Published in Nat Rev Mol Cell Biol on January 01, 2007
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev (2007) 10.15
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol (2007) 4.90
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol (2009) 4.57
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35
On the road to reading the RNA-interference code. Nature (2009) 4.33
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae. J Cell Biol (2007) 3.98
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components. Genes Dev (2007) 3.75
NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64
C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature (2014) 3.59
The control of mRNA decapping and P-body formation. Mol Cell (2008) 3.58
P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol (2008) 3.45
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell (2009) 3.05
Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol (2009) 3.01
The Argonaute protein family. Genome Biol (2008) 2.83
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science (2011) 2.78
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol (2008) 2.76
Biogenesis, turnover, and mode of action of plant microRNAs. Plant Cell (2013) 2.65
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
Analysis of P-body assembly in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.37
RNA granules: the good, the bad and the ugly. Cell Signal (2010) 2.31
Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assembly. Proc Natl Acad Sci U S A (2007) 2.30
Co-translational mRNA decay in Saccharomyces cerevisiae. Nature (2009) 2.29
Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? Dev Cell (2009) 2.29
The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell (2008) 2.25
P bodies, stress granules, and viral life cycles. Cell Host Microbe (2008) 2.23
Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Plant Cell (2007) 2.21
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol (2012) 2.19
A multifunctional human Argonaute2-specific monoclonal antibody. RNA (2008) 2.17
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet (2009) 2.11
A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J (2009) 2.06
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res (2008) 2.06
Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. Mol Cell (2010) 2.01
HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells. Mol Biol Cell (2010) 2.00
Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol (2008) 1.98
Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets. Genome Res (2009) 1.98
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90
Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. Mol Cell Biol (2007) 1.85
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol Biol Cell (2007) 1.83
Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae. Mol Biol Cell (2007) 1.83
P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes. Biol Reprod (2010) 1.77
Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation. Genome Res (2012) 1.77
Mechanisms of deadenylation-dependent decay. Wiley Interdiscip Rev RNA (2010) 1.69
The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J (2013) 1.68
Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol (2009) 1.67
Structural basis of dcp2 recognition and activation by dcp1. Mol Cell (2008) 1.65
Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res (2010) 1.64
Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping. Mol Cell Biol (2007) 1.64
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol (2008) 1.60
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol (2008) 1.60
3' Terminal oligo U-tract-mediated stimulation of decapping. RNA (2007) 1.59
Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay. Mol Biol Cell (2011) 1.54
Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell (2014) 1.52
Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. PLoS One (2010) 1.51
Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA (2010) 1.51
Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression. RNA (2009) 1.50
Functional dissection of the human TNRC6 (GW182-related) family of proteins. Mol Cell Biol (2009) 1.49
An RNA pseudoknot is required for production of yellow fever virus subgenomic RNA by the host nuclease XRN1. J Virol (2010) 1.49
piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline. J Cell Biol (2009) 1.46
Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci (2009) 1.46
DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol (2010) 1.45
Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem (2008) 1.45
The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation. Proc Natl Acad Sci U S A (2011) 1.43
Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. PLoS One (2015) 1.43
A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol (2016) 1.42
The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization. PLoS Biol (2015) 1.42
The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res (2009) 1.42
Circular reasoning: microRNAs and cell-cycle control. Trends Biochem Sci (2008) 1.41
Manipulation of cellular processing bodies and their constituents by viruses. DNA Cell Biol (2013) 1.40
P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages. J Virol (2010) 1.40
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acids Res (2010) 1.39
Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching. Proc Natl Acad Sci U S A (2008) 1.39
miRNA regulation of cytokine genes. Cytokine (2009) 1.39
A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay. Mol Cell Biol (2007) 1.38
INCREASED SIZE EXCLUSION LIMIT 2 encodes a putative DEVH box RNA helicase involved in plasmodesmata function during Arabidopsis embryogenesis. Plant Cell (2007) 1.36
Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36
Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. Mol Biol Cell (2009) 1.36
Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Mol Cell (2011) 1.36
Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus. Plant Cell (2009) 1.35
