Published in Mol Cell on November 19, 2004
RNA granules. J Cell Biol (2006) 7.79
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
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Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae. J Cell Biol (2007) 3.98
Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell (2006) 3.75
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Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev (2007) 3.14
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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol (2008) 2.61
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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54
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Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules. J Virol (2006) 2.50
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Nonsense-mediated mRNA decay (NMD) mechanisms. Nat Struct Mol Biol (2009) 2.31
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
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Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
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Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping. Mol Cell Biol (2007) 1.64
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Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44
Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. Mol Cell Biol (2006) 1.44
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies. Mol Biol Cell (2007) 1.35
RNA under attack: cellular handling of RNA damage. Crit Rev Biochem Mol Biol (2009) 1.32
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A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev (2009) 1.25
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Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons. Mol Cell Biol (2007) 1.18
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res (2007) 1.18
Stress granules, P-bodies and cancer. Biochim Biophys Acta (2014) 1.17
Mitochondria associate with P-bodies and modulate microRNA-mediated RNA interference. J Biol Chem (2011) 1.13
Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes Dev (2014) 1.13
Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. RNA (2006) 1.11
TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Nucleic Acids Res (2010) 1.09
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08
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A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay. Nucleic Acids Res (2009) 1.03
Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res (2011) 1.00
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol (2011) 1.00
Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol (2013) 1.00
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SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay. Nucleic Acids Res (2012) 0.98
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Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans (2009) 0.96
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7-Pat1 complex. RNA (2009) 0.94
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LSM proteins provide accurate splicing and decay of selected transcripts to ensure normal Arabidopsis development. Plant Cell (2012) 0.94
The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. Nucleic Acids Res (2010) 0.94
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Human UPF1 participates in small RNA-induced mRNA downregulation. Mol Cell Biol (2009) 0.93
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Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. PLoS One (2012) 0.90
Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. Nucleic Acids Res (2014) 0.89
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res (2014) 0.88
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife (2016) 0.88
The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA. Nucleic Acids Res (2014) 0.87
Emergence of a complex relationship between HIV-1 and the microRNA pathway. Methods Mol Biol (2009) 0.86
Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation. RNA (2011) 0.85
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet (2013) 0.85
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Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles. J Virol (2012) 0.84
When a ribosome encounters a premature termination codon. BMB Rep (2013) 0.83
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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun (2016) 0.76
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High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection. RNA (2017) 0.75
A GC-rich sequence feature in the 3' UTR directs UPF1-dependent mRNA decay in mammalian cells. Genome Res (2016) 0.75
Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae. PLoS One (2014) 0.75
Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev (2006) 8.78
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Getting to the root of miRNA-mediated gene silencing. Cell (2008) 7.17
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol (2008) 5.57
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA (2005) 5.15
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
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An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell (2011) 2.80
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Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
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REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol (2002) 2.55
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol (2004) 2.36
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett (2007) 2.22
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J (2007) 2.11
A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol (2003) 2.11
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11
A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol (2003) 2.03
An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol (2002) 1.71
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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J (2010) 1.64
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep (2005) 1.63
Complex genomic rearrangements lead to novel primate gene function. Genome Res (2005) 1.62
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RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol (2004) 1.26
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HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol (2010) 1.23
Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol (2008) 1.22
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res (2012) 1.19
Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol (2002) 1.18
GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J (2013) 1.17
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The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res (2012) 1.03
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