Published in Nat Methods on August 01, 2006
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Chemically defined conditions for human iPSC derivation and culture. Nat Methods (2011) 5.84
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell (2012) 3.80
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol (2010) 3.70
Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood (2007) 3.05
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell (2010) 2.69
Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat Struct Mol Biol (2012) 2.65
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol (2012) 2.33
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res (2011) 2.30
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods (2010) 2.15
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11
ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. Cell Metab (2016) 2.08
A proteomics grade electron transfer dissociation-enabled hybrid linear ion trap-orbitrap mass spectrometer. J Proteome Res (2008) 1.92
An alternative pluripotent state confers interspecies chimaeric competency. Nature (2015) 1.90
Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A (2010) 1.88
Gas-phase purification enables accurate, multiplexed proteome quantification with isobaric tagging. Nat Methods (2011) 1.87
Efficient feeder-free episomal reprogramming with small molecules. PLoS One (2011) 1.79
Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proc Natl Acad Sci U S A (2011) 1.79
Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc (2012) 1.74
Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72
Controlled differentiation of stem cells. Adv Drug Deliv Rev (2007) 1.72
Pluripotent stem cells derived from adult human testes. Stem Cells Dev (2009) 1.71
Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell Dev Biol Anim (2010) 1.70
Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS One (2009) 1.70
MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev (2007) 1.65
The iCRISPR platform for rapid genome editing in human pluripotent stem cells. Methods Enzymol (2014) 1.64
Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods (2012) 1.58
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. PLoS One (2010) 1.54
Albumin-associated lipids regulate human embryonic stem cell self-renewal. PLoS One (2008) 1.54
The Rho-Rock-Myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells. PLoS One (2008) 1.52
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genet (2007) 1.51
The glycans of stem cells. Curr Opin Chem Biol (2007) 1.45
ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells. Mol Reprod Dev (2009) 1.45
Characterization of integrin engagement during defined human embryonic stem cell culture. FASEB J (2009) 1.43
High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. J Am Chem Soc (2010) 1.41
Multiscale computational models for optogenetic control of cardiac function. Biophys J (2011) 1.34
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions. Genome Biol (2012) 1.33
Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation. Mol Ther (2012) 1.33
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells. Nat Protoc (2011) 1.32
Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle (2010) 1.29
Role of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cells. Cell Adh Migr (2012) 1.27
Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proc Natl Acad Sci U S A (2013) 1.27
Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells (2011) 1.26
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A (2011) 1.25
mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram (2010) 1.21
Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev (2012) 1.20
Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res (2011) 1.19
Innovation in the culture and derivation of pluripotent human stem cells. Curr Opin Biotechnol (2008) 1.18
Inhibition of caspase-mediated anoikis is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells. J Biol Chem (2009) 1.16
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB J (2013) 1.15
Optical mapping discerns genome wide DNA methylation profiles. BMC Mol Biol (2008) 1.14
Cell transplantation strategies for retinal repair. Prog Brain Res (2009) 1.14
Differentiation of hepatocytes from pluripotent stem cells. Curr Protoc Stem Cell Biol (2013) 1.14
Differentiation of neural lineage cells from human pluripotent stem cells. Methods (2008) 1.13
Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med (2013) 1.13
Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol (2010) 1.12
Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors. Tissue Eng Part C Methods (2012) 1.11
Engineered polymer-media interfaces for the long-term self-renewal of human embryonic stem cells. Biomaterials (2011) 1.11
CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell (2016) 1.08
Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture. Stem Cells Transl Med (2014) 1.07
Model systems for studying trophoblast differentiation from human pluripotent stem cells. Cell Tissue Res (2012) 1.05
NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood (2010) 1.04
Derivation of xeno-free and GMP-grade human embryonic stem cells--platforms for future clinical applications. PLoS One (2012) 1.03
Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem Cell Reports (2014) 1.02
Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip (2010) 1.02
Amniocytes can serve a dual function as a source of iPS cells and feeder layers. Hum Mol Genet (2010) 1.02
Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium. PLoS One (2013) 1.01
Secreted proteoglycans directly mediate human embryonic stem cell-basic fibroblast growth factor 2 interactions critical for proliferation. Stem Cells (2008) 1.01
Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells. Stem Cell Reports (2015) 1.00
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nat Commun (2015) 0.99
Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS One (2011) 0.99
Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. PLoS One (2011) 0.99
Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype. PLoS One (2013) 0.98
Current status of drug screening and disease modelling in human pluripotent stem cells. Bioessays (2012) 0.98
Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells. J Cell Sci (2011) 0.98
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions. PLoS One (2010) 0.98
Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells. Stem Cells (2012) 0.98
Efficient culturing and genetic manipulation of human pluripotent stem cells. PLoS One (2011) 0.97
Signaling networks in human pluripotent stem cells. Curr Opin Cell Biol (2012) 0.97
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
Adapting human pluripotent stem cells to high-throughput and high-content screening. Nat Protoc (2012) 0.97
Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J Biol Chem (2009) 0.96
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs. Proc Natl Acad Sci U S A (2014) 0.95
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc (2014) 0.93
A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs. PLoS One (2011) 0.93
The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A (2014) 0.92
Human embryonic stem cell lines model experimental human cytomegalovirus latency. MBio (2013) 0.92
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
RNA-Seq gene expression estimation with read mapping uncertainty. Bioinformatics (2009) 10.74
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol (2003) 9.15
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell (2007) 8.59
Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol (2006) 8.28
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods (2005) 6.37
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
Chemically defined conditions for human iPSC derivation and culture. Nat Methods (2011) 5.84
Homologous recombination in human embryonic stem cells. Nat Biotechnol (2003) 5.77
Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments. Bioinformatics (2013) 4.79
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A (2003) 4.67
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood (2004) 4.32
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res (2007) 3.56
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells (2009) 3.46
Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells (2005) 3.38
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91
Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells (2005) 2.78
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell (2010) 2.69
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood (2006) 2.66
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol (2011) 2.65
A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell (2010) 2.58
Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat (2002) 2.52
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells (2003) 2.42
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41
Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods (2011) 2.39
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells (2011) 2.26
Pluripotent stem cell lines. Genes Dev (2008) 2.25
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21
Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells. Endocrinology (2003) 2.15
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11
A germ cell origin of embryonic stem cells? Development (2005) 2.09
Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol (2007) 2.08
Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing. Proc Natl Acad Sci U S A (2010) 2.01
Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.95
Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood (2011) 1.92
Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc (2012) 1.74
Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72
Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc Natl Acad Sci U S A (2005) 1.71
Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J Virol (2003) 1.57
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genet (2007) 1.51
A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets. Nucleic Acids Res (2008) 1.47
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46
Evaluation of de novo transcriptome assemblies from RNA-Seq data. Genome Biol (2014) 1.46
MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells (2009) 1.43
Arrays for the combinatorial exploration of cell adhesion. J Am Chem Soc (2004) 1.41
Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway. J Immunol (2006) 1.34
Generation of red blood cells from human induced pluripotent stem cells. Stem Cells Dev (2011) 1.25
Functional endothelial cells derived from rhesus monkey embryonic stem cells. Blood (2003) 1.25
The effects of adult guidance and peer discussion on the development of children's representations: evidence from the training of pedestrian skills. Br J Psychol (2005) 1.24
Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood (2005) 1.23
Scalable culture and cryopreservation of human embryonic stem cells on microcarriers. Biotechnol Prog (2009) 1.21
Dielectrophoretic separation of platelets from diluted whole blood in microfluidic channels. Electrophoresis (2008) 1.20
Phosphorylation regulates human OCT4. Proc Natl Acad Sci U S A (2012) 1.19
Human embryonic stem cells reprogram myeloid precursors following cell-cell fusion. Stem Cells (2005) 1.17
LongSAGE profiling of nine human embryonic stem cell lines. Genome Biol (2007) 1.15
Optical mapping discerns genome wide DNA methylation profiles. BMC Mol Biol (2008) 1.14
Quantitative selection and parallel characterization of aptamers. Proc Natl Acad Sci U S A (2013) 1.13
Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema. PLoS Comput Biol (2013) 1.11
Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells. Blood (2011) 1.08
Instant spectral assignment for advanced decision tree-driven mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.08
Differentiation of human embryonic stem cells occurs through symmetric cell division. Stem Cells (2005) 1.04