive field, and thermal and chemical sensitivity. J Neurophysiol (2012) 0.83
TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol (2014) 0.82
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Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. Chem Senses (2011) 0.81
Effect of capsaicin on thermoregulation: an update with new aspects. Temperature (Austin) (2015) 0.81
Axonal protein synthesis and the regulation of primary afferent function. Dev Neurobiol (2013) 0.80
Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Neuroscience (2009) 0.80
Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats. J Pain (2009) 0.80
TRPs in taste and chemesthesis. Handb Exp Pharmacol (2014) 0.80
Neural circuits underlying thirst and fluid homeostasis. Nat Rev Neurosci (2017) 0.79
A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies. Commun Integr Biol (2009) 0.79
Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation. PLoS One (2014) 0.79
TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons. Mol Neurodegener (2011) 0.79
Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons. Neuroscience (2012) 0.79
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. Pain (2014) 0.79
Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation. Brain Behav (2012) 0.78
Central connectivity of transient receptor potential melastatin 8-expressing axons in the brain stem and spinal dorsal horn. PLoS One (2014) 0.78
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Selective innervation of NK1 receptor-lacking lamina I spinoparabrachial neurons by presumed nonpeptidergic Aδ nociceptors in the rat. Pain (2014) 0.78
Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache. Cephalalgia (2015) 0.78
Non-peptidergic small diameter primary afferents expressing VGluT2 project to lamina I of mouse spinal dorsal horn. Mol Pain (2011) 0.77
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AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.77
Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. Mol Pain (2015) 0.76
Sustained morphine administration induces TRPM8 dependent cold hyperalgesia. J Pain (2016) 0.75
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Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse. Neuroscience (2015) 0.75
Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons. J Physiol (2014) 0.75
Mechanisms and time course of menthol-induced cutaneous vasodilation. Microvasc Res (2016) 0.75
Temperature receptors in cutaneous nerve endings are thermostat molecules that induce thermoregulatory behaviors against thermal load. Temperature (Austin) (2015) 0.75
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Cannabinoid 1 receptor knockout mice display cold allodynia, but enhanced recovery from spared-nerve injury-induced mechanical hypersensitivity. Mol Pain (2016) 0.75
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TRPM8 and Migraine. Headache (2016) 0.75
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Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons. Chem Senses (2016) 0.75
Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8. Temperature (Austin) (2015) 0.75
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Receptive field size, chemical and thermal responses, and fiber conduction velocity of rat chorda tympani geniculate ganglion neurons. J Neurophysiol (2016) 0.75
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Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing. PLoS One (2017) 0.75
Menthol evokes Ca(2+) signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells. Redox Biol (2017) 0.75
Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments. Int J Mol Sci (2017) 0.75
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ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29
TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25
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The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
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Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53
Opposite thermosensor in fruitfly and mouse. Nature (2003) 3.04
An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
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Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19
More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci (2006) 2.17
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Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
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Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron (2009) 1.93
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
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TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37
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