The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies. Mol Biol Cell (2007) 1.35
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc Natl Acad Sci U S A (2008) 1.35
The code within the code: microRNAs target coding regions. Cell Cycle (2010) 1.35
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. J Biol Chem (2010) 1.34
Poliovirus-mediated disruption of cytoplasmic processing bodies. J Virol (2010) 1.34
The role of tristetraprolin in cancer and inflammation. Front Biosci (Landmark Ed) (2012) 1.33
Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol (2010) 1.33
NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A (2010) 1.32
MicroRNAs: molecular features and role in cancer. Front Biosci (Landmark Ed) (2012) 1.32
Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev (2006) 8.78
Getting to the root of miRNA-mediated gene silencing. Cell (2008) 7.17
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol (2008) 5.57
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA (2005) 5.15
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol (2007) 4.90
Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol (2005) 4.45
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38
Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA (2005) 3.11
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell (2011) 2.80
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature (2004) 2.80
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA (2005) 2.59
REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol (2002) 2.55
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol (2004) 2.36
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett (2007) 2.22
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J (2007) 2.11
A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol (2003) 2.11
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11
A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol (2003) 2.03
An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol (2002) 1.71
Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J (2003) 1.70
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J (2010) 1.64
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep (2005) 1.63
Complex genomic rearrangements lead to novel primate gene function. Genome Res (2005) 1.62
Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A (2011) 1.56
Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev (2006) 1.51
Identification of modified residues in RNAs by reverse transcription-based methods. Methods Enzymol (2007) 1.48
Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J (2005) 1.47
Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet (2009) 1.46
Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell (2009) 1.43
The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res (2009) 1.42
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39
Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J (2011) 1.29
The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev (2013) 1.29
Antagonistic factors control the unproductive splicing of SC35 terminal intron. Nucleic Acids Res (2009) 1.28
RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol (2004) 1.26
A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol (2007) 1.23
HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol (2010) 1.23
Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol (2008) 1.22
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res (2012) 1.19
Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol (2002) 1.18
GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J (2013) 1.17
CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev (2011) 1.14
A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol (2012) 1.13
The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol (2013) 1.13
Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep (2004) 1.09
NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol (2013) 1.09
DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A (2009) 1.08
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08
A conserved splicing mechanism of the LMNA gene controls premature aging. Hum Mol Genet (2011) 1.07
The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res (2012) 1.07
The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev (2013) 1.07
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev (2014) 1.04
Combined in silico and experimental identification of the Pyrococcus abyssi H/ACA sRNAs and their target sites in ribosomal RNAs. Nucleic Acids Res (2008) 1.04
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res (2012) 1.03
The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA (2008) 1.02
Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol (2013) 1.02
The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J (2010) 1.00
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev (2013) 0.99
The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics (2003) 0.97
A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol (2012) 0.97
Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell (2013) 0.95
Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms. J Biol Chem (2011) 0.94
Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol (2011) 0.93
miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res (2013) 0.93
The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res (2014) 0.92
NMR assignment of the Drosophila Argonaute2 PAZ domain. J Biomol NMR (2004) 0.91
RNAi: finding the elusive endonuclease. RNA (2004) 0.88
RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p. J Biol Chem (2008) 0.85
A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol (2013) 0.79
A tiny helper lightens the maternal load. Cell (2006) 0.77
Directing mRNA export. Nat Struct Mol Biol (2004) 0.77
Making sense of nonsense. Nat Struct Mol Biol (2013) 0.77
Fluorescence in situ hybridization of small non-coding RNAs. Methods Mol Biol (2015) 0.76
Probing small non-coding RNAs structures. Methods Mol Biol (2015) 0.76
Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep (2007) 0.75