Published in FEBS Lett on January 13, 2010
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Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59
WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Dev Cell (2016) 1.40
RNA-seq analyses of blood-induced changes in gene expression in the mosquito vector species, Aedes aegypti. BMC Genomics (2011) 1.24
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet (2012) 1.21
The incredible ULKs. Cell Commun Signal (2012) 1.12
Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. PLoS Genet (2013) 1.07
Drosophila as a model system to study autophagy. Semin Immunopathol (2010) 0.99
Intracellular recognition of pathogens and autophagy as an innate immune host defence. J Biochem (2011) 0.95
Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell Cycle (2013) 0.95
20-Hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body. Autophagy (2013) 0.93
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy (2013) 0.93
The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis. BMC Dev Biol (2012) 0.90
Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila. Dis Model Mech (2011) 0.89
Transcriptome of the adult female malaria mosquito vector Anopheles albimanus. BMC Genomics (2012) 0.88
Antimicrobial autophagy: a conserved innate immune response in Drosophila. J Innate Immun (2013) 0.85
Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles. Dev Biol (2013) 0.82
A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster. G3 (Bethesda) (2013) 0.82
Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. J Biomed Sci (2012) 0.82
Nutritional Control of Insect Reproduction. Curr Opin Insect Sci (2015) 0.79
Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster. BMC Genomics (2016) 0.79
Melipona quadrifasciata (Hymenoptera: Apidae) fat body persists through metamorphosis with a few apoptotic cells and an increased autophagy. Protoplasma (2014) 0.79
Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. PLoS One (2014) 0.79
Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model. Dis Model Mech (2015) 0.78
Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster. PLoS One (2015) 0.78
Distinct requirements of Autophagy-related genes in programmed cell death. Cell Death Differ (2015) 0.78
Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol (2016) 0.76
Nucleolar stress in Drosophila melanogaster: RNAi-mediated depletion of Nopp140. Nucleus (2013) 0.75
Apoptosis-related genes control autophagy and influence DENV-2 infection in the mosquito vector, Aedes aegypti. Insect Biochem Mol Biol (2016) 0.75
Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise? Fly (Austin) (2013) 0.75
A HOPS Protein, MoVps41, Is Crucially Important for Vacuolar Morphogenesis, Vegetative Growth, Reproduction and Virulence in Magnaporthe oryzae. Front Plant Sci (2017) 0.75
Starvation Promotes Autophagy-Associated Maturation of the Ovary in the Giant Freshwater Prawn, Macrobrachium rosenbergii. Front Physiol (2017) 0.75
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett (1993) 13.48
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24
Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell (2004) 8.53
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
Toxic proteins in neurodegenerative disease. Science (2002) 5.82
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol (2008) 5.52
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell (2005) 4.64
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem (2007) 4.33
An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell (2009) 4.07
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev (2007) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Steroid regulation of autophagic programmed cell death during development. Development (2001) 2.68
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy (2009) 2.43
Autophagy regulates ageing in C. elegans. Autophagy (2007) 2.22
Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20
Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules. J Cell Sci (2005) 2.08
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J Cell Biol (2008) 2.02
Roles of ecdysone in Drosophila development. Proc Natl Acad Sci U S A (1977) 1.83
Steroid regulation of midgut cell death during Drosophila development. Dev Biol (2002) 1.67
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet (2007) 1.66
Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ (2007) 1.58
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling. Apoptosis (2009) 1.43
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Genes Dev (2008) 1.40
How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. PLoS One (2009) 1.26
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev (2009) 1.18
The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants. Mol Genet Genomics (2001) 1.10
Autophagy promotes caspase-dependent cell death during Drosophila development. Autophagy (2009) 1.09
A novel role for the Drosophila epsin (lqf): involvement in autophagy. Autophagy (2009) 0.89
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell (2004) 8.53
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45
An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell (2009) 4.07
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol (2013) 3.88
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev (2007) 3.18
Autophagy: a forty-year search for a missing membrane source. PLoS Biol (2006) 2.64
TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol (2006) 2.24
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem Soc Trans (2009) 1.91
The Hedgehog signalling pathway regulates autophagy. Nat Commun (2012) 1.80
Thinking globally and acting locally with TOR. Curr Opin Cell Biol (2006) 1.79
The cell biology of autophagy in metazoans: a developing story. Development (2008) 1.76
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One (2009) 1.61
Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem (2010) 1.60
Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis (2002) 1.54
Drosophila target of rapamycin kinase functions as a multimer. Genetics (2005) 1.50
Experimental control and characterization of autophagy in Drosophila. Methods Mol Biol (2008) 1.27
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. PLoS One (2009) 1.26
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. J Cell Biol (2013) 1.26
Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One (2007) 1.23
Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis. Autophagy (2008) 0.93
The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics (2005) 0.89
Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS One (2012) 0.82
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. Autophagy (2015) 0.82