RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B.

PubWeight™: 2.05‹?› | Rank: Top 2%

🔗 View Article (PMC 361763)

Published in Mol Cell Biol on December 01, 1991

Authors

M Jaramillo1, T E Dever, W C Merrick, N Sonenberg

Author Affiliations

1: Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Articles citing this

Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol Cell Biol (1996) 6.35

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J (1994) 4.94

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83

Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol Cell Biol (1996) 4.42

TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65

A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49

Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc Natl Acad Sci U S A (2000) 3.01

Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol Cell Biol (2000) 2.58

Negative feedback regulation of wild-type p53 biosynthesis. EMBO J (1995) 2.52

Modularity and specialization in superfamily 1 and 2 helicases. J Bacteriol (2002) 2.14

Having it both ways: transcription factors that bind DNA and RNA. Nucleic Acids Res (2002) 1.84

A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA. Mol Cell Biol (1996) 1.79

The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing. RNA (1995) 1.77

Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase. RNA (1999) 1.44

Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Mol Cell Biol (2000) 1.39

Ribosome shunting in the cauliflower mosaic virus 35S RNA leader is a special case of reinitiation of translation functioning in plant and animal systems. Genes Dev (2000) 1.30

A helicase assay based on the displacement of fluorescent, nucleic acid-binding ligands. Nucleic Acids Res (1996) 1.27

Control of start codon choice on a plant viral RNA encoding overlapping genes. Plant Cell (1993) 1.23

Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Mol Cell Biol (2009) 1.21

Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent. J Virol (2001) 1.19

Trypanosoma brucei mitochondria contain RNA helicase activity. Nucleic Acids Res (1994) 1.17

The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold. RNA (2006) 1.12

An3 mRNA encodes an RNA helicase that colocalizes with nucleoli in Xenopus oocytes in a stage-specific manner. Proc Natl Acad Sci U S A (1994) 1.06

The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA. Nucleic Acids Res (1994) 1.01

Structural and functional similarities between the central eukaryotic initiation factor (eIF)4A-binding domain of mammalian eIF4G and the eIF4A-binding domain of yeast eIF4G. Biochem J (2001) 0.99

Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression. Mol Cell Biol (1999) 0.98

Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap. J Biol Chem (2009) 0.98

Characterization of DbpA, an Escherichia coli DEAD box protein with ATP independent RNA unwinding activity. Nucleic Acids Res (1997) 0.95

Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders. Mol Cell Biol (2000) 0.95

Recognition of RNA by the p53 tumor suppressor protein in the yeast three-hybrid system. RNA (2006) 0.91

The RNA recognition motif of yeast translation initiation factor Tif3/eIF4B is required but not sufficient for RNA strand-exchange and translational activity. RNA (1998) 0.89

Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling. J Biol Chem (2010) 0.87

A novel translational regulation function for the simian virus 40 large-T antigen gene. J Virol (1995) 0.85

Regulation of interferon-dependent mRNA translation of target genes. J Interferon Cytokine Res (2014) 0.82

A novel interaction of pokeweed antiviral protein with translation initiation factors 4G and iso4G: a potential indirect mechanism to access viral RNAs. Nucleic Acids Res (2006) 0.82

Recruitment of the 40S ribosome subunit to the 3'-untranslated region (UTR) of a viral mRNA, via the eIF4 complex, facilitates cap-independent translation. J Biol Chem (2015) 0.79

Mutational Pressure in Zika Virus: Local ADAR-Editing Areas Associated with Pauses in Translation and Replication. Front Cell Infect Microbiol (2017) 0.76

Articles cited by this

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07

RNA recognition: towards identifying determinants of specificity. Trends Biochem Sci (1991) 9.03

RNA-binding proteins as developmental regulators. Genes Dev (1989) 8.78

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33

Birth of the D-E-A-D box. Nature (1989) 7.02

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. Genes Dev (1990) 6.64

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors. J Biol Chem (1985) 4.62

