Published in Blood on November 30, 2006
The ageing immune system: is it ever too old to become young again? Nat Rev Immunol (2009) 2.48
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood (2007) 2.16
Immunosenescence: what does it mean to health outcomes in older adults? Curr Opin Immunol (2009) 2.09
Thymic involution and immune reconstitution. Trends Immunol (2009) 1.91
Ghrelin promotes thymopoiesis during aging. J Clin Invest (2007) 1.83
Klotho and aging. Biochim Biophys Acta (2009) 1.58
Thymic T-cell development in allogeneic stem cell transplantation. Blood (2011) 1.53
Causes, consequences, and reversal of immune system aging. J Clin Invest (2013) 1.50
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J Leukoc Biol (2008) 1.40
Changes in primary lymphoid organs with aging. Semin Immunol (2012) 1.40
Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions. Clin Dev Immunol (2012) 1.39
Influenza vaccine responses in older adults. Ageing Res Rev (2010) 1.35
Klotho. Pflugers Arch (2010) 1.34
How I treat adenovirus in hematopoietic stem cell transplant recipients. Blood (2010) 1.29
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol (2009) 1.28
Nonhuman primate models of human immunology. Antioxid Redox Signal (2010) 1.26
Regeneration of the aged thymus by a single transcription factor. Development (2014) 1.23
The effect of age on thymic function. Front Immunol (2013) 1.20
Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal (2011) 1.18
Overview of the FGF23-Klotho axis. Pediatr Nephrol (2009) 1.15
Immunity, ageing and cancer. Immun Ageing (2008) 1.13
Emerging strategies to boost thymic function. Curr Opin Pharmacol (2010) 1.12
CCL25 increases thymopoiesis after androgen withdrawal. Blood (2008) 1.11
Clinical strategies to enhance T cell reconstitution. Semin Immunol (2007) 1.11
A potential link between phosphate and aging--lessons from Klotho-deficient mice. Mech Ageing Dev (2010) 1.10
Factors that may impact on immunosenescence: an appraisal. Immun Ageing (2010) 1.09
Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution. Aging Cell (2010) 1.03
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One (2010) 0.99
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood (2012) 0.96
The role of Klotho in energy metabolism. Nat Rev Endocrinol (2012) 0.95
The immunopathology of thymic GVHD. Semin Immunopathol (2008) 0.94
Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma. Aging Dis (2012) 0.93
Prevention of graft-versus-host disease by anti IL-7Ralpha antibody. Blood (2007) 0.91
Immune reconstitution: how it should work, what's broken, and why it matters. Biol Blood Marrow Transplant (2009) 0.91
The origin and implication of thymic involution. Aging Dis (2011) 0.90
Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. Cell Rep (2014) 0.90
T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/βTREC ratio and thymic naive T cells. Haematologica (2013) 0.89
Is thymocyte development functional in the aged? Aging (Albany NY) (2009) 0.89
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med (2013) 0.88
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation. Blood (2008) 0.87
Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy. Blood (2014) 0.86
Thymic rejuvenation and aging. Curr Opin Immunol (2013) 0.86
Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches. Semin Immunopathol (2008) 0.86
Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling. J Leukoc Biol (2009) 0.85
Impact of aging on viral infections. Microbes Infect (2010) 0.84
Genetic regulation of thymocyte progenitor aging. Semin Immunol (2012) 0.83
Thymic epithelial cell development and its dysfunction in human diseases. Biomed Res Int (2014) 0.83
Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection. Virulence (2016) 0.83
FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors. Stem Cell Reports (2014) 0.81
Young, proliferative thymic epithelial cells engraft and function in aging thymuses. J Immunol (2015) 0.81
The thymus and the immune system: layered levels of control. J Thorac Oncol (2010) 0.81
Premature thymic involution is independent of structural plasticity of the thymic stroma. Eur J Immunol (2015) 0.80
Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus. Aging (Albany NY) (2012) 0.80
Immune senescence: significance of the stromal microenvironment. Clin Exp Immunol (2016) 0.80
Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation. Best Pract Res Clin Haematol (2011) 0.80
HSC Aging and Senescent Immune Remodeling. Trends Immunol (2015) 0.80
Peritransplant palifermin use and lymphocyte recovery after T-cell replete, matched related allogeneic hematopoietic cell transplantation. Am J Hematol (2011) 0.80
Thymus and aging: morphological, radiological, and functional overview. Age (Dordr) (2013) 0.79
Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus. Proc Natl Acad Sci U S A (2015) 0.79
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function. Front Immunol (2015) 0.79
Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age. F1000 Biol Rep (2009) 0.78
Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood (2008) 0.78
Twisting immune responses for allogeneic stem cell therapy. World J Stem Cells (2009) 0.78
Thymic epithelial cell development and differentiation: cellular and molecular regulation. Protein Cell (2013) 0.77
Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models. J Cell Mol Med (2013) 0.77
Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging. Adv Aging Res (2013) 0.76
Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function. PLoS One (2016) 0.76
c-Met signalling is required for efficient postnatal thymic regeneration and repair. Immunology (2015) 0.76
Improving immunity in the elderly: current and future lessons from nonhuman primate models. Age (Dordr) (2011) 0.76
A GMCSF and IL7 fusion cytokine leads to functional thymic-dependent T-cell regeneration in age-associated immune deficiency. Clin Transl Immunology (2015) 0.75
Role of thymic stromal lymphopoietin (TSLP) in palifermin-mediated immune modulation and protection from acute murine graft-versus-host disease. J Clin Immunol (2010) 0.75
A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly. Immune Netw (2015) 0.75
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature (1997) 13.77
Changes in thymic function with age and during the treatment of HIV infection. Nature (1998) 10.27
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med (2005) 9.47
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med (1995) 7.52
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest (2004) 7.00
Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med (1995) 6.77
The aging of hematopoietic stem cells. Nat Med (1996) 6.67
Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem (2006) 6.50
Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med (2004) 6.26
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Age-associated characteristics of murine hematopoietic stem cells. J Exp Med (2000) 4.65
T cell responses are better correlates of vaccine protection in the elderly. J Immunol (2006) 4.38
Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol (1993) 2.96
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood (2006) 2.72
Two genetically separable steps in the differentiation of thymic epithelium. Science (1996) 2.66
The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol (2000) 2.58
The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol (2000) 2.52
Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol (2002) 2.48
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development (1992) 2.34
Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood (1999) 2.22
Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature (2001) 2.18
Generation of functional thymocytes in the human adult. Immunity (1999) 2.10
Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A (1998) 2.10
Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol (2004) 1.92
Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res (1998) 1.82
The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J Immunol (1998) 1.75
Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly. Exp Gerontol (2002) 1.74
Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature (1995) 1.71
Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting. J Clin Oncol (2006) 1.68
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood (2005) 1.65
Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J Immunol (2001) 1.63
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med (2005) 1.59
Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood (2002) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
Identification and characterization of thymic epithelial progenitor cells. Immunity (2002) 1.53
The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine (2005) 1.50
Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol (1996) 1.37
Analysis of the human thymic perivascular space during aging. J Clin Invest (1999) 1.36
Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood (1999) 1.36
Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur J Immunol (1998) 1.35
Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol (1993) 1.26
Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood (1998) 1.25
Molecular and cellular events in early thymocyte development. Adv Immunol (1998) 1.24
Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp Gerontol (2002) 1.24
Connection between B lymphocyte and osteoclast differentiation pathways. J Immunol (2001) 1.22
Cellular and molecular events during early thymus development. Immunol Rev (2006) 1.19
Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice. Am J Pathol (1999) 1.19
Human skin cells support thymus-independent T cell development. J Clin Invest (2005) 1.11
Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol (1997) 1.11
Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors. J Exp Med (2003) 1.10
Thymic regeneration: teaching an old immune system new tricks. Trends Mol Med (2002) 1.08
Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol (2001) 1.08
KGF prevents hydrogen peroxide-induced increases in airway epithelial cell permeability. Am J Physiol (1997) 0.97
Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation. Clin Immunol (2005) 0.97
In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors. Eur J Immunol (1990) 0.97
Age-associated thymic atrophy is not associated with a deficiency in the CD44(+)CD25(-)CD3(-)CD4(-)CD8(-) thymocyte population. Cell Immunol (2001) 0.95
Thymic atrophy in the mouse is a soluble problem of the thymic environment. Vaccine (2000) 0.95
Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. J Clin Immunol (1995) 0.94
Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell Immunol (1986) 0.94
Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Immunity (1997) 0.93
Loss of SDF-1 receptor expression during positive selection in the thymus. Int Immunol (1998) 0.92
The murine thymic microenvironment: changes with age. Int Arch Allergy Immunol (1996) 0.92
Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10. Genes Immun (2003) 0.87
Impairment of B lymphopoiesis in precocious aging (klotho) mice. Int Immunol (2000) 0.85
Age-related decline in humoral immunity caused by the selective loss of TH cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of TDTH cells in SAMP1 mice. Mech Ageing Dev (1997) 0.84
Epithelial cell-specific laminin 5 is required for survival of early thymocytes. J Immunol (2000) 0.83
Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors. J Histochem Cytochem (2003) 0.80
Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood (2005) 7.28
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood (2004) 7.09
Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood (2007) 6.45
Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med (2004) 6.26
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med (2010) 6.24
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2010) 5.79
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood (2002) 5.72
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol (2007) 5.31
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest (2007) 4.44
Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol (2007) 3.65
Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood (2009) 3.62
Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood (2003) 3.42
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (2006) 3.40
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity (2010) 3.35
Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31
Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems. Biol Blood Marrow Transplant (2002) 3.29
Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity (2009) 3.21
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood (2011) 3.18
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med (2012) 3.17
Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10
Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol (2009) 3.06
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood (2004) 2.90
Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med (2010) 2.82
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol (2011) 2.69
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood (2004) 2.63
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
In vivo survival and homeostatic proliferation of natural killer cells. J Exp Med (2003) 2.59
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol (2008) 2.55
Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors. Blood (2008) 2.53
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease. Blood (2009) 2.50
Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol (2002) 2.48
Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng Part A (2010) 2.44
The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol (2011) 2.34
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood (2011) 2.33
Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol (2005) 2.31
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood (2004) 2.28
Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells (2010) 2.25
Acute graft-versus-host disease: from the bench to the bedside. Blood (2009) 2.24
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood (2008) 2.24
IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med (2007) 2.23
Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study. Arthritis Rheum (2009) 2.20
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med (2013) 2.18
Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med (2002) 2.17
Leukocyte migration and graft-versus-host disease. Blood (2005) 2.17
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol (2003) 2.16
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med (2011) 2.14
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood (2007) 2.12
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood (2002) 2.03
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med (2013) 2.03
Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med (2008) 2.02
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med (2008) 2.01
A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer. Cytotherapy (2010) 1.99
Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc (2008) 1.98
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity (2013) 1.98
The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP. Blood (2003) 1.97
Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients. Blood (2006) 1.92
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood (2005) 1.89
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
CD28 costimulation is essential for human T regulatory expansion and function. J Immunol (2008) 1.86
Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib. Proc Natl Acad Sci U S A (2004) 1.85
Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood (2012) 1.85
TALEN-based gene correction for epidermolysis bullosa. Mol Ther (2013) 1.84
A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med (2012) 1.84
Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk Res (2009) 1.84
Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. Cancer Res (2012) 1.84
mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia. Proc Natl Acad Sci U S A (2004) 1.83
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood (2008) 1.82
In vivo imaging of graft-versus-host-disease in mice. Blood (2004) 1.78
Natural killer-cell differentiation by myeloid progenitors. Blood (2010) 1.75