Published in Immunol Res on January 01, 2006
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal (2007) 1.60
Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Crit Care (2011) 1.17
Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Mol Med (2008) 0.90
Endothelial cell injury with inflammatory cytokine and coagulation in patients with sepsis. World J Emerg Med (2013) 0.89
Sepsis: redox mechanisms and therapeutic opportunities. Antioxid Redox Signal (2007) 0.87
Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. Surgery (2009) 0.86
A Review of GM-CSF Therapy in Sepsis. Medicine (Baltimore) (2015) 0.84
SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma (2010) 0.82
New insights for C5a and C5a receptors in sepsis. Front Immunol (2012) 0.79
The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock. Shock (2014) 0.75
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
The enigma of sepsis. J Clin Invest (2003) 4.32
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Adverse functions of IL-17A in experimental sepsis. FASEB J (2008) 2.60
Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature (2007) 2.56
CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury. Am J Pathol (2012) 2.12
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
The complement system. Cell Tissue Res (2010) 1.86
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Generation of C5a by phagocytic cells. Am J Pathol (2002) 1.72
Role of oxidants in lung injury during sepsis. Antioxid Redox Signal (2007) 1.71
Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (2013) 1.57
Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci (2012) 1.57
Regulation by C5a of neutrophil activation during sepsis. Immunity (2003) 1.54
Evidence for a functional role of the second C5a receptor C5L2. FASEB J (2005) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med (2002) 1.51
Evaluation of endotoxin models for the study of sepsis. Shock (2005) 1.47
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Complement-induced impairment of innate immunity during sepsis. J Immunol (2002) 1.44
Protection of innate immunity by C5aR antagonist in septic mice. FASEB J (2002) 1.44
Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol (2004) 1.42
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J (2003) 1.42
Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol (2003) 1.42
Harmful and protective roles of neutrophils in sepsis. Shock (2005) 1.41
High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone (2009) 1.41
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood (2011) 1.39
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med (2008) 1.38
Humanizing the mouse: in defense of murine models of critical illness. Am J Respir Crit Care Med (2013) 1.36
Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model. Free Radic Biol Med (2002) 1.35
The inflammatory response in sepsis. Trends Immunol (2012) 1.34
C5a-induced gene expression in human umbilical vein endothelial cells. Am J Pathol (2004) 1.34
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol (2012) 1.34
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Am J Pathol (2002) 1.33
Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol (2005) 1.33
Regulatory effects of estrogen on acute lung inflammation in mice. Am J Physiol Cell Physiol (2005) 1.32
C5a receptor and thymocyte apoptosis in sepsis. FASEB J (2002) 1.31
Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One (2009) 1.31
Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB). J Biol Chem (2011) 1.31
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. FASEB J (2012) 1.31
Functions of the complement components C3 and C5 during sepsis. FASEB J (2008) 1.30
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med (2005) 1.29
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J Neuroinflammation (2007) 1.24
Immunosuppression in sepsis. JAMA (2011) 1.22
Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol (2008) 1.22
Regulation of lung inflammation in the model of IgG immune-complex injury. Annu Rev Pathol (2006) 1.20
Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. Crit Care (2009) 1.20
Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box? Mol Med (2008) 1.20
Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways. PLoS Pathog (2009) 1.20
Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol (2005) 1.19
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J (2011) 1.19
Stat3 activation in acute lung injury. J Immunol (2004) 1.18
Molecular events in the cardiomyopathy of sepsis. Mol Med (2008) 1.18
Ischemia/reperfusion injury. J Surg Res (2002) 1.16
Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response. PLoS One (2009) 1.16
Complement in ischemia reperfusion injury. Am J Pathol (2003) 1.15
Expression and function of the C5a receptor in rat alveolar epithelial cells. J Immunol (2002) 1.14
Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. Am J Respir Cell Mol Biol (2003) 1.14
Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice. Ann N Y Acad Sci (2010) 1.13
Opportunities and challenges of disease biomarkers: a new section in the Journal of Translational Medicine. J Transl Med (2012) 1.13
In vivo regulation of neutrophil apoptosis by C5a during sepsis. J Leukoc Biol (2006) 1.12
Altered neutrophil trafficking during sepsis. J Immunol (2002) 1.11
Role of endothelial chemokines and their receptors during inflammation. J Invest Surg (2011) 1.11
Attenuation of half sulfur mustard gas-induced acute lung injury in rats. J Appl Toxicol (2006) 1.10
Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci (2006) 1.09
Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology (2013) 1.09
Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect Immun (2010) 1.09
Retracted Opportunities and challenges of disease biomarkers: a new section in the Journal of Translational Medicine. J Transl Med (2012) 1.08
Protection from half-mustard-gas-induced acute lung injury in the rat. J Appl Toxicol (2002) 1.08
Neutrophil C5a receptor and the outcome in a rat model of sepsis. FASEB J (2003) 1.08
Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells. FASEB J (2009) 1.07
Role of C5a-C5aR interaction in sepsis. Shock (2004) 1.07
Genome sequences of wild and domestic bactrian camels. Nat Commun (2012) 1.07
Regulatory role of C5a on macrophage migration inhibitory factor release from neutrophils. J Immunol (2004) 1.07
STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses. Expert Opin Ther Targets (2007) 1.05
The outcome of polymicrobial sepsis is independent of T and B cells. Shock (2011) 1.05
8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radic Biol Med (2011) 1.04
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. PLoS One (2008) 1.03
The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. J Immunol (2007) 1.02
Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest (2016) 1.02
Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J Immunol (2012) 1.02