Published in Cell Metab on May 01, 2006
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Transcriptional control of adipocyte formation. Cell Metab (2006) 9.50
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 5.29
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A (2008) 4.77
Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett (2007) 3.65
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell (2013) 3.63
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med (2014) 3.13
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta (2010) 2.70
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell (2009) 2.44
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell (2011) 2.36
Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y Acad Sci (2008) 2.27
Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A (2007) 2.19
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev (2008) 2.05
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci U S A (2007) 2.03
C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol (2009) 1.98
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol (2013) 1.86
EBF2 determines and maintains brown adipocyte identity. Cell Metab (2013) 1.85
Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology (2010) 1.81
PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev (2008) 1.80
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A (2007) 1.79
The Warburg effect is genetically determined in inherited pheochromocytomas. PLoS One (2009) 1.75
Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation (2013) 1.69
Molecular determinants of brown adipocyte formation and function. Genes Dev (2008) 1.68
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab (2010) 1.64
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol (2009) 1.64
Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc Natl Acad Sci U S A (2012) 1.61
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun (2013) 1.59
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res (2010) 1.55
Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol (2012) 1.55
Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol (2016) 1.53
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci (2011) 1.50
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem (2012) 1.43
PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res (2010) 1.43
Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes (2010) 1.42
Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem (2010) 1.38
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A (2009) 1.38
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism. Mol Endocrinol (2008) 1.37
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2011) 1.35
PPARs in the Control of Uncoupling Proteins Gene Expression. PPAR Res (2007) 1.34
Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations. Am J Pathol (2009) 1.33
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J Biol Chem (2009) 1.31
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem (2011) 1.30
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem (2011) 1.30
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem (2009) 1.24
GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem (2009) 1.23
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab (2013) 1.22
The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death. J Neurochem (2009) 1.21
Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes. Biosci Rep (2013) 1.14
The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J (2009) 1.14
Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol (2012) 1.14
Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Biol (2010) 1.13
Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy. J Biol Chem (2012) 1.13
Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res (2009) 1.10
Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem (2008) 1.10
Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol (2011) 1.09
Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. J Biol Chem (2008) 1.09
Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A (2006) 1.07
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes (2015) 1.07
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. PLoS One (2011) 1.05
Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Res (2011) 1.05
Regulation of gene expression by FSP27 in white and brown adipose tissue. BMC Genomics (2010) 1.04
The brain and brown fat. Ann Med (2014) 1.02
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Biol Chem (2012) 1.02
The many roles of PGC-1α in muscle--recent developments. Metabolism (2014) 1.01
Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice. PLoS One (2008) 1.01
NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem (2012) 1.00
TWEAK/Fn14 Signaling Axis Mediates Skeletal Muscle Atrophy and Metabolic Dysfunction. Front Immunol (2014) 1.00
Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiol (2009) 0.99
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes (2011) 0.98
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol. J Biol Chem (2013) 0.97
Irisin, two years later. Int J Endocrinol (2013) 0.97
MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun (2014) 0.96
The TWEAK-Fn14 system: breaking the silence of cytokine-induced skeletal muscle wasting. Curr Mol Med (2012) 0.96
Nuclear Receptor Cofactors in PPARgamma-Mediated Adipogenesis and Adipocyte Energy Metabolism. PPAR Res (2007) 0.96
Adipose tissues and thyroid hormones. Front Physiol (2014) 0.96
Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J (2013) 0.96
Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. PLoS One (2009) 0.95
Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J (2008) 0.95
Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription. Mol Endocrinol (2008) 0.95
Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun (2015) 0.94
Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Matrix Biol (2011) 0.94
Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol (2013) 0.94
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev (2006) 6.68
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature (2008) 5.85
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 5.29
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell (2003) 4.38
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
Myogenic specification of side population cells in skeletal muscle. J Cell Biol (2002) 3.74
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell (2013) 3.71
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Transcriptional control of preadipocyte determination by Zfp423. Nature (2010) 3.55
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell (2005) 3.54
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol (2006) 3.22
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab (2012) 3.09
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab (2007) 3.05
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol (2004) 3.00
Transcriptional control of brown fat development. Cell Metab (2010) 2.97
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Retracted Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab (2008) 2.80
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
Looking back to the embryo: defining transcriptional networks in adult myogenesis. Nat Rev Genet (2003) 2.70
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A (2008) 2.49
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab (2012) 2.41
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev (2004) 2.39
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am J Hypertens (2010) 2.31
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab (2005) 2.29
The post-natal heart contains a myocardial stem cell population. FEBS Lett (2002) 2.23
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20
Medicine. Beige can be slimming. Science (2010) 2.17
Irisin ERKs the fat. Diabetes (2014) 2.05