Published in Mol Cell on December 10, 2010
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell (2011) 3.20
Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell (2012) 2.85
A double take on bivalent promoters. Genes Dev (2013) 2.79
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells. Mol Cell (2013) 2.13
Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell (2015) 1.79
Chromatin and transcription in yeast. Genetics (2012) 1.61
Genome-wide function of H2B ubiquitylation in promoter and genic regions. Genes Dev (2011) 1.56
Regulation of primary response genes. Mol Cell (2011) 1.56
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription. Proc Natl Acad Sci U S A (2012) 1.31
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev (2011) 1.30
Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin. Nat Struct Mol Biol (2011) 1.23
Histone H3 phosphorylation - a versatile chromatin modification for different occasions. Biochimie (2012) 1.23
Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia (2014) 1.22
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci (2012) 1.22
The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. Genes Dev (2012) 1.09
Epigenetic control of immunity. Cold Spring Harb Perspect Biol (2014) 1.05
MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase. Cancer Res (2012) 1.04
Transcription in the maintenance of centromere chromatin identity. Nucleic Acids Res (2012) 1.03
Epigenetic modifications in the pathogenesis of diabetic nephropathy. Semin Nephrol (2013) 1.02
Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes. J Biol Chem (2012) 1.02
Methylation of histone H3 on lysine 4 by the lysine methyltransferase SET1 protein is needed for normal clock gene expression. J Biol Chem (2013) 1.01
Eradication therapies for HIV Infection: time to begin again. AIDS Res Hum Retroviruses (2011) 0.99
Transcriptional regulation of Arabidopsis LEAFY COTYLEDON2 involves RLE, a cis-element that regulates trimethylation of histone H3 at lysine-27. Plant Cell (2011) 0.99
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex. EMBO J (2012) 0.98
Chromatin: receiver and quarterback for cellular signals. Cell (2013) 0.95
Sensing core histone phosphorylation - a matter of perfect timing. Biochim Biophys Acta (2014) 0.94
Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2012) 0.92
Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes Dev (2014) 0.91
Yorkie promotes transcription by recruiting a histone methyltransferase complex. Cell Rep (2014) 0.90
Identification of histone mutants that are defective for transcription-coupled nucleosome occupancy. Mol Cell Biol (2011) 0.90
Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis. PLoS Genet (2012) 0.90
Histone tails: Directing the chromatin response to DNA damage. FEBS Lett (2011) 0.90
H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress. Genome Res (2014) 0.90
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA. Mol Cell Biol (2011) 0.89
Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. J Am Chem Soc (2012) 0.88
H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast. BMC Genomics (2011) 0.88
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem (2012) 0.88
Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Mol Cell Proteomics (2011) 0.88
Genome-wide evaluation of histone methylation changes associated with leaf senescence in Arabidopsis. PLoS One (2012) 0.87
Uncoupling transcription from covalent histone modification. PLoS Genet (2014) 0.86
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription. PLoS Pathog (2014) 0.86
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. Proc Natl Acad Sci U S A (2015) 0.86
Identification of Mutant Versions of the Spt16 Histone Chaperone That Are Defective for Transcription-Coupled Nucleosome Occupancy in Saccharomyces cerevisiae. G3 (Bethesda) (2012) 0.86
Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets. Front Oncol (2014) 0.84
Characterization of histone post-translational modifications during virus infection using mass spectrometry-based proteomics. Methods (2015) 0.84
Divergence of transcriptional landscape occurs early in B cell activation. Epigenetics Chromatin (2015) 0.84
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res (2013) 0.83
Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. Alcohol Clin Exp Res (2014) 0.83
Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1. Nucleic Acids Res (2014) 0.83
Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol (2015) 0.82
Uncoupling histone turnover from transcription-associated histone H3 modifications. Nucleic Acids Res (2015) 0.81
Renal cell neoplasms contain shared tumor type-specific copy number variations. Am J Pathol (2012) 0.81
The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3. Mol Cell Proteomics (2014) 0.80
Stress-free with Rpd3: a unique chromatin complex mediates the response to oxidative stress. Mol Cell Biol (2013) 0.80
Ubiquitin and transcription: The SCF/Met4 pathway, a (protein-) complex issue. Transcription (2011) 0.80
MYC association with cancer risk and a new model of MYC-mediated repression. Cold Spring Harb Perspect Med (2014) 0.79
ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Mol Cell (2016) 0.79
ULTRAPETALA trxG genes interact with KANADI transcription factor genes to regulate Arabidopsis gynoecium patterning. Plant Cell (2014) 0.79
Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination. Epigenetics (2013) 0.78
Measuring dynamic changes in histone modifications and nucleosome density during activated transcription in budding yeast. Methods Mol Biol (2012) 0.78
The LIM domain protein nTRIP6 recruits the mediator complex to AP-1-regulated promoters. PLoS One (2014) 0.78
Higher methylation in genomic DNA indicates incomplete reprogramming in induced pluripotent stem cells. Cell Reprogram (2013) 0.78
Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II. Genetics (2014) 0.78
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. J Mass Spectrom (2013) 0.77
Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes. Mediators Inflamm (2015) 0.76
Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor γ Using Mass Spectrometry. PPAR Res (2014) 0.76
Epigenetic inheritance: a contributor to species differentiation? DNA Cell Biol (2012) 0.76
Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One (2015) 0.76
Histone modifications induced by MDV infection at early cytolytic and latency phases. BMC Genomics (2015) 0.75
Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs? PLoS Pathog (2016) 0.75
Roles of common subunits within distinct multisubunit complexes. Proc Natl Acad Sci U S A (2013) 0.75
A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene αB-crystallin. Hum Genomics (2014) 0.75
Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. Front Mol Neurosci (2015) 0.75
Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will. Curr Genet Med Rep (2016) 0.75
MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones. Epigenetics Chromatin (2017) 0.75
Kinases and chromatin structure: who regulates whom? Epigenetics (2013) 0.75
Molecular structures guide the engineering of chromatin. Nucleic Acids Res (2017) 0.75
Chromatin modifications and their function. Cell (2007) 55.98
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66
The mammalian epigenome. Cell (2007) 18.13
The complex language of chromatin regulation during transcription. Nature (2007) 16.97
The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science (2008) 16.48
Long noncoding RNA as modular scaffold of histone modification complexes. Science (2010) 15.23
