Published in PLoS One on February 08, 2010
A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse. BMC Dev Biol (2010) 1.92
Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth. Aging Cell (2011) 1.17
Mechanisms of thymus organogenesis and morphogenesis. Development (2011) 1.10
Thymus involution and regeneration: two sides of the same coin? Nat Rev Immunol (2013) 0.99
β-catenin/TCF-1 pathway in T cell development and differentiation. J Neuroimmune Pharmacol (2012) 0.97
Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium. Mol Hum Reprod (2011) 0.90
Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis. Int J Biol Sci (2012) 0.89
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis. J Exp Med (2013) 0.89
Characterization of the expression of cytokeratins 5, 8, and 14 in mouse thymic epithelial cells during thymus regeneration following acute thymic involution. Anat Cell Biol (2011) 0.88
Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. PLoS One (2014) 0.86
Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS One (2013) 0.85
Thymic epithelial cell development and its dysfunction in human diseases. Biomed Res Int (2014) 0.83
Increased epithelial-free areas in thymuses with altered EphB-mediated thymocyte-thymic epithelial cell interactions. Histochem Cell Biol (2017) 0.79
Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Sci Rep (2015) 0.79
Wnt signaling influences the development of murine epidermal Langerhans cells. J Invest Dermatol (2011) 0.78
FOXN1 in thymus organogenesis and development. Eur J Immunol (2016) 0.77
WNT signaling suppression in the senescent human thymus. J Gerontol A Biol Sci Med Sci (2014) 0.77
Thymic epithelial cell development and differentiation: cellular and molecular regulation. Protein Cell (2013) 0.77
Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation. Immun Ageing (2015) 0.76
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol (1998) 9.24
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A (2001) 6.07
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol (2006) 3.98
p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev (2006) 3.66
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell (2008) 3.62
WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol (2008) 3.46
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell (1997) 3.23
Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol (2000) 3.23
Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol (1999) 3.15
Bone marrow origin of Ia-positive cells in the medulla rat thymus. J Exp Med (1981) 3.11
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
The Wnts. Genome Biol (2001) 2.90
miR-203 represses 'stemness' by repressing DeltaNp63. Cell Death Differ (2008) 2.86
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood (2006) 2.72
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature (1996) 2.50
Lymphostromal interactions in thymic development and function. Nat Rev Immunol (2001) 2.44
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation. Blood (2008) 2.37
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature (2006) 2.32
Critical involvement of Tcf-1 in expansion of thymocytes. J Immunol (1998) 2.28
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nat Immunol (2001) 2.27
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A (2008) 2.24
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 2.23
Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A (1998) 2.10
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. Curr Biol (2001) 2.06
Self-representation in the thymus: an extended view. Nat Rev Immunol (2004) 1.98
A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell (2002) 1.98
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol (2002) 1.73
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood (2006) 1.71
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol (2001) 1.63
Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development (2000) 1.62
Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J Invest Dermatol (2007) 1.60
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J (2002) 1.57
Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol (2002) 1.56
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur J Immunol (1991) 1.53
Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol (2007) 1.46
Checkpoints in the development of thymic cortical epithelial cells. J Immunol (2009) 1.40
Effects of castration on thymocyte development in two different models of thymic involution. J Immunol (2005) 1.38
Analysis of the human thymic perivascular space during aging. J Clin Invest (1999) 1.36
Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol (2002) 1.33
A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity (2001) 1.32
WNT signaling and lymphocyte development. Cell (2002) 1.32
Head in the WNT: the molecular nature of Spemann's head organizer. Trends Genet (1999) 1.31
beta-Catenin expression enhances generation of mature thymocytes. Int Immunol (2003) 1.31
Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med (1996) 1.31
Recent thymic emigrants are distinct from most medullary thymocytes. Eur J Immunol (1997) 1.30
Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol (2006) 1.28
Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules. Proc Natl Acad Sci U S A (2006) 1.24
Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J Exp Med (1992) 1.22
Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J Immunol (2008) 1.20
Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J Immunol (2006) 1.12
Thymic microenvironments, 3-D versus 2-D? Semin Immunol (1999) 1.12
Thymic epithelial cells provide WNT signals to developing thymocytes. Eur J Immunol (2003) 1.11
PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches. Blood (2006) 1.10
Architectural changes in the thymus of aging mice. Aging Cell (2008) 1.05
Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours. Virchows Arch (2003) 1.01
The Wnt signaling antagonist Kremen1 is required for development of thymic architecture. Clin Dev Immunol (2006) 1.00
Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol (2009) 0.99
Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol (2007) 0.96
Understanding the mechanism of the age-change of thymic function to promote T cell differentiation. Immunol Lett (1994) 0.94
Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1. Int J Dev Biol (2002) 0.94
The murine thymic microenvironment: changes with age. Int Arch Allergy Immunol (1996) 0.92
T cell function and expression are dramatically altered in T cell receptor V gamma 1.1J gamma 4C gamma 4 transgenic mice. Cell (1989) 0.91
Expression of p63 in thymomas and normal thymus. Am J Clin Pathol (2007) 0.91
Differential effects of gonadectomy on thymic stromal cells in promoting T cell differentiation in mice. Mech Ageing Dev (1995) 0.86
Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells. J Exp Med (1996) 0.86
Morphological and immunohistochemical changes to thymic epithelial cells in the irradiated and recovering rat thymus. Arch Histol Cytol (2004) 0.80
Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes. Int Immunol (2004) 0.80
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem (2011) 1.51
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 1.51
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
The mammary bud as a skin appendage: unique and shared aspects of development. J Mammary Gland Biol Neoplasia (2006) 1.39
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A (2012) 1.19
Wnt/β-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells Dev (2010) 1.17
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol (2004) 1.04
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development (2013) 1.02
The Wnt signaling antagonist Kremen1 is required for development of thymic architecture. Clin Dev Immunol (2006) 1.00
A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS One (2010) 0.97
A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet (2005) 0.96
Hairy math: insights into hair-follicle spacing and orientation. Cell (2007) 0.91
Control by a hair's breadth: the role of microRNAs in the skin. Cell Mol Life Sci (2012) 0.90
Thymic nurse cells: a microenvironment for thymocyte development and selection. Int Rev Cytol (2003) 0.88
Cell biology: The not-so-odd couple. Nature (2009) 0.87
Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS One (2013) 0.85
MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest (2015) 0.81
Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction. Exp Biol Med (Maywood) (2007) 0.81
Wnt signaling influences the development of murine epidermal Langerhans cells. J Invest Dermatol (2011) 0.78
Concise review: custodians of the transcriptome: how microRNAs guard stemness in squamous epithelia. Stem Cells (2015) 0.78
The identification of thymic nurse cells in vivo and the role of cytoskeletal proteins in thymocyte internalization. Cell Immunol (2004) 0.78
Defining the hair follicle stem cell (Part II). J Cutan Pathol (2009) 0.76
miRNAs: Miracle or Mirage?: The Limes Against the Barbaric Floods of Leaky and Undesired Transcripts. Organogenesis (2007) 0.75
Defining the hair follicle stem cell (Part I). J Cutan Pathol (2009) 0.75