Published in J Biol Chem on January 08, 2014
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance. Oncogene (2015) 0.92
Deubiquitinating enzymes as oncotargets. Oncotarget (2015) 0.91
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. Cell Signal (2014) 0.83
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. PLoS Biol (2016) 0.82
USP11 regulates p53 stability by deubiquitinating p53. J Zhejiang Univ Sci B (2014) 0.79
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells. J Cancer (2016) 0.78
MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation. Oncotarget (2015) 0.78
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni. Parasitol Res (2015) 0.76
Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Sci Rep (2016) 0.76
Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria. Oncotarget (2016) 0.75
TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein. J Virol (2017) 0.75
Surfing the p53 network. Nature (2000) 35.36
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Regulation of p53 stability by Mdm2. Nature (1997) 18.20
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36
Modes of p53 regulation. Cell (2009) 9.31
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol (2004) 4.08
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell (2006) 3.30
USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17
Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature (2004) 2.83
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell (2005) 2.76
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Mol Cell (2011) 1.92
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat Struct Mol Biol (2012) 1.76
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. Structure (2010) 1.63
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol (2003) 1.57
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol (2012) 1.46
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38
Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem (2009) 1.34
JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. EMBO J (2011) 1.28
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26
Techniques for accurate protein identification in shotgun proteomic studies of human, mouse, bovine, and chicken lenses. J Ocul Biol Dis Infor (2009) 1.25
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
MdmX is a substrate for the deubiquitinating enzyme USP2a. Oncogene (2009) 1.18
OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J (2013) 1.09
Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem (2011) 1.06
Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Mol Biol Cell (2010) 1.03
Identification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of Rpn4. J Biol Chem (2006) 1.03
OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem (2009) 1.02
The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition. PLoS One (2009) 1.02
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nat Commun (2013) 1.01
Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol (2004) 4.08
Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol (2008) 2.45
5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem (2007) 2.13
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J (2003) 2.13
Inhibition of c-Myc activity by ribosomal protein L11. EMBO J (2007) 1.78
Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol (2006) 1.72
Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11. J Biol Chem (2008) 1.65
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest (2009) 1.59
Lens proteomics: the accumulation of crystallin modifications in the mouse lens with age. Invest Ophthalmol Vis Sci (2002) 1.55
Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm. J Proteome Res (2005) 1.54
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. J Neurosci (2010) 1.54
Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Biochemistry (2005) 1.51
Molecular architecture of the chick vestibular hair bundle. Nat Neurosci (2013) 1.43
High-throughput identification of proteins and unanticipated sequence modifications using a mass-based alignment algorithm for MS/MS de novo sequencing results. Anal Chem (2004) 1.42
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J (2002) 1.39
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38
Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol (2012) 1.37
Two-dimensional liquid chromatography study of the human whole saliva proteome. J Proteome Res (2004) 1.35
On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure. Food Chem Toxicol (2010) 1.34
MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol (2007) 1.33
The membrane proteome of the mouse lens fiber cell. Mol Vis (2009) 1.30
Accurate annotation of peptide modifications through unrestrictive database search. J Proteome Res (2007) 1.30
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem (2006) 1.29
Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallin. Biochemistry (2002) 1.25
Techniques for accurate protein identification in shotgun proteomic studies of human, mouse, bovine, and chicken lenses. J Ocul Biol Dis Infor (2009) 1.25
Biochemical basis of regulation of human copper-transporting ATPases. Arch Biochem Biophys (2007) 1.21
MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem (2002) 1.20
Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins. Proc Natl Acad Sci U S A (2013) 1.19
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell (2012) 1.18
Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. J Biol Chem (2010) 1.18
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis. Biochem J (2009) 1.15
Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci (2002) 1.15
Identification of a pH sensor in the furin propeptide that regulates enzyme activation. J Biol Chem (2006) 1.14
Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins. Mol Vis (2002) 1.14
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol (2011) 1.13
Ectopic Pax6 expression disturbs lens fiber cell differentiation. Invest Ophthalmol Vis Sci (2004) 1.08
Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases. Biochemistry (2004) 1.08
Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem (2011) 1.06
Structural organization of human Cu-transporting ATPases: learning from building blocks. J Biol Inorg Chem (2009) 1.05
Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation. Biochim Biophys Acta (2009) 1.05
Distinct energy metabolism of auditory and vestibular sensory epithelia revealed by quantitative mass spectrometry using MS2 intensity. Proc Natl Acad Sci U S A (2012) 1.05
The role of RbfA in 16S rRNA processing and cell growth at low temperature in Escherichia coli. J Mol Biol (2003) 1.04
Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Mol Biol Cell (2010) 1.03
Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol Cell Biol (2008) 1.03
Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin. Mol Vis (2007) 1.02
Reliable detection of deamidated peptides from lens crystallin proteins using changes in reversed-phase elution times and parent ion masses. J Proteome Res (2007) 1.02
Laser light-scattering evidence for an altered association of beta B1-crystallin deamidated in the connecting peptide. Protein Sci (2004) 1.02
Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. Mol Cell Proteomics (2002) 1.00
Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J (2009) 1.00
Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity. PLoS One (2011) 0.99
Calpain-specific proteolysis in primate retina: Contribution of calpains in cell death. Invest Ophthalmol Vis Sci (2006) 0.99
An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations. J Mol Biol (2007) 0.99
Role of the retinal vascular endothelial cell in ocular disease. Prog Retin Eye Res (2012) 0.99
Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression. J Biol Chem (2010) 0.99
COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 0.98
The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa. Genes Dev (2010) 0.98
Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles. J Mol Biol (2007) 0.98
Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets. J Am Chem Soc (2014) 0.97
Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion. J Biol Chem (2012) 0.97
Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression. J Biol Chem (2010) 0.96
Conformational selection in substrate recognition by Hsp70 chaperones. J Mol Biol (2012) 0.96
HIF1α protein stability is increased by acetylation at lysine 709. J Biol Chem (2012) 0.96
Folding pathway mediated by an intramolecular chaperone: dissecting conformational changes coincident with autoprocessing and the role of Ca(2+) in subtilisin maturation. J Biochem (2002) 0.95
A role for SSRP1 in recombination-mediated DNA damage response. J Cell Biochem (2009) 0.95
Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas. Curr Diab Rep (2012) 0.95
An ab Initio structural model of a nucleoside permease predicts functionally important residues. J Biol Chem (2009) 0.95
Quantification of isotopically overlapping deamidated and 18o-labeled peptides using isotopic envelope mixture modeling. J Proteome Res (2009) 0.94
Mechanisms of glucagon degradation at alkaline pH. Peptides (2013) 0.93
Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line. Invest Ophthalmol Vis Sci (2003) 0.92
Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B. J Biol Chem (2009) 0.92
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol (2013) 0.92
Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell (2011) 0.91
Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies. PLoS One (2011) 0.91
Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family. J Biol Chem (2014) 0.91
Proteomic and sequence analysis of chicken lens crystallins reveals alternate splicing and translational forms of beta B2 and beta A2 crystallins. Invest Ophthalmol Vis Sci (2004) 0.90
The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites. J Biol Chem (2011) 0.90
Calreticulin binds to gentamicin and reduces drug-induced ototoxicity. Toxicol Sci (2011) 0.88
Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains. J Proteome Res (2011) 0.88
Both sequence and context are important for flagellar targeting of a glucose transporter. J Cell Sci (2012) 0.88
Susceptibility of ovine lens crystallins to proteolytic cleavage during formation of hereditary cataract. Invest Ophthalmol Vis Sci (2008) 0.87
Correlation of actin crosslinker and capper expression levels with stereocilia growth phases. Mol Cell Proteomics (2013) 0.87
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol (2012) 0.87
Verification and spatial localization of aquaporin-5 in the ocular lens. Exp Eye Res (2013) 0.86
The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin. J Biol Chem (2013) 0.86
Folding pathway mediated by an intramolecular chaperone. A functional peptide chaperone designed using sequence databases. J Biol Chem (2003) 0.85
Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF. J Biol Chem (2012) 0.85
Proteomics and phosphoproteomics analysis of human lens fiber cell membranes. Invest Ophthalmol Vis Sci (2013) 0.85
Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1). J Biol Chem (2012) 0.85
Altered patterns of phosphorylation in cultured mouse lenses during development of buthionine sulfoximine cataracts. Exp Eye Res (2002) 0.85
Expressed sequence tag analysis of guinea pig (Cavia porcellus) eye tissues for NEIBank. Mol Vis (2008) 0.84
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. Transgenic Res (2002) 0.84