Published in Autophagy on March 30, 2007
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Autophagy and aging: keeping that old broom working. Trends Genet (2008) 3.09
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol (2011) 2.55
Can autophagy promote longevity? Nat Cell Biol (2010) 2.55
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY) (2009) 2.45
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A (2009) 2.21
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The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol (2008) 1.86
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev (2007) 1.85
Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84
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Autophagy in cellular growth control. FEBS Lett (2010) 1.74
Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J (2011) 1.66
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
Lessons from C. elegans: signaling pathways for longevity. Trends Endocrinol Metab (2012) 1.54
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res (2012) 1.53
Converging pathways in lifespan regulation. Curr Biol (2009) 1.48
Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun (2013) 1.46
Emerging role of autophagy in kidney function, diseases and aging. Autophagy (2012) 1.43
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun (2013) 1.42
Why sick cells produce tumors: the protective role of autophagy. Autophagy (2007) 1.34
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell (2009) 1.31
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol (2012) 1.25
TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ (2008) 1.23
The regulation of aging: does autophagy underlie longevity? Trends Cell Biol (2009) 1.22
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr) (2011) 1.17
Autophagy takes flight in Drosophila. FEBS Lett (2010) 1.15
Molecular time-course and the metabolic basis of entry into dauer in Caenorhabditis elegans. PLoS One (2009) 1.13
Mechanisms underlying the neuroprotective effect of brain reserve against late life depression. J Neural Transm (Vienna) (2014) 1.07
Autophagy - An Emerging Anti-Aging Mechanism. J Clin Exp Pathol (2012) 1.01
Autophagy and cardiovascular aging: lesson learned from rapamycin. Cell Cycle (2012) 1.00
Transcriptional and epigenetic regulation of autophagy in aging. Autophagy (2015) 0.97
Cardiomyocyte autophagy: remodeling, repairing, and reconstructing the heart. Curr Hypertens Rep (2009) 0.95
Caenorhabditis elegans 2007: the premier model for the study of aging. Exp Gerontol (2007) 0.94
Autophagy genes are required for normal lipid levels in C. elegans. Autophagy (2013) 0.93
Macroautophagy: the key ingredient to a healthy diet? Autophagy (2009) 0.92
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci (2014) 0.91
Guidelines for monitoring autophagy in Caenorhabditis elegans. Autophagy (2015) 0.91
Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem (2015) 0.87
Targeting the autophagy pathway for cancer chemoprevention. Curr Opin Cell Biol (2010) 0.87
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J (2009) 0.87
Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans. Genes Dev (2017) 0.85
Does autophagy take a front seat in lifespan extension? J Cell Mol Med (2010) 0.85
Immunostimulatory activity of lifespan-extending agents. Aging (Albany NY) (2013) 0.85
C. elegans as a model for membrane traffic. WormBook (2014) 0.84
Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. PLoS One (2013) 0.84
The Nematode Caenorhabditis elegans, Stress and Aging: Identifying the Complex Interplay of Genetic Pathways Following the Treatment with Humic Substances. Front Genet (2012) 0.83
Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. J Biomed Sci (2012) 0.82
Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease. Neurotherapeutics (2015) 0.80
Paraplegia increases skeletal muscle autophagy. Muscle Nerve (2012) 0.76
Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant. J Gerontol A Biol Sci Med Sci (2016) 0.76
Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans. Autophagy (2016) 0.76
Detection of Autophagy in Caenorhabditis elegans Using GFP::LGG-1 as an Autophagy Marker. Cold Spring Harb Protoc (2016) 0.76
Mechanisms of aging-related proteinopathies in Caenorhabditis elegans. Exp Mol Med (2016) 0.75
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol (2016) 0.75
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. Aging Cell (2017) 0.75
TOR-mediated regulation of metabolism in aging. Aging Cell (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Genomic analysis of mouse retinal development. PLoS Biol (2004) 4.66
Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet (2005) 4.33
Reduced lopinavir exposure during pregnancy. AIDS (2006) 3.98
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A (2009) 3.41
Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med (2012) 3.20
The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains. Autophagy (2007) 3.14
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. Bioorg Med Chem (2003) 3.13
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today (2006) 2.59
QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations. Bioinformatics (2008) 2.57
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. Cell (2006) 2.28
Using heteroskedasticity-consistent standard error estimators in OLS regression: an introduction and software implementation. Behav Res Methods (2007) 2.27
TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20
Pooling data from multiple longitudinal studies: the role of item response theory in integrative data analysis. Dev Psychol (2008) 2.00
