Published in J Biol Chem on April 06, 2006
The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov (2012) 3.18
The subcellular distribution of calnexin is mediated by PACS-2. Mol Biol Cell (2008) 1.51
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J Biol Chem (2008) 1.22
Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence. Viruses (2012) 1.18
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis. Biochem J (2009) 1.15
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin. Methods Mol Biol (2011) 1.10
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol (2007) 1.08
Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem (2010) 1.03
Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. J Biol Chem (2011) 1.03
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00
An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations. J Mol Biol (2007) 0.99
Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site. PLoS One (2009) 0.97
Nonbonded terms extrapolated from nonlocal knowledge-based energy functions improve error detection in near-native protein structure models. Protein Sci (2007) 0.95
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol (2012) 0.87
The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem (2013) 0.86
The metalloprotease of Listeria monocytogenes is regulated by pH. J Bacteriol (2011) 0.82
Functional analysis of the cucumisin propeptide as a potent inhibitor of its mature enzyme. J Biol Chem (2010) 0.81
Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors. Biol Chem (2011) 0.79
A non-catalytic histidine residue influences the function of the metalloprotease of Listeria monocytogenes. Microbiology (2013) 0.78
The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nat Commun (2015) 0.78
Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry. Anal Chem (2015) 0.77
Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets. Front Pharmacol (2016) 0.76
Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. J Biol Chem (2015) 0.76
Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation. FASEB J (2013) 0.76
Modeling the step of endosomal escape during cell infection by a nonenveloped virus. Biophys J (2012) 0.75
SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res (2003) 25.86
Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol (2002) 6.37
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J (1994) 4.46
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell (1998) 3.79
The proprotein convertases. Curr Opin Chem Biol (1998) 3.79
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J (2005) 3.10
Proteolytic processing in the secretory pathway. J Biol Chem (1999) 2.75
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol (2003) 2.42
Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J Biol Chem (1993) 2.40
alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A (1998) 2.28
PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO J (2001) 2.26
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. EMBO J (1995) 2.22
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion. J Biol Chem (1990) 1.89
Precursor processing by kex2/furin proteases. Chem Rev (2002) 1.88
Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. EMBO J (1997) 1.69
Amino acid, peptide, and protein volume in solution. Annu Rev Biophys Bioeng (1984) 1.59
Regulation of endosome sorting by a specific PP2A isoform. J Cell Biol (1998) 1.51
Purification and characterization of the prohormone convertase PC1(PC3). J Biol Chem (1993) 1.46
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. J Biol Chem (2002) 1.41
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides. J Biol Chem (1999) 1.41
The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution. J Mol Biol (1998) 1.33
Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. Mol Biol Cell (2004) 1.31
Inward rectification in KATP channels: a pH switch in the pore. EMBO J (1999) 1.27
Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting. J Cell Biol (1997) 1.22
Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport. Acta Physiol Scand (2004) 1.19
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing. Trends Biochem Sci (2004) 1.16
Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases. J Biol Chem (1995) 1.16
Functional role of polar amino acid residues in Na+/H+ exchangers. Biochem J (2001) 1.15
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. Biochem J (2003) 1.10
Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases. Biochemistry (2004) 1.08
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules. Proc Natl Acad Sci U S A (2002) 1.07
1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase. Structure (2004) 1.05
Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus. J Mol Biol (2002) 1.01
Folding pathway mediated by an intramolecular chaperone: intrinsically unstructured propeptide modulates stochastic activation of subtilisin. J Mol Biol (2005) 0.94
pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation. Protein Sci (2001) 0.91
Stability and global fold of the mouse prohormone convertase 1 pro-domain. Biochemistry (2001) 0.87
Identification of furin pro-region determinants involved in folding and activation. Biochem J (2004) 0.83
Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem (1993) 0.82
Substrate-induced activation of a trapped IMC-mediated protein folding intermediate. Nat Struct Biol (2001) 0.79
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J (2005) 3.10
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell (2002) 2.27
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J Virol (2003) 1.52
The subcellular distribution of calnexin is mediated by PACS-2. Mol Biol Cell (2008) 1.51
Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM). Biochim Biophys Acta (2010) 1.50
Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem. Front Immunol (2012) 1.50
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. Sci Transl Med (2011) 1.48
Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus. PLoS One (2012) 1.47
Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells. Blood (2006) 1.43
