Accelerated wound closure in mice deficient for interleukin-10.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1762712)

Published in Am J Pathol on January 01, 2007

Authors

Sabine A Eming1, Sabine Werner, Philippe Bugnon, Claudia Wickenhauser, Lisa Siewe, Olaf Utermöhlen, Jeffrey M Davidson, Thomas Krieg, Axel Roers

Author Affiliations

1: Department of Dermatology, University of Cologne, Joseph-Stelzmann Str. 9, 50931 Köln, Germany. sabine.eming@uni-koeln.de

Articles citing this

Innate immunity and its regulation by mast cells. J Immunol (2013) 1.19

Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood (2013) 0.90

Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice. BMC Immunol (2009) 0.88

Regenerative Wound Healing: The Role of Interleukin-10. Adv Wound Care (New Rochelle) (2014) 0.85

CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. Am J Pathol (2009) 0.84

Wound healing and antibacterial properties of methanolic extract of Pupalia lappacea Juss in rats. BMC Complement Altern Med (2014) 0.83

Wound healing in development. Birth Defects Res C Embryo Today (2012) 0.83

Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med (2014) 0.83

Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A (2013) 0.82

Understanding the host response to cell-laden poly(ethylene glycol)-based hydrogels. Biomaterials (2012) 0.80

Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses. Alcohol Clin Exp Res (2014) 0.79

Using an Agent-Based Model to Examine the Role of Dynamic Bacterial Virulence Potential in the Pathogenesis of Surgical Site Infection. Adv Wound Care (New Rochelle) (2013) 0.79

Accelerated wound healing phenotype in Interleukin 12/23 deficient mice. J Inflamm (Lond) (2011) 0.78

The molecular basis of hypertrophic scars. Burns Trauma (2016) 0.78

The Influence of Bone Marrow-Secreted IL-10 in a Mouse Model of Cerulein-Induced Pancreatic Fibrosis. Biomed Res Int (2016) 0.77

The role of interleukin-10 and hyaluronan in murine fetal fibroblast function in vitro: implications for recapitulating fetal regenerative wound healing. PLoS One (2015) 0.77

Efficacy of Acorus calamus on collagen maturation on full thickness cutaneous wounds in rats. Pharmacogn Mag (2014) 0.77

Modulatory effect of whey proteins in some cytokines involved in wound healing in male diabetic albino rats. Inflammation (2014) 0.76

The multicomponent medication lymphomyosot improves the outcome of experimental lymphedema. Lymphat Res Biol (2013) 0.76

Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing. Exp Toxicol Pathol (2011) 0.75

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging. Int J Mol Sci (2017) 0.75

Rapid tissue regeneration induced by intracellular ATP delivery-A preliminary mechanistic study. PLoS One (2017) 0.75

Diabetic Wounds Exhibit Decreased Ym1 and Arginase Expression with Increased Expression of IL-17 and IL-20. Adv Wound Care (New Rochelle) (2016) 0.75

VEGF released by deferoxamine preconditioned mesenchymal stem cells seeded on collagen-GAG substrates enhances neovascularization. Sci Rep (2016) 0.75

A systematic and quantitative method for wound-dressing evaluation. Burns Trauma (2015) 0.75

HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms. Int J Mol Sci (2016) 0.75

Articles cited by this

Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53

Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science (1993) 14.91

Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol (2002) 14.80

IL-10 inhibits cytokine production by activated macrophages. J Immunol (1991) 13.13

Regulation of wound healing by growth factors and cytokines. Physiol Rev (2003) 9.82

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med (1992) 8.46

Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A (1987) 6.76

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol (1975) 6.42

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol (1996) 5.79

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58

Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol (2007) 5.16

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol (2002) 3.89

Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun (1998) 3.80

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43

Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol (2003) 2.87

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med (2000) 2.48

Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunol Lett (2003) 2.42

Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice. Am J Pathol (2001) 2.34

Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J (2000) 1.99

The neutrophilic leukocyte in wound repair a study with antineutrophil serum. J Clin Invest (1972) 1.96

Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3. Scand J Immunol (2001) 1.86

Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med (2003) 1.81

Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. FASEB J (2002) 1.76

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med (1995) 1.68

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol (2006) 1.51

Role of endothelial selectins in wound repair. Am J Pathol (1997) 1.50

Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. J Pediatr Surg (2000) 1.47

Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis. J Infect Dis (2001) 1.46