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One (2008) 1.94
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A (2007) 1.92
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res (2006) 1.89
Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res (2007) 1.83
Autophagy and the degradation of mitochondria. Mitochondrion (2010) 1.75
Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy (2009) 1.72
Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol (2006) 1.70
Testing differences between nested covariance structure models: Power analysis and null hypotheses. Psychol Methods (2006) 1.70
Retroperitoneal composite pheochromocytoma-ganglioneuroma : a case report and review of literature. Diagn Pathol (2013) 1.67
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J Biol Chem (2004) 1.66
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer. Lung Cancer (2012) 1.66
Lopinavir exposure with an increased dose during pregnancy. J Acquir Immune Defic Syndr (2008) 1.65
Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem (2004) 1.63
TRPM7 is essential for Mg(2+) homeostasis in mammals. Nat Commun (2010) 1.60
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res (2006) 1.59
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis (2005) 1.59
The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem (2005) 1.50
The social ecology of adolescent alcohol misuse. Child Dev (2008) 1.49
Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition. Clin Chem Lab Med (2011) 1.48
Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. J Biol Chem (2003) 1.47
MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells. Int J Oncol (2012) 1.46
Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol (2004) 1.46
Peer smoking, other peer attributes, and adolescent cigarette smoking: a social network analysis. Prev Sci (2008) 1.44
Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci (2013) 1.43
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. Nat Chem Biol (2010) 1.41
A protease pathway for the repair of topoisomerase II-DNA covalent complexes. J Biol Chem (2006) 1.41
Waist Circumference is Better Than Other Anthropometric Indices for Predicting Cardiovascular Disease Risk Factors in Chinese Children-a Cross-Sectional Study in Guangzhou. J Atheroscler Thromb (2015) 1.40
A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Proc Natl Acad Sci U S A (2005) 1.37
Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. J Acquir Immune Defic Syndr (2010) 1.33
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. J Mol Biol (2008) 1.32
A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. J Biol Chem (2008) 1.31
Toward a more systematic assessment of smoking: development of a smoking module for PROMIS®. Addict Behav (2012) 1.27
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. Cancer Res (2003) 1.26
Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J Acquir Immune Defic Syndr (2011) 1.24
Increased serum cathepsin S in patients with atherosclerosis and diabetes. Atherosclerosis (2005) 1.24
Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet (2010) 1.24
Attributable risk function in the proportional hazards model for censored time-to-event. Biostatistics (2006) 1.23
Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol Biol Cell (2002) 1.23
Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro. J Biol Chem (2006) 1.23
Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. Am J Hum Genet (2011) 1.23
Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol (2002) 1.20
ISG15 as a novel tumor biomarker for drug sensitivity. Mol Cancer Ther (2008) 1.19
The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.18
Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death. J Biol Chem (2003) 1.17
Enzymatic route to preparative-scale synthesis of UDP-GlcNAc/GalNAc, their analogues and GDP-fucose. Nat Protoc (2010) 1.15
DNA damage-mediated apoptosis induced by selenium compounds. J Biol Chem (2003) 1.15
G-quadruplexes induce apoptosis in tumor cells. Cancer Res (2006) 1.14
Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. AIDS (2008) 1.13
A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer. Mol Pharmacol (2010) 1.12
Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks. J Biol Chem (2009) 1.11
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development (2004) 1.11
Preliminary experience of fast-track surgery combined with laparoscopy-assisted radical distal gastrectomy for gastric cancer. J Gastrointest Surg (2012) 1.11
Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells. PLoS One (2012) 1.09
Efficacy of SSH PCR in isolating differentially expressed genes. BMC Genomics (2002) 1.09
Directly observed therapy (DOT) for nonadherent HIV-infected youth: lessons learned, challenges ahead. AIDS Res Hum Retroviruses (2010) 1.08
Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res (2013) 1.08
Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast. J Biol Chem (2003) 1.08
Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics (2007) 1.08
A social contextual analysis of youth cigarette smoking development. Nicotine Tob Res (2010) 1.07
The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC. FEBS Lett (2008) 1.07
Reconstruction of the corneal epithelium with induced marrow mesenchymal stem cells in rats. Mol Vis (2010) 1.07
Nuclear translocation of cytochrome c during apoptosis. J Biol Chem (2004) 1.06
Angiotensin II type 1 receptor antagonists inhibit cell proliferation and angiogenesis in breast cancer. Cancer Lett (2012) 1.06
Regulation of elongation factor-2 kinase by pH. Biochemistry (2002) 1.05
Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem (2003) 1.05