Published in Small GTPases on January 01, 2014
Brain barriers: Crosstalk between complex tight junctions and adherens junctions. J Cell Biol (2015) 0.91
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration. Mol Biol Evol (2015) 0.83
Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis. BMC Genomics (2015) 0.81
Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis. PLoS One (2015) 0.78
p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood (2016) 0.77
Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function. Exp Cell Res (2017) 0.76
Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans. J Mol Cell Biol (2015) 0.76
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43. Sci Rep (2016) 0.76
Rho GTPases at the crossroad of signaling networks in mammals. Small GTPases (2015) 0.76
The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas. PLoS One (2015) 0.76
The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma. Mol Cancer (2017) 0.76
Control of cell mechanics by RhoA and calcium fluxes during epithelial scattering. Tissue Barriers (2016) 0.75
Tools for Live Imaging of Active Rho GTPases in Xenopus. Genesis (2017) 0.75
Acid fibroblast growth factor preserves blood-brain barrier integrity by activating the PI3K-Akt-Rac1 pathway and inhibiting RhoA following traumatic brain injury. Am J Transl Res (2017) 0.75
GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet (2017) 0.75
Cell-cell adhesion interface: rise of the lateral membrane. F1000Res (2017) 0.75
Role of Cingulin in Agonist-induced Vascular Endothelial Permeability. J Biol Chem (2016) 0.75
KIF17 regulates RhoA-dependent actin remodeling at epithelial cell-cell adhesions. J Cell Sci (2016) 0.75
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol (1990) 7.29
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem (1998) 5.34
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol (1997) 5.15
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol (2002) 4.49
alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol (2010) 4.42
Tight junctions and cell polarity. Annu Rev Cell Dev Biol (2006) 4.39
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell (2006) 4.24
Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol (2010) 3.97
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol (2005) 3.83
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol (2003) 3.77
An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol (2005) 3.74
Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu Rev Cell Biol (1985) 3.68
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr Biol (2000) 3.55
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell (2006) 3.38
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25
ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol (2002) 3.16
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell (2008) 2.99
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A (2007) 2.82
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J Cell Biol (1998) 2.75
Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol (2002) 2.74
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet (2005) 2.71
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta (2003) 2.71
Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sci U S A (1995) 2.70
Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem (1999) 2.68
E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem (2001) 2.63
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol (1998) 2.60
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell (2003) 2.54
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol (2010) 2.51
Adherens junction: molecular architecture and regulation. Cold Spring Harb Perspect Biol (2009) 2.45
The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J (2000) 2.44
Rap1: a key regulator in cell-cell junction formation. J Cell Sci (2007) 2.44
Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. J Cell Biol (1997) 2.42
Desmosome structure, composition and function. Biochim Biophys Acta (2007) 2.31
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol (2012) 2.23
Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol Biol Cell (2006) 2.22
Cytokine regulation of tight junctions. Biochim Biophys Acta (2008) 2.16
Actin dynamics and cell-cell adhesion in epithelia. Curr Opin Cell Biol (2001) 2.15
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell (2012) 1.98
The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol (2007) 1.98
Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol (1999) 1.96
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci (2009) 1.96
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells. J Cell Biol (2006) 1.94
N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol (2011) 1.92
Compartmentalized morphogenesis in epithelia: from cell to tissue shape. Dev Dyn (2005) 1.89
Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol (2000) 1.89
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell (2011) 1.86
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? Trends Cell Biol (2008) 1.80
Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Dev Cell (2005) 1.79
RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol Biol Cell (2001) 1.76
PAK4 mediates morphological changes through the regulation of GEF-H1. J Cell Sci (2005) 1.75
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol (2011) 1.75
Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. J Cell Sci (2007) 1.74
Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. Nat Cell Biol (2011) 1.72
A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions. PLoS One (2007) 1.72
Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol (2012) 1.70
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem (2004) 1.69
Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. J Hum Genet (2010) 1.61
An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell (2011) 1.60
Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. Nat Rev Mol Cell Biol (2014) 1.53
Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells. EMBO J (2001) 1.53
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol (1999) 1.52
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene (2006) 1.49
Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.48
EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. J Cell Biol (2003) 1.48
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell (2012) 1.43
Monomeric α-catenin links cadherin to the actin cytoskeleton. Nat Cell Biol (2013) 1.41
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J Biol Chem (2004) 1.41
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Dev Cell (2011) 1.40
Discovering the molecular components of intercellular junctions--a historical view. Cold Spring Harb Perspect Biol (2009) 1.39
'Putting the squeeze' on the tight junction: understanding cytoskeletal regulation. Semin Cell Dev Biol (2000) 1.38
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem (1999) 1.38
The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nat Cell Biol (2009) 1.36
A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science (2011) 1.32
Microtubules regulate disassembly of epithelial apical junctions. BMC Cell Biol (2006) 1.31
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
Genetic variation in myosin IXB is associated with ulcerative colitis. Gastroenterology (2006) 1.29
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J (2000) 1.26
Formin mDia1 senses and generates mechanical forces on actin filaments. Nat Commun (2013) 1.23
Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early Xenopus embryo. Development (2003) 1.22
Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells (2002) 1.22
Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell (2006) 1.22
A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell (2012) 1.22
ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. Biochem Biophys Res Commun (2008) 1.22
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol (2012) 1.22
JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. J Biol Chem (2004) 1.20
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci (2008) 1.17
Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension. J Cell Biol (2014) 1.16
Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly. Traffic (2007) 1.16
Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation. Proc Natl Acad Sci U S A (2012) 1.16
Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol (2011) 1.06
The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4. PLoS One (2013) 0.79