Published in J Clin Immunol on December 15, 2010
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med (2002) 6.11
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood (2002) 5.72
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science (1989) 4.79
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med (2002) 3.70
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol (2000) 3.42
Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science (1994) 3.21
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood (2004) 2.90
A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol (1994) 2.87
Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol (2001) 2.85
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood (2005) 2.65
Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood (2004) 2.20
Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. J Immunol (2007) 2.19
Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease. J Exp Med (1992) 2.16
Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res (1998) 1.82
Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest (1993) 1.75
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood (2006) 1.71
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood (2005) 1.65
Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J Clin Invest (1994) 1.64
Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem (1990) 1.62
Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood (2002) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol (2008) 1.40
Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol (1996) 1.37
Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood (1999) 1.36
Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. J Exp Med (1994) 1.32
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J Allergy Clin Immunol (2008) 1.30
Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J Immunol (2008) 1.28
Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool. Stem Cells (2008) 1.26
Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood (1998) 1.25
Human keratinocyte growth factor effects in a porcine model of epidermal wound healing. J Exp Med (1993) 1.24
Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors. J Immunol (1998) 1.24
Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. Am J Pathol (1994) 1.21
Early secondary disease in the Rhesus monkey. I. A comparative histopathologic study. Lab Invest (1969) 1.21
Nitric oxide mediates intestinal pathology in graft-vs.-host disease. Eur J Immunol (1992) 1.12
Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clin Immunol (2008) 1.06
Keratinocyte growth factor causes proliferation of urothelium in vivo. J Urol (1995) 1.02
Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Cancer Res (1997) 0.98
The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene (1997) 0.97
KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol (1997) 0.96
Effect of recombinant human keratinocyte growth factor (rHuKGF) on the immunopathogenesis of intestinal graft-vs.-host disease induced without a preconditioning regimen. J Clin Immunol (2004) 0.87
Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output. J Immunol (2007) 0.87
An analysis of pulmonary natural killer cell activity in F1-hybrid mice with acute graft-versus-host reactions. Transplantation (1988) 0.85
The role of interferon-gamma, nitric oxide and lipopolysaccharide in intestinal graft-versus-host disease developing in F1-hybrid mice. Immunology (2003) 0.81
Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol (2008) 0.81
Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol (2000) 0.80
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57
Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol (2008) 4.90
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med (2005) 4.60
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol (2004) 4.43
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med (2007) 4.42
A role for TSLP in the development of inflammation in an asthma model. J Exp Med (2005) 4.08
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol (2005) 4.04
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest (2011) 3.59
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood (2008) 3.52
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature (2012) 3.48
The molecular basis of IL-21-mediated proliferation. Blood (2007) 2.90
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A (2009) 2.83
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev (2006) 2.71
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity (2013) 2.69
NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A (2009) 2.56
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 2.47
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A (2009) 2.46
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25
Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev (2004) 2.18
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity (2012) 2.16
Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. J Immunol (2007) 2.03
IL-21 mediates suppressive effects via its induction of IL-10. J Immunol (2009) 2.00
BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature (2012) 2.00
IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.96
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem (2002) 1.85
In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res (2003) 1.81
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol (2004) 1.75
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci U S A (2008) 1.74
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood (2008) 1.68
A role for Stat5 in CD8+ T cell homeostasis. J Immunol (2003) 1.64
Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta. J Biol Chem (2005) 1.55
IL-21 and T follicular helper cells. Int Immunol (2009) 1.54
The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol (2008) 1.51
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A (2010) 1.50
Calcium-dependent activation of interleukin-21 gene expression in T cells. J Biol Chem (2005) 1.47
TSLP: finally in the limelight. Nat Immunol (2002) 1.47
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem (2004) 1.47
Surveillance biopsies are superior to functional studies for the diagnosis of acute and chronic renal allograft pathology in children. Pediatr Transplant (2004) 1.46
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157. 1993. J Immunol (2008) 1.44
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood (2008) 1.43
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. J Immunol (2010) 1.39
The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J (2002) 1.36
Thymic stromal lymphopoietin: a new cytokine in asthma. Curr Opin Pharmacol (2008) 1.35
Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol (2008) 1.32
Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection. J Immunol (2008) 1.30
Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol (2011) 1.30
Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med (2003) 1.29
Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J Biol Chem (2002) 1.28
Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol (2011) 1.28
Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol (2011) 1.26
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol (2011) 1.25
The transcription factor GABP is a critical regulator of B lymphocyte development. Immunity (2007) 1.24
The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol (2008) 1.23
Defective B cell responses in the absence of SH2D1A. Proc Natl Acad Sci U S A (2005) 1.21
Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol (2013) 1.18
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood (2011) 1.12
T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem (2008) 1.10
Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol (2005) 1.10
Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol (2008) 1.08
IL-21 promotes the pathologic immune response to pneumovirus infection. J Immunol (2012) 1.06
Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med (2013) 1.06
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity (2013) 1.06
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. Proc Natl Acad Sci U S A (2014) 1.05
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog (2013) 1.03
Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol (2012) 1.03
Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A (2013) 1.02
Critical role for Rsk2 in T-lymphocyte activation. Blood (2007) 1.02
Angiostatic activity of the antitumor cytokine interleukin-21. Blood (2008) 0.98
Cytokine mediators of Th17 function. Eur J Immunol (2009) 0.97
Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol (2005) 0.96
Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci U S A (2011) 0.94
Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol (2004) 0.94
Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2. Int Immunol (2002) 0.93
Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93
IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response. Diabetes (2011) 0.92
IL-21 is an immune activator that also mediates suppression via IL-10. Crit Rev Immunol (2010) 0.90
Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol (2006) 0.89
Effect of recombinant human keratinocyte growth factor (rHuKGF) on the immunopathogenesis of intestinal graft-vs.-host disease induced without a preconditioning regimen. J Clin Immunol (2004) 0.87
GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression. FASEB J (2007) 0.87
Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease. J Immunol (2010) 0.85
The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Blood (2008) 0.85
Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function. Mol Cell Biol (2008) 0.84
Th17 cell-derived IL-17 is dispensable for B cell antibody production. Cytokine (2012) 0.84
A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis (2013) 0.83
A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood (2007) 0.83
p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood (2011) 0.83
The role of interferon-gamma, nitric oxide and lipopolysaccharide in intestinal graft-versus-host disease developing in F1-hybrid mice. Immunology (2003) 0.81
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow. J Immunol (2011) 0.81
Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol (2008) 0.81