Published in J Biol Chem on May 03, 2007
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A (2010) 1.85
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71
Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron (2010) 1.66
The CatSper channel: a polymodal chemosensor in human sperm. EMBO J (2012) 1.40
Advances in male contraception. Endocr Rev (2008) 1.39
The role of Hv1 and CatSper channels in sperm activation. J Physiol (2010) 1.33
Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab (2010) 1.30
Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol (2008) 1.23
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A (2011) 1.22
Ion channels, phosphorylation and mammalian sperm capacitation. Asian J Androl (2011) 1.21
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun (2011) 1.16
A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod (2009) 1.10
Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A (2013) 1.05
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One (2008) 1.05
Rediscovering sperm ion channels with the patch-clamp technique. Mol Hum Reprod (2011) 1.03
Comparative analysis of testis protein evolution in rodents. Genetics (2008) 1.02
Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels. Biol Reprod (2009) 0.99
Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell (2014) 0.98
Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One (2009) 0.97
The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent. Reprod Biol Endocrinol (2009) 0.96
Central role of soluble adenylyl cyclase and cAMP in sperm physiology. Biochim Biophys Acta (2014) 0.94
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol (2013) 0.92
ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A (2011) 0.91
SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proc Natl Acad Sci U S A (2015) 0.90
Mathematical modeling of calcium signaling during sperm hyperactivation. Mol Hum Reprod (2011) 0.86
Sperm patch-clamp. Methods Enzymol (2013) 0.85
Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition. J Biol Chem (2010) 0.84
The CatSper channel controls chemosensation in sea urchin sperm. EMBO J (2014) 0.83
Structural and regulatory evolution of cellular electrophysiological systems. Evol Dev (2009) 0.83
Calcium influx and male fertility in the context of the sperm proteome: an update. Biomed Res Int (2014) 0.81
The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition. Asian J Androl (2015) 0.78
The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon's head to tail. Cell Death Dis (2016) 0.75
CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Elife (2017) 0.75
Progress in ciliary ion channel physiology. J Gen Physiol (2016) 0.75
The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol (2015) 0.75
Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs. Reprod Biol Endocrinol (2011) 0.75
In silico determination of the effect of multi-target drugs on calcium dynamics signaling network underlying sea urchin spermatozoa motility. PLoS One (2014) 0.75
Male contraception. Indian J Endocrinol Metab (2012) 0.75
The Catsper channel and its roles in male fertility: a systematic review. Reprod Biol Endocrinol (2017) 0.75
Distinct sets of genetic alterations in melanoma. N Engl J Med (2005) 17.26
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (2009) 3.96
The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63
TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature (2006) 2.63
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron (2003) 2.61
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A (2007) 2.59
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell (2007) 2.54
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron (2006) 2.50
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res (2005) 2.40
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem (2003) 2.29
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci (2005) 2.09
Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage. Sci Signal (2012) 2.07
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron (2004) 1.97
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol (2002) 1.94
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A (2007) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res (2010) 1.74
Essential role for TRPC5 in amygdala function and fear-related behavior. Cell (2009) 1.72
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71
Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron (2010) 1.66
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A (2009) 1.60
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Rheotaxis guides mammalian sperm. Curr Biol (2013) 1.47
Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J (2003) 1.46
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci (2012) 1.45
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci (2009) 1.41
MCU encodes the pore conducting mitochondrial calcium currents. Elife (2013) 1.39
In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway. FEBS Lett (2005) 1.37
The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks. Bioessays (2008) 1.37
CACNA1H mutations in autism spectrum disorders. J Biol Chem (2006) 1.35
Lysosomal physiology. Annu Rev Physiol (2015) 1.34
Coupled feedback loops form dynamic motifs of cellular networks. Biophys J (2007) 1.32
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A (2004) 1.28
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics. Bioinformatics (2008) 1.26
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol (2004) 1.26
Modeling and simulation of intracellular dynamics: choosing an appropriate framework. IEEE Trans Nanobioscience (2004) 1.25
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A (2013) 1.25
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J (2006) 1.25
CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Biol Reprod (2007) 1.24
Coupled positive and negative feedback circuits form an essential building block of cellular signaling pathways. Bioessays (2007) 1.24
Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell (2012) 1.23
Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol (2008) 1.23
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol (2003) 1.23
Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A (2011) 1.19
Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun (2013) 1.19
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A (2008) 1.17
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun (2011) 1.16
Possible interethnic differences in quinidine-induced QT prolongation between healthy Caucasian and Korean subjects. Br J Clin Pharmacol (2006) 1.16
Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell (2003) 1.15
Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem (2006) 1.14
Coherent coupling of feedback loops: a design principle of cell signaling networks. Bioinformatics (2008) 1.14
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A (2011) 1.12
Inferring gene regulatory networks from temporal expression profiles under time-delay and noise. Comput Biol Chem (2007) 1.12
Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol (2011) 1.12
Identification of small scale biochemical networks based on general type system perturbations. FEBS J (2005) 1.11
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A (2013) 1.10
A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod (2009) 1.10
Optimal sampling time selection for parameter estimation in dynamic pathway modeling. Biosystems (2004) 1.08
TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol (2005) 1.07
Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell (2012) 1.07
The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises. Comput Biol Chem (2006) 1.06
Calcium signaling through CatSper channels in mammalian fertilization. Physiology (Bethesda) (2010) 1.06
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One (2008) 1.05
Identification of biochemical networks by S-tree based genetic programming. Bioinformatics (2006) 1.05