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J Biol Chem (1987) 4.48

DNA helicases. Annu Rev Biochem (1990) 4.46

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45

A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35

New initiation factor activity required for globin mRNA translation. J Biol Chem (1983) 4.31

RNA helicase activity associated with the human p68 protein. Nature (1989) 3.95

Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70

Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30

The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J (1988) 3.17

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle. Trends Biochem Sci (1988) 3.17

The regulation of initiation of mammalian protein synthesis. Prog Nucleic Acid Res Mol Biol (1981) 2.81

The ATP-dependent interaction of eukaryotic initiation factors with mRNA. J Biol Chem (1987) 2.65

An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. Nature (1988) 2.55

RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem (1984) 2.49

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. EMBO J (1990) 2.12

Simian virus 40 large T antigen DNA helicase. Characterization of the ATPase-dependent DNA unwinding activity and its substrate requirements. J Biol Chem (1988) 2.10

Poliovirus translation. Curr Top Microbiol Immunol (1990) 2.06

Dissociation of double-stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay. Biochemistry (1989) 1.87

A cellular 57 kDa protein binds to two regions of the internal translation initiation site of foot-and-mouth disease virus. FEBS Lett (1990) 1.78

Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA. J Biol Chem (1988) 1.71

Characterization of the 46,000-dalton subunit of eIF-4F. Arch Biochem Biophys (1990) 1.46

Recycling of messenger RNA cap-binding proteins mediated by eukaryotic initiation factor 4B. J Biol Chem (1986) 0.90

Articles by these authors

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (1988) 19.07

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59

Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14

Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J Biol Chem (1982) 7.82

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature (1990) 7.74

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev (1998) 6.89

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89

PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (1994) 5.62

Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology (1997) 5.26

A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J (1998) 5.18

GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A (1987) 5.16

Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J (1994) 4.94

Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J (1995) 4.83

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75

mTOR, translation initiation and cancer. Oncogene (2006) 4.68

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors. J Biol Chem (1985) 4.62

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37

A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev (1989) 4.35

New initiation factor activity required for globin mRNA translation. J Biol Chem (1983) 4.31

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med (2001) 4.19

Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08

The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature (2000) 4.01

TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85

Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell (1999) 3.76

Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70

mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65

Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55

A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49

The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol (1993) 3.48

RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36

Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation. Prog Nucleic Acid Res Mol Biol (1988) 3.30

Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21

The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09

Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07

Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A. J Biol Chem (1999) 2.99

Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc Natl Acad Sci U S A (1998) 2.93

A cell cycle-dependent internal ribosome entry site. Mol Cell (2000) 2.91

Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89

A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell (2000) 2.83

Cap-dependent RNA splicing in a HeLa nuclear extract. Proc Natl Acad Sci U S A (1985) 2.82

Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81

Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA. Nature (1985) 2.80

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75

Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73

eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure. J Biol Chem (1997) 2.70

A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol (1997) 2.66

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65

The ATP-dependent interaction of eukaryotic initiation factors with mRNA. J Biol Chem (1987) 2.65

Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation. EMBO J (1988) 2.65

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol (2001) 2.64

mTOR signaling to translation. Curr Top Microbiol Immunol (2004) 2.62

Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55

Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. J Biol Chem (2001) 2.53

Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Science (1988) 2.53

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53

Translational repression by a novel partner of human poly(A) binding protein, Paip2. Mol Cell (2001) 2.49

High-level synthesis in Escherichia coli of functional cap-binding eukaryotic initiation factor eIF-4E and affinity purification using a simplified cap-analog resin. Gene (1988) 2.49

RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem (1984) 2.49

Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A (1996) 2.47

Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1980) 2.46

Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition. J Biol Chem (1992) 2.44

A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40

A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37

Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem (1987) 2.36

Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J Virol (1989) 2.36

A new pathway of translational regulation mediated by eukaryotic initiation factor 3. EMBO J (2000) 2.32

Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J Virol (1994) 2.30

Eukaryotic protein elongation factors. Trends Biochem Sci (1990) 2.27

Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain. Mol Cell Biol (1998) 2.21