Getting to the root of miRNA-mediated gene silencing.

Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50

Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79

An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88

MicroRNAs and cancer: short RNAs go a long way. Cell (2009) 7.25

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57

Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol (2009) 4.38

microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J (2008) 4.24

Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98

MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91

A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res (2008) 3.58

MiRNAs and cancer. Am J Pathol (2009) 3.42

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42

Viruses, microRNAs, and host interactions. Annu Rev Microbiol (2010) 3.30

Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20

nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell (2009) 2.87

Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol Cell (2014) 2.83

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature (2013) 2.67

Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol (2010) 2.51

MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51

MicroRNAs and cardiac pathology. Nat Rev Cardiol (2009) 2.50

microRNA-34c is a novel target to treat dementias. EMBO J (2011) 2.44

Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysis. BMC Genomics (2009) 2.39

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene (2009) 2.33

Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods (2009) 2.32

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. EMBO J (2009) 2.32

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology (2009) 2.29

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29

The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28

Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol (2009) 2.20

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15

MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun (2009) 2.12

Concern Misregulation of AUXIN RESPONSE FACTOR 8 underlies the developmental abnormalities caused by three distinct viral silencing suppressors in Arabidopsis. PLoS Pathog (2011) 2.12

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11

A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10

Proinflammatory role for let-7 microRNAS in experimental asthma. J Biol Chem (2010) 2.08

MicroRNA in lung cancer. Br J Cancer (2010) 1.97

Expression of versican 3'-untranslated region modulates endogenous microRNA functions. PLoS One (2010) 1.94

Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes. Hypertension (2010) 1.94

Form, function, and regulation of ARGONAUTE proteins. Plant Cell (2010) 1.87

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps. Nat Struct Mol Biol (2009) 1.83

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res (2010) 1.81

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA (2009) 1.80

Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75

miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75

Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. J Gastroenterol (2009) 1.73

MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol (2009) 1.71

MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One (2009) 1.70

microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat Struct Mol Biol (2010) 1.66

Correlation of expression profiles between microRNAs and mRNA targets using NCI-60 data. BMC Genomics (2009) 1.66

Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection. RNA (2010) 1.66

Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res (2011) 1.64

Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res (2010) 1.64

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation. Genome Res (2013) 1.59

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57

MicroRNAs, macrocontrol: regulation of miRNA processing. RNA (2010) 1.56

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics (2014) 1.54

Vascular smooth muscle cell proliferation in restenosis. Circ Cardiovasc Interv (2011) 1.52

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression. RNA (2009) 1.50

Cellular versus viral microRNAs in host-virus interaction. Nucleic Acids Res (2008) 1.50

Functional analysis of three Arabidopsis ARGONAUTES using slicer-defective mutants. Plant Cell (2012) 1.49

MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics (2010) 1.48

Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen. Nucleic Acids Res (2011) 1.45

Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L. EMBO J (2011) 1.44

The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem (2010) 1.44

MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization. J Biol Chem (2010) 1.44

MicroRNAs: critical mediators of differentiation, development and disease. Swiss Med Wkly (2009) 1.43

Extracellular/circulating microRNAs and their potential role in cardiovascular disease. Am J Cardiovasc Dis (2011) 1.43

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res (2009) 1.42

MicroRNA: a new frontier in kidney and blood pressure research. Am J Physiol Renal Physiol (2009) 1.41

MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica (2009) 1.40

AGO1 homeostasis involves differential production of 21-nt and 22-nt miR168 species by MIR168a and MIR168b. PLoS One (2009) 1.40

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36

Retracted MicroRNA expression profiling during the life cycle of the silkworm (Bombyx mori). BMC Genomics (2009) 1.35

The code within the code: microRNAs target coding regions. Cell Cycle (2010) 1.35

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathog (2011) 1.33

microRNAs and genetic diseases. Pathogenetics (2009) 1.32

Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis. Genes Dev (2011) 1.30

Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell Mol Life Sci (2012) 1.30

Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol (2010) 1.29

MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA. Am J Transplant (2011) 1.27

Promises and challenges of MicroRNA-based treatment of multiple myeloma. Curr Cancer Drug Targets (2012) 1.26

Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects. RNA (2011) 1.26

Up-regulation of microRNA-21 correlates with lower kidney cancer survival. PLoS One (2012) 1.26

Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform. Mol Ther (2009) 1.25

miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. Blood (2009) 1.25

MicroRNA processing pathway regulates olfactory neuron morphogenesis. Curr Biol (2008) 1.25

HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis. Cell Death Differ (2011) 1.23

MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem (2010) 1.23

Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2. Mol Biol Cell (2008) 1.20

Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway. Nucleic Acids Res (2012) 1.20

p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. Nucleic Acids Res (2010) 1.19

Computational analysis of miRNA-mediated repression of translation: implications for models of translation initiation inhibition. RNA (2008) 1.17

One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor. J Biomed Biotechnol (2011) 1.14

miRNA biogenesis: biological impact in the development of cancer. Cancer Biol Ther (2014) 1.13

Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis. BMC Med Genomics (2009) 1.13

Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev (2006) 8.78

P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol (2007) 7.96

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol (2008) 5.57

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA (2005) 5.15

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol (2007) 4.90

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol (2005) 4.45

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38

Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92

Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA (2005) 3.11

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95

Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes Dev (2007) 2.86

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell (2011) 2.80

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature (2004) 2.80

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71

Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA (2005) 2.59

REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol (2002) 2.55

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA (2008) 2.54

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol (2004) 2.36

The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol (2009) 2.28

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett (2007) 2.22

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J (2007) 2.11

A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol (2003) 2.11

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA (2009) 2.11

A C-terminal silencing domain in GW182 is essential for miRNA function. RNA (2009) 2.10

Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07

The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol (2003) 2.03

The poly(A) binding protein Hfq protects RNA from RNase E and exoribonucleolytic degradation. Nucleic Acids Res (2003) 2.00

An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol (2002) 1.71

Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J (2003) 1.70

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J (2010) 1.64

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep (2005) 1.63

Complex genomic rearrangements lead to novel primate gene function. Genome Res (2005) 1.62

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A (2011) 1.56

Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev (2006) 1.51

Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet (2009) 1.46

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44

Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell (2009) 1.43

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res (2009) 1.42

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J (2011) 1.29

The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev (2013) 1.29

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol (2004) 1.26

A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol (2007) 1.23

HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol (2010) 1.23

Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol (2008) 1.22

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res (2012) 1.19

Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol (2002) 1.18

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J (2013) 1.17

CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev (2011) 1.14

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol (2012) 1.13

The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol (2013) 1.13

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep (2004) 1.09

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol (2013) 1.09

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A (2009) 1.08

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev (2010) 1.08

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res (2012) 1.07

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev (2013) 1.07

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev (2014) 1.04

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res (2012) 1.03

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA (2008) 1.02

Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol (2013) 1.02

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J (2010) 1.00

An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev (2013) 0.99

The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics (2003) 0.97

A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol (2012) 0.97

Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell (2013) 0.95

miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res (2013) 0.93

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol (2011) 0.93

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res (2014) 0.92

Staphylococcus aureus endoribonuclease III purification and properties. Methods Enzymol (2008) 0.91

NMR assignment of the Drosophila Argonaute2 PAZ domain. J Biomol NMR (2004) 0.91

RNAi: finding the elusive endonuclease. RNA (2004) 0.88

A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol (2013) 0.79

A tiny helper lightens the maternal load. Cell (2006) 0.77