Published in Nature on February 21, 2008
Molecular mechanisms and clinical applications of angiogenesis. Nature (2011) 13.36
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Mitochondria: in sickness and in health. Cell (2012) 6.05
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell (2013) 3.63
Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature (2014) 3.31
Retracted Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab (2008) 2.80
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A (2009) 2.50
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Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res (2008) 2.15
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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature (2016) 2.13
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Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011) 1.88
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
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Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest (2012) 1.79
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab (2013) 1.76
Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 1.76
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Molecular determinants of brown adipocyte formation and function. Genes Dev (2008) 1.68
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67
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Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60
Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57
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Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ. Circ Res (2012) 1.51
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A (2008) 1.45
Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ. Cell Metab (2011) 1.43
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Res (2008) 1.42
miRNAs and sports: tracking training status and potentially confounding diagnoses. J Transl Med (2016) 1.41
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Mechanisms of glioma-associated neovascularization. Am J Pathol (2012) 1.39
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A (2009) 1.38
Roles of oxidative stress, apoptosis, PGC-1α and mitochondrial biogenesis in cerebral ischemia. Int J Mol Sci (2011) 1.37
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism. Mol Endocrinol (2008) 1.37
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell (2011) 1.37
PGC-1alpha in aging and anti-aging interventions. Biochim Biophys Acta (2009) 1.35
Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev (2012) 1.33
The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J Biol Chem (2012) 1.32
Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr Cancer (2009) 1.31
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest (2013) 1.30
PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch (2010) 1.29
Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol Rep (2014) 1.28
Exercise rehabilitation in peripheral artery disease: functional impact and mechanisms of benefits. Circulation (2011) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A (2011) 1.23
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circ Heart Fail (2012) 1.23
Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab (2012) 1.22
Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circ Res (2009) 1.20
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. J Biol Chem (2012) 1.19
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis. Genes Dev (2013) 1.18
Update on therapeutic vascularization strategies. Regen Med (2009) 1.17
Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. J Appl Physiol (1985) (2009) 1.17
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16
Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. PLoS One (2008) 1.15
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev (2011) 1.15
Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. PLoS One (2011) 1.14
PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Mol Cell Biol (2010) 1.14
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation (2011) 1.14
The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13
Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair? Front Physiol (2012) 1.12
Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling. PLoS One (2010) 1.12
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med (2012) 1.12
New insights in synovial angiogenesis. Joint Bone Spine (2009) 1.12
Mechanisms by which exercise training benefits patients with heart failure. Nat Rev Cardiol (2009) 1.11
Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep (2013) 1.11
Gene therapy for ischemic heart disease. J Mol Cell Cardiol (2010) 1.11
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Effects of aging on angiogenesis. Circ Res (2012) 1.10
Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer. Anticancer Agents Med Chem (2009) 1.09
Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice. Am J Pathol (2012) 1.09
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med (2014) 1.08
Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem (2010) 1.08
Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A (2013) 1.07
PGC-1 coactivators regulate MITF and the tanning response. Mol Cell (2012) 1.07
Systems biology of pro-angiogenic therapies targeting the VEGF system. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06
Dietary hyperglycemia, glycemic index and metabolic retinal diseases. Prog Retin Eye Res (2010) 1.06
Angiogenesis in wounds treated by microdeformational wound therapy. Ann Surg (2011) 1.05
PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. J Biol Chem (2009) 1.05
Module-based multiscale simulation of angiogenesis in skeletal muscle. Theor Biol Med Model (2011) 1.04
Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease. EMBO Mol Med (2014) 1.04
Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. BMC Cancer (2009) 1.03
Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab (2014) 1.02
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol (2009) 1.02
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet (2012) 1.02
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol (2012) 1.02
Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ. PLoS One (2012) 1.02
Evidence for a relationship between VEGF and BMI independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men. PLoS One (2010) 1.01
The many roles of PGC-1α in muscle--recent developments. Metabolism (2014) 1.01
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med (2006) 9.07
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
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Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res (2004) 4.13
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell (2013) 3.71
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Transcriptional control of preadipocyte determination by Zfp423. Nature (2010) 3.55
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell (2005) 3.54
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem (2002) 3.22
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab (2012) 3.09
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab (2007) 3.05
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol (2004) 3.00
Transcriptional control of brown fat development. Cell Metab (2010) 2.97
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Retracted Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab (2008) 2.80
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
Cardiac cell therapy--mixed results from mixed cells. N Engl J Med (2006) 2.52
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A (2008) 2.49
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest (2008) 2.46
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab (2012) 2.41
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev (2004) 2.39
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest (2005) 2.36
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab (2005) 2.29
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation (2007) 2.19
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell (2009) 2.15
Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging (2009) 2.12
Irisin ERKs the fat. Diabetes (2014) 2.05
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med (2005) 2.03
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 2.00
A20 is dynamically regulated in the heart and inhibits the hypertrophic response. Circulation (2003) 1.94
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol (2010) 1.92
Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res (2006) 1.92
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89