Published in Blood on January 03, 2006
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest (2008) 2.26
Arterial thrombosis--insidious, unpredictable and deadly. Nat Med (2011) 1.96
Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem (2010) 1.77
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest (2007) 1.76
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood (2008) 1.45
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood (2009) 1.13
Future innovations in anti-platelet therapies. Br J Pharmacol (2008) 1.13
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem (2010) 1.12
Shaping the platelet response to vascular injury. Curr Opin Hematol (2014) 1.03
Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo. FEBS J (2009) 1.01
Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood (2007) 1.00
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Blood (2007) 0.95
RhoG protein regulates platelet granule secretion and thrombus formation in mice. J Biol Chem (2013) 0.90
Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice. World J Exp Med (2012) 0.90
Critical role for Syk in responses to vascular injury. Blood (2011) 0.88
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb Vasc Biol (2006) 0.87
Platelet Rho GTPases-a focus on novel players, roles and relationships. Biochem J (2015) 0.84
Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice. Blood (2016) 0.84
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost (2008) 0.84
Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. J Biol Chem (2009) 0.80
Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol (2014) 0.79
Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation. Blood (2014) 0.78
Targeting GPVI as a novel antithrombotic strategy. J Blood Med (2014) 0.76
Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow. Haematologica (2015) 0.76
α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis. PLoS One (2014) 0.76
Dynamic and structural formation of a thrombus: the inciting event of arterial ischemic stroke. J Child Neurol (2011) 0.75
Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interv Cardiol Clin (2017) 0.75
New approaches in tail-bleeding assay in mice: improving an important method for designing new anti-thrombotic agents. Int J Exp Pathol (2016) 0.75
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun (2016) 0.75
Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. J Thromb Haemost (2016) 0.75
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood (2008) 1.82
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J (2007) 1.74
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood (2006) 1.63
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood (2011) 1.56
MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther (2005) 1.51
Cardiac tissue engineering in an in vivo vascularized chamber. Circulation (2007) 1.48
Shear-dependent tether formation during platelet translocation on von Willebrand factor. Blood (2002) 1.42
Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol (2003) 1.42
Vasoconstrictor responses to vasopressor agents in human pulmonary and radial arteries: an in vitro study. Anesthesiology (2014) 1.41
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation (2009) 1.40
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J Cell Sci (2002) 1.38
Antiplatelet therapy: in search of the 'magic bullet'. Nat Rev Drug Discov (2003) 1.37
The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program (2011) 1.34
Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem (2001) 1.30
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res (2008) 1.30
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood (2007) 1.29
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem (2004) 1.25
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem (2003) 1.24
Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem (2001) 1.23
Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood (2006) 1.21
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat. Pain (2004) 1.18
A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip (2009) 1.16
Procoagulant platelets: are they necrotic? Blood (2010) 1.15
Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arterioscler Thromb Vasc Biol (2011) 1.15
Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem (2003) 1.13
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem (2009) 1.11
Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury. J Biol Chem (2009) 1.10
Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood (2002) 1.09
Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation. Circ Res (2008) 1.08
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood (2010) 1.07
Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur J Pharmacol (2002) 1.07
Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice. J Biol Chem (2004) 1.05
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. J Biol Chem (2007) 1.04
A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists. Arterioscler Thromb Vasc Biol (2006) 1.04
Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth. J Biol Chem (2004) 1.04
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood (2013) 1.03
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem (2002) 1.01
The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis. J Mol Med (Berl) (2006) 1.01
Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics. Arterioscler Thromb Vasc Biol (2005) 1.01
New insights into the haemostatic function of platelets. Br J Haematol (2009) 1.01
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood (2004) 0.99
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice. Br J Pharmacol (2005) 0.99
Class I phosphoinositide 3-kinases. Int J Biochem Cell Biol (2003) 0.99
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun (2011) 0.99
Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha. Biochem J (2005) 0.98
Persistent depression of contractility and vasodilation with propofol but not with sevoflurane or desflurane in rabbits. Anesthesiology (2008) 0.98
Spectrum of the mutations in Bernard-Soulier syndrome. Hum Mutat (2014) 0.97
Novel role for insulin as an autocrine growth factor for malignant brain tumour cells. Biochem J (2007) 0.97
Advantages of a selective beta-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat. Eur J Pharmacol (2008) 0.97
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res (2011) 0.96
Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood (2012) 0.95
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood (2006) 0.94
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cell Signal (2010) 0.94
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket. Biochem J (2008) 0.94
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem (2009) 0.92
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem (2009) 0.92
Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target. Arterioscler Thromb Vasc Biol (2011) 0.92
Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals. J Pharmacol Toxicol Methods (2005) 0.91
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovasc Res (2008) 0.91
Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform. Blood (2007) 0.90
Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets. J Biol Chem (2005) 0.89