The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. J Immunol (2004) 1.42

Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol (2000) 1.40

Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts. J Clin Invest (1994) 1.28

Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo. Am J Physiol Lung Cell Mol Physiol (2000) 1.23

Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J (2005) 1.22

Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis. Infect Immun (2001) 1.22

Impairment of skin wound healing in beta-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol (2004) 1.21

Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine. Proc Assoc Am Physicians (1998) 1.19

Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing. Biochem Biophys Res Commun (1999) 1.19

Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes. J Immunol (1997) 0.99

Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem (2003) 0.99

Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1. Biochem Biophys Res Commun (2001) 0.96

Interleukin-10 suppresses proliferation and remodeling of extracellular matrix of cultured human skin fibroblasts. Eur Surg Res (2004) 0.82

Collagen metabolism. Methods Enzymol (1988) 0.79

Articles by these authors

Wound repair and regeneration. Nature (2008) 12.30

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82

Scleroderma. N Engl J Med (2009) 6.50

Active caspase-1 is a regulator of unconventional protein secretion. Cell (2008) 5.89

Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol (2007) 5.16

Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol (2008) 4.05

Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56

Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol (2007) 3.51

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol (2004) 2.94

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58

The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol (2007) 2.57

Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood (2012) 2.43

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32

ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol (2005) 2.31

Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology (2010) 2.17

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature (2013) 2.13

Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol (2003) 2.05

Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis. J Allergy Clin Immunol (2013) 2.04

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04

SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol (2003) 1.98

c-Met is essential for wound healing in the skin. J Cell Biol (2007) 1.98

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol Cell Biol (2002) 1.97

Editorial ethical guidelines: what about the evaluation of the benefits to humans? Lab Anim (2012) 1.92

Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers. Chem Biol (2007) 1.89

Oxidative stress in normal and impaired wound repair. Pharmacol Res (2008) 1.80

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A (2004) 1.80

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood (2013) 1.79

The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A (2008) 1.77

Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J (2007) 1.76

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet (2005) 1.74

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis. Hepatology (2014) 1.73

The human papillomavirus type 8 E2 protein induces skin tumors in transgenic mice. J Invest Dermatol (2008) 1.71

MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood (2004) 1.71

Attenuation of allergic contact dermatitis through the endocannabinoid system. Science (2007) 1.70

Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest (2006) 1.65

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell (2004) 1.65

Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol (2003) 1.63

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. J Exp Med (2012) 1.62

Dynamic reciprocity in the wound microenvironment. Wound Repair Regen (2011) 1.62

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature (2009) 1.62

An important role of lymphatic vessel activation in limiting acute inflammation. Blood (2011) 1.62

Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity (2013) 1.62

Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) 1.60

Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J Clin Invest (2006) 1.58

Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest (2012) 1.58

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol (2011) 1.56

Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. J Invest Dermatol (2006) 1.54

New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep (2007) 1.54

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol (2006) 1.51

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol (2011) 1.49

Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition. Blood (2006) 1.47

Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice. Mol Cell Biol (2005) 1.46

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J (2007) 1.45

Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest (2002) 1.45

ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem (2005) 1.45

Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis (2009) 1.45

Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing. Mol Cell Biol (2006) 1.45

Transcriptional control of wound repair. Annu Rev Cell Dev Biol (2007) 1.44

Wound-healing studies in transgenic and knockout mice. Mol Biotechnol (2004) 1.43

Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol (2006) 1.43

Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression. Antimicrob Agents Chemother (2004) 1.43

Interrelation of immunity and tissue repair or regeneration. Semin Cell Dev Biol (2009) 1.42

A2b adenosine receptors in cardioprotection: timing is everything. J Mol Cell Cardiol (2010) 1.41

Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39

Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L. Leuk Lymphoma (2006) 1.39

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39

Mast cell-specific Cre/loxP-mediated recombination in vivo. Transgenic Res (2007) 1.36

Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med (2012) 1.35

Murine model of the Ehlers-Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages. J Biol Chem (2006) 1.35

Aldara activates TLR7-independent immune defence. Nat Commun (2013) 1.34

Keloids--clinical diagnosis, pathogenesis, and treatment options. J Dtsch Dermatol Ges (2004) 1.34

Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo. Blood (2003) 1.32

Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression. J Invest Dermatol (2006) 1.32

Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol (2004) 1.30

NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol (2004) 1.29

TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol (2010) 1.29

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep (2013) 1.28

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest (2008) 1.27