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
Chromatin structure: a repeating unit of histones and DNA. Science (1974) 13.18
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27
Genome regulation by polycomb and trithorax proteins. Cell (2007) 11.96
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell (1999) 11.90
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet (2004) 11.31
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
The CBP co-activator is a histone acetyltransferase. Nature (1997) 10.91
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell (1996) 9.86
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell (1997) 8.99
Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu Rev Biochem (1998) 8.86
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell (1997) 8.72
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science (2008) 8.45
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature (1991) 8.22
Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature (1997) 7.66
Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet (2007) 7.61
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature (2002) 7.37
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell (1992) 6.26
Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (1997) 6.15
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature (2005) 5.89
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell (1985) 5.63
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity (1999) 5.50
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Cell (1992) 5.14
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell (1997) 5.07
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev (2003) 4.93
Signaling network model of chromatin. Cell (2002) 4.87
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development (2007) 4.80
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem (2007) 4.79
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75
Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature (1998) 4.68
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem (1990) 4.60
CpG islands--'a rough guide'. FEBS Lett (2009) 4.55
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49
Histone ubiquitination: triggering gene activity. Mol Cell (2008) 4.42
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
The Trithorax-like gene encodes the Drosophila GAGA factor. Nature (1994) 4.28
An operational definition of epigenetics. Genes Dev (2009) 4.26
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
RNA helicase A mediates association of CBP with RNA polymerase II. Cell (1997) 4.00
Epigenetic spreading of the Drosophila dosage compensation complex from roX RNA genes into flanking chromatin. Cell (1999) 3.85
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81
Hierarchical recruitment of polycomb group silencing complexes. Mol Cell (2004) 3.73
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell (2010) 3.70
Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science (2007) 3.69
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol Cell (2004) 3.60
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell (2009) 3.45
The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol Cell Biol (2000) 3.44
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell (1990) 3.31
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49
An operational definition of epigenetics. Genes Dev (2009) 4.26
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
The language of histone crosstalk. Cell (2010) 3.18
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89
Histone modification: cause or cog? Trends Genet (2011) 2.85
Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04
The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell (2005) 1.99
Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89
A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin. J Cell Biochem (2005) 1.88
The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78
A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res (2007) 1.77
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52
WDR5, a complexed protein. Nat Struct Mol Biol (2009) 1.51
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51
Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49
Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev (2006) 1.46
Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics (2006) 1.42
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35
dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci U S A (2002) 1.34
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol (2008) 1.32
Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. Mol Cell (2011) 1.32
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol (2010) 1.32
Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb. Cell Cycle (2006) 1.31
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A (2008) 1.30
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev (2011) 1.30
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26
Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem (2005) 1.23
Cross-talking histones: implications for the regulation of gene expression and DNA repair. Biochem Cell Biol (2005) 1.22
SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol (2013) 1.21
The JARID2-PRC2 duality. Genes Dev (2010) 1.18
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol (2009) 1.18
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol (2005) 1.15
Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proc Natl Acad Sci U S A (2011) 1.12
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. Genes Dev (2012) 1.09
Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. J Biol Chem (2004) 1.08
Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications. Methods Enzymol (2004) 1.07
The little elongation complex regulates small nuclear RNA transcription. Mol Cell (2011) 1.06
Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol (2003) 1.04
Histone demethylation by hydroxylation: chemistry in action. ACS Chem Biol (2006) 1.01
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol (2004) 1.01
Transcriptional elongation checkpoint control in development and disease. Genes Dev (2013) 0.98
SnapShot: Histone lysine methylase complexes. Cell (2012) 0.92
Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes Dev (2014) 0.91
Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Mol Cell Biol (2005) 0.90
Developmental biology. Histone cross-talk in stem cells. Science (2009) 0.88
The curious case of bivalent marks. Dev Cell (2009) 0.87
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease. Mol Cell Biol (2013) 0.87
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. Development (2013) 0.86
A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast. Mol Cell Biol (2011) 0.85
The A, B, Gs of silencing. Genes Dev (2007) 0.84
Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development. Genes Dev (2006) 0.81
Posttranslational modifications of histones by methylation. Adv Protein Chem (2004) 0.81
Structural basis for H3K4 trimethylation by yeast Set1/COMPASS. Adv Enzyme Regul (2009) 0.79
Guided by COMPASS on a journey through chromosome segregation. Nat Struct Mol Biol (2005) 0.78
Transcriptional blackjack with p21. Genes Dev (2006) 0.78
Medicine. (Poly)combing the pediatric cancer genome for answers. Science (2013) 0.77
Preparation and assay of RNA polymerase II elongation factors elongin and ELL. Methods Enzymol (2003) 0.77
A histone modifier's ill-gotten copy gains. Cell (2013) 0.76