Published in Proc Natl Acad Sci U S A on February 16, 2010
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
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Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
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Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell (2012) 2.62
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Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Modeling human cortical development in vitro using induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.41
Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods (2011) 2.39
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells (2011) 2.26
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest (2011) 2.23
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat Biotechnol (2011) 2.07
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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum Mol Genet (2011) 1.87
Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci U S A (2010) 1.78
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Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest (2010) 1.66
Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies. J Allergy Clin Immunol (2010) 1.65
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Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci U S A (2011) 1.63
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Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A (2011) 1.52
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One (2010) 1.48
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Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. PLoS One (2014) 1.45
Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44
The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells. Mol Syst Biol (2011) 1.44
Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci (2011) 1.40
Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell (2014) 1.39
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci (2013) 1.38
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Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A (2011) 1.35
Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports (2014) 1.35
Micro-/nanofluidics based cell electroporation. Biomicrofluidics (2013) 1.35
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat Commun (2012) 1.33
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Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells (2012) 1.28
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Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Nat Protoc (2011) 1.20
Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun (2014) 1.18
Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circ Res (2011) 1.17
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Modeling the functional genomics of autism using human neurons. Mol Psychiatry (2011) 1.17
Stem cell technology for the study and treatment of motor neuron diseases. Regen Med (2011) 1.16
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Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry (2012) 1.14
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Technological overview of iPS induction from human adult somatic cells. Curr Gene Ther (2013) 1.13
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Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun (2013) 1.12
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron (2014) 1.11
DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci (2012) 1.11
Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res (2013) 1.08
iPS cells to model CDKL5-related disorders. Eur J Hum Genet (2011) 1.08
EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res (2013) 1.07
Deficits in human trisomy 21 iPSCs and neurons. Proc Natl Acad Sci U S A (2013) 1.07
Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture. Stem Cells Transl Med (2014) 1.07
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Modeling psychiatric disorders through reprogramming. Dis Model Mech (2011) 1.04
Epigenetic and phenotypic profile of fibroblasts derived from induced pluripotent stem cells. PLoS One (2011) 1.01
Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms. J Virol (2010) 1.01
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest (2011) 1.01
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes. PLoS One (2012) 1.01
Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium. PLoS One (2013) 1.01
Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells. PLoS One (2011) 1.01
Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells. Stem Cells (2012) 1.00
Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone. Mol Ther (2011) 1.00
Neural tissue engineering using embryonic and induced pluripotent stem cells. Stem Cell Res Ther (2011) 0.99
Female sex bias in human embryonic stem cell lines. Stem Cells Dev (2011) 0.99
Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector. Nat Protoc (2011) 0.99
Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. J Biol Chem (2013) 0.99
Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction? Gut (2011) 0.98
Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Rep (2013) 0.98
Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy. Cell Res (2012) 0.97
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
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Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol (2009) 13.16
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
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Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
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Specification of motoneurons from human embryonic stem cells. Nat Biotechnol (2005) 7.74
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Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med (2006) 7.21
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature (2009) 7.04
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature (2009) 5.37
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Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells (2009) 2.51
Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc (2009) 2.11
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Regulation of neural specification from human embryonic stem cells by BMP and FGF. Stem Cells (2009) 1.53
Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem Cells (2009) 1.26
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The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
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ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
RNA-Seq gene expression estimation with read mapping uncertainty. Bioinformatics (2009) 10.74
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Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
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Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods (2005) 6.37
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The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
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MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells (2009) 1.43
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Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci (2011) 1.40
Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol (2013) 1.38