Published in Proc Natl Acad Sci U S A on July 10, 2008
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
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Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet (2011) 5.67
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β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
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Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions. J Clin Invest (2012) 0.92
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A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. Cell Cycle (2015) 0.87
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Integrated analysis of the Wnt responsive proteome in human cells reveals diverse and cell-type specific networks. Mol Biosyst (2014) 0.80
Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions. Cancer Res (2014) 0.80
A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators. Mol Cancer (2015) 0.80
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2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications. Oncotarget (2017) 0.77
The Role of the C-Clamp in Wnt-Related Colorectal Cancers. Cancers (Basel) (2016) 0.77
Regulation of alternative splicing in obesity and weight loss. Adipocyte (2013) 0.76
Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells. PLoS One (2015) 0.76
Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts. Methods Mol Biol (2015) 0.76
Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals. Proc Natl Acad Sci U S A (2016) 0.75
Association of transcription factor 7-like 2 gene polymorphisms with breast cancer risk in northwest Chinese women. Oncotarget (2016) 0.75
Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. BMC Med Genomics (2014) 0.75
Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep (2016) 0.75
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife (2016) 0.75
A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy. Cell Res (2016) 0.75
Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study. Nutrients (2017) 0.75
Insights to transcriptional networks by using high throughput RNAi strategies. Brief Funct Genomics (2009) 0.75
TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Sci Rep (2016) 0.75
The Wnt/β-catenin signaling pathway mechanism for pancreatic cancer chemoresistance in a three-dimensional cancer microenvironment. Am J Transl Res (2016) 0.75
A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis. Sci Rep (2017) 0.75
RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation. Int J Mol Sci (2017) 0.75
Defining the cancer master switch. World J Surg (2011) 0.75
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science (2007) 8.07
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet (2001) 5.09
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
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Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem (2006) 2.51
Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett (2006) 2.12
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. Proc Natl Acad Sci U S A (2002) 1.94
A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol (2007) 1.70
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene (2006) 1.56
Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev (2004) 1.53
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene (2006) 1.35
A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer. Oncol Rep (2006) 1.06
Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. Oncogene (1999) 0.97
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38
Targeting QseC signaling and virulence for antibiotic development. Science (2008) 3.26
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell (2006) 2.92
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (2011) 1.92
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol (2013) 1.64
Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol (2003) 1.57
Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A (2003) 1.55
Single and multiple viral infections in lower respiratory tract infection. Respiration (2010) 1.50
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal (2011) 1.45
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev Biol (2012) 1.43
Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease. Respiration (2015) 1.39
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem (2012) 1.33
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem (2003) 1.32
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nat Immunol (2013) 1.28
Asthma: is it due to an abnormal airway smooth muscle cell? Am J Respir Crit Care Med (2006) 1.27
Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J Allergy Clin Immunol (2004) 1.27
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Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett (2009) 1.24
The effect of short-term withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea. J Sleep Res (2007) 1.19
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell (2012) 1.19
Deconstructing the hedgehog pathway in development and disease. Science (2007) 1.18
Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma. J Cell Physiol (2008) 1.18
Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. Proc Natl Acad Sci U S A (2011) 1.16
Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax (2007) 1.15
Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. J Biol Chem (2010) 1.14
ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells. J Cell Physiol (2006) 1.11
Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells. FASEB J (2012) 1.11
Tumor tracking and motion compensation with an adaptive tumor tracking system (ATTS): system description and prototype testing. Med Phys (2008) 1.11
Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol (2012) 1.10
Tankyrase is necessary for canonical Wnt signaling during kidney development. Dev Dyn (2010) 1.09
A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion. Chest (2005) 1.06
Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists. Chest (2009) 1.06
Development and validation of a prognostic model to predict recovery following intracerebral hemorrhage. J Neurol (2006) 1.03
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Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2006) 0.99
Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med (2003) 0.99
Hypoxia modulates the effects of transforming growth factor-beta isoforms on matrix-formation by primary human lung fibroblasts. Cytokine (2003) 0.99
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin Cancer Res (2013) 0.98
The development of highly potent inhibitors for porcupine. J Med Chem (2013) 0.97
Minimally important differences in the Mahler's Transition Dyspnoea Index in a large randomized controlled trial--results from the Scleroderma Lung Study. Rheumatology (Oxford) (2009) 0.97
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97
Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respir Res (2006) 0.96
Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: utility of cycle threshold values of qualitative real-time reverse transcriptase PCR. J Clin Microbiol (2010) 0.93
DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1. Respir Res (2010) 0.93
Urokinase signal transduction and its role in cell migration. FASEB J (2005) 0.92
Large physisorption strain in chemical vapor deposition of graphene on copper substrates. Nano Lett (2012) 0.92
Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2003) 0.91
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Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts. Swiss Med Wkly (2010) 0.86
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Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor. Am J Respir Cell Mol Biol (2002) 0.85
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HGF Expressing Stem Cells in Usual Interstitial Pneumonia Originate from the Bone Marrow and Are Antifibrotic. PLoS One (2013) 0.83
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Phase I trial of bortezomib during maintenance phase after high dose melphalan and autologous stem cell transplantation in patients with multiple myeloma. J Chemother (2012) 0.82
Eltrombopag for the treatment of thrombocytopenia in patients with malignant and non-malignant hematologic disorders. Expert Opin Drug Metab Toxicol (2013) 0.82
Hypoxia differentially enhances the effects of transforming growth factor-beta isoforms on the synthesis and secretion of glycosaminoglycans by human lung fibroblasts. J Pharmacol Exp Ther (2002) 0.82
Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma. Support Care Cancer (2013) 0.81
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Chlamydia pneumoniae activates epithelial cell proliferation via NF-kappaB and the glucocorticoid receptor. Infect Immun (2003) 0.81
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A phase I dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function. Biol Blood Marrow Transplant (2012) 0.80
Calreticulin is a negative regulator of bronchial smooth muscle cell proliferation. J Allergy (Cairo) (2012) 0.79
Dimethylfumarate inhibits CXCL10 via haem oxygenase-1 in airway smooth muscle. Eur Respir J (2012) 0.78
The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids. Synlett (2012) 0.78
Day One Talk: parent preferences when learning that their child has cancer. Support Care Cancer (2013) 0.77
Lung remodeling mechanisms in chronic lung diseases. Curr Opin Allergy Clin Immunol (2014) 0.77
New candidates for vesicle coat proteins. Nat Cell Biol (2004) 0.77
Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease. Respiration (2015) 0.77
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Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. Eur Respir J (2013) 0.77
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Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II trial. Support Care Cancer (2011) 0.76