Published in Blood on June 08, 2006
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells. Mol Cell Biol (2007) 1.17
Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network. PLoS One (2011) 1.09
Combinatorial regulation of tissue specification by GATA and FOG factors. Development (2012) 1.06
AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood (2010) 1.05
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation. Blood (2011) 1.04
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun (2015) 0.96
NF-E2 overexpression delays erythroid maturation and increases erythrocyte production. Br J Haematol (2009) 0.95
Transcription factors in late megakaryopoiesis and related platelet disorders. J Thromb Haemost (2013) 0.93
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis. Mol Cell Biol (2010) 0.89
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Sci Signal (2012) 0.88
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood (2009) 0.88
Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis. J Biol Chem (2012) 0.76
Inducible gene targeting in mice. Science (1995) 21.22
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature (1995) 5.42
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J (1997) 4.61
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell (1995) 4.32
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A (1995) 3.47
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol (1999) 3.26
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature (2003) 3.25
Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J (2004) 2.62
Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood (1999) 2.61
Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J (1994) 2.32
Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter. Mol Cell (2001) 2.32
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev (1998) 2.16
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
SCL: from the origin of hematopoiesis to stem cells and leukemia. Exp Hematol (2004) 2.02
The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol (1986) 1.97
Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A (1995) 1.94
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development (1999) 1.92
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain. Proc Natl Acad Sci U S A (2002) 1.91
Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (1999) 1.80
Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood (1995) 1.77
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol (2005) 1.70
The SCL gene: from case report to critical hematopoietic regulator. Blood (1999) 1.65
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood (2005) 1.64
A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol (2001) 1.54
Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost (2003) 1.47
In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol (1995) 1.45
Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood (1999) 1.42
Mechanisms and implications of platelet discoid shape. Blood (2003) 1.42
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene (2002) 1.41
Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells (2001) 1.40
Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood (1984) 1.38
Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy. Proc Natl Acad Sci U S A (1998) 1.37
Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood (2000) 1.31
Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem (2004) 1.30
The demarcation membrane system of the megakaryocyte: a misnomer? Blood (1982) 1.21
SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood (2004) 1.20
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J (1997) 1.09
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene. Mol Cell Biol (2005) 1.02
Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev (2003) 1.01
Platelet production after administration of antiplatelet serum and 5-fluorouracil. Blood (1980) 0.99
Regulation of mouse p45 NF-E2 transcription by an erythroid-specific GATA-dependent intronic alternative promoter. J Biol Chem (2000) 0.91
Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood (2004) 0.90
Functional characterization of the two alternative promoters of human p45 NF-E2 gene. Exp Hematol (2000) 0.86
Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts. Biochem J (1999) 0.81
Effects of c-mpl ligand on cytoplasmic maturation of murine megakaryocytes and on platelet production. J Histochem Cytochem (1998) 0.77
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
Measuring patients' trust in physicians when assessing quality of care. Health Aff (Millwood) (2004) 3.92
Toward a 21st-century health care system: recommendations for health care reform. Ann Intern Med (2009) 3.85
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity (2005) 2.97
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A (2006) 2.90
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science (2010) 2.64
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem (2002) 2.59
Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood (2004) 2.30
Sec15 is an effector for the Rab11 GTPase in mammalian cells. J Biol Chem (2004) 2.24
Development of abbreviated measures to assess patient trust in a physician, a health insurer, and the medical profession. BMC Health Serv Res (2005) 2.18
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
Development of a scale to measure patients' trust in health insurers. Health Serv Res (2002) 1.91
Surgical techniques for parastomal hernia repair: a systematic review of the literature. Ann Surg (2012) 1.84
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood (2008) 1.82
Trust and satisfaction with physicians, insurers, and the medical profession. Med Care (2003) 1.77
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood (2010) 1.76
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J (2007) 1.74
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules. Mol Microbiol (2002) 1.71
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell (2009) 1.69
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev (2002) 1.64
Gene selection from microarray data for cancer classification--a machine learning approach. Comput Biol Chem (2005) 1.64
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood (2006) 1.63
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell (2011) 1.63
Views of potential research participants on financial conflicts of interest: barriers and opportunities for effective disclosure. J Gen Intern Med (2006) 1.63
Pseudoporphyria as a result of voriconazole use: a case report. Int J Dermatol (2004) 1.61
Attitudes of African American and low socioeconomic status white women toward medical research. J Health Care Poor Underserved (2007) 1.58
In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood (2004) 1.58
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood (2012) 1.57
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood (2011) 1.56
How patients' trust relates to their involvement in medical care. J Fam Pract (2005) 1.53
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med (2003) 1.51
Patient reactions to confidentiality, liability, and financial aspects of informed consent in cardiology research. Circ Cardiovasc Qual Outcomes (2010) 1.50
Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population-based data linkage study. Cancer (2014) 1.50
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res (2013) 1.46
Policies of academic medical centers for disclosing financial conflicts of interest to potential research participants. Acad Med (2006) 1.43
Shear-dependent tether formation during platelet translocation on von Willebrand factor. Blood (2002) 1.42
Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J (2008) 1.42
Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol (2003) 1.42
The impact of Blue Cross conversions on health spending and the uninsured. Health Aff (Millwood) (2005) 1.41
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation (2009) 1.40
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect? Nephrol Dial Transplant (2008) 1.39
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J Cell Sci (2002) 1.38
Antiplatelet therapy: in search of the 'magic bullet'. Nat Rev Drug Discov (2003) 1.37
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood (2006) 1.37
Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development. Gene Expr Patterns (2006) 1.35
The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program (2011) 1.34
Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine (Phila Pa 1976) (2004) 1.31
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res (2008) 1.30
Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem (2001) 1.30
Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood (2010) 1.28
Can the Internet be used effectively to provide sex education to young people in China? J Adolesc Health (2006) 1.28
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med (2011) 1.27
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem (2004) 1.25
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem (2003) 1.24
Regional neural tube closure defined by the Grainy head-like transcription factors. Dev Biol (2010) 1.23
Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem (2001) 1.23
Effects of disclosing financial interests on attitudes toward clinical research. J Gen Intern Med (2008) 1.23
A role for pericytes as microenvironmental regulators of human skin tissue regeneration. J Clin Invest (2009) 1.22
Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood (2006) 1.21
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood (2003) 1.20
SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood (2004) 1.20
LIM-domain-only proteins in cancer. Nat Rev Cancer (2013) 1.19
Disclosing conflicts of interest in clinical research: views of institutional review boards, conflict of interest committees, and investigators. J Law Med Ethics (2006) 1.19
The NleE/OspZ family of effector proteins is required for polymorphonuclear transepithelial migration, a characteristic shared by enteropathogenic Escherichia coli and Shigella flexneri infections. Infect Immun (2007) 1.18
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A (2009) 1.18
IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. Biochem J (2007) 1.17
Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter. Mol Cell Biol (2002) 1.17
The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol (2010) 1.17
A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip (2009) 1.16
Procoagulant platelets: are they necrotic? Blood (2010) 1.15