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. J Biol Chem (2002) 1.41
Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata. Biol Chem (2006) 1.37
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem (2004) 1.33
Role of PACS-1 in trafficking of human cytomegalovirus glycoprotein B and virus production. J Virol (2003) 1.31
Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. Mol Biol Cell (2004) 1.31
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe (2007) 1.26
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J (2003) 1.22
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J Biol Chem (2008) 1.22
Biochemical basis of regulation of human copper-transporting ATPases. Arch Biochem Biophys (2007) 1.21
Development of RNA interference revertants in Trypanosoma brucei cell lines generated with a double stranded RNA expression construct driven by two opposing promoters. Mol Biochem Parasitol (2003) 1.20
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A (2006) 1.19
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell (2009) 1.19
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell (2012) 1.18
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clin Cancer Res (2002) 1.17
AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. EMBO Rep (2003) 1.17
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis. Biochem J (2009) 1.15
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. EMBO J (2006) 1.15
Temporal- and strain-specific host microRNA molecular signatures associated with swine-origin H1N1 and avian-origin H7N7 influenza A virus infection. J Virol (2012) 1.12
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin. Methods Mol Biol (2011) 1.10
The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Proc Natl Acad Sci U S A (2004) 1.10
Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell (2010) 1.10
Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases. Biochemistry (2004) 1.08
Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells. J Virol (2002) 1.07
Structural organization of human Cu-transporting ATPases: learning from building blocks. J Biol Inorg Chem (2009) 1.05
The role of RbfA in 16S rRNA processing and cell growth at low temperature in Escherichia coli. J Mol Biol (2003) 1.04
Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol Cell Biol (2008) 1.03
Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A. Biochem Biophys Res Commun (2004) 1.02
Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway. Mol Immunol (2007) 1.00
Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J (2009) 1.00
An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations. J Mol Biol (2007) 0.99
COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 0.98
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog (2012) 0.98
Death by committee: organellar trafficking and communication in apoptosis. Traffic (2009) 0.97
Using local authority data for action on health inequalities: the Caerphilly Health and Social Needs Study. Br J Gen Pract (2002) 0.97
Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression. J Biol Chem (2010) 0.96
Folding pathway mediated by an intramolecular chaperone: dissecting conformational changes coincident with autoprocessing and the role of Ca(2+) in subtilisin maturation. J Biochem (2002) 0.95
A role for SSRP1 in recombination-mediated DNA damage response. J Cell Biochem (2009) 0.95
An ab Initio structural model of a nucleoside permease predicts functionally important residues. J Biol Chem (2009) 0.95
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons. J Neurosci (2009) 0.95
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J Biol Chem (2012) 0.95
Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral cancer cells. Carcinogenesis (2008) 0.94
Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B. J Biol Chem (2009) 0.92
Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family. J Biol Chem (2014) 0.91
The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites. J Biol Chem (2011) 0.90
Small molecule inhibitors of the HIV-1 virulence factor, Nef. Drug Discov Today Technol (2013) 0.90
Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein. J Biol Chem (2014) 0.89
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol (2006) 0.89
An acidic cluster of the cytoplasmic tail of the RD114 virus glycoprotein controls assembly of retroviral envelopes. Traffic (2007) 0.88
Both sequence and context are important for flagellar targeting of a glucose transporter. J Cell Sci (2012) 0.88
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases. Gastroenterology (2006) 0.88
Profibrillin-1 maturation by human dermal fibroblasts: proteolytic processing and molecular chaperones. J Cell Biochem (2003) 0.87
Modulation of PC1/3 activity by self-interaction and substrate binding. Endocrinology (2011) 0.87
Modeling the sound levels produced by bubble release of individual herring. J Acoust Soc Am (2008) 0.87
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol (2012) 0.87
The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem (2013) 0.86
Folding pathway mediated by an intramolecular chaperone. A functional peptide chaperone designed using sequence databases. J Biol Chem (2003) 0.85
Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1). J Biol Chem (2012) 0.85
ORF50-dependent and ORF50-independent activation of the ORF45 gene of Kaposi's sarcoma-associated herpesvirus. Virology (2013) 0.84
Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. Eur J Med Chem (2013) 0.84
Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation. J Virol (2012) 0.84
Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen. Retrovirology (2013) 0.83
Role of the cellular transcription factor YY1 in the latent-lytic switch of Kaposi's sarcoma-associated herpesvirus. Virology (2011) 0.83
Sorting signals required for trafficking of the cysteine-rich acidic repetitive transmembrane protein in Trypanosoma brucei. Eukaryot Cell (2006) 0.82
Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction. J Biol Chem (2005) 0.82