Published in J Biol Chem on July 11, 2003
TRP channels. Annu Rev Biochem (2007) 8.09
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest (2006) 2.74
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Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol (2006) 2.56
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch (2007) 2.17
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12
TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04
Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol (2004) 2.03
TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem (2006) 1.90
Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron (2015) 1.69
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
Multiple roles of calmodulin and other Ca(2+)-binding proteins in the functional regulation of TRP channels. Pflugers Arch (2005) 1.68
TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc Natl Acad Sci U S A (2010) 1.66
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A (2009) 1.66
TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res (2010) 1.65
Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci (2010) 1.63
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
TRPC1: store-operated channel and more. Pflugers Arch (2005) 1.47
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci (2009) 1.38
Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells. J Physiol (2007) 1.37
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
Physiological mechanisms of TRPC activation. Pflugers Arch (2005) 1.31
Calcium-sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth. J Physiol (2006) 1.29
Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clin Exp Pharmacol Physiol (2008) 1.29
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol (2005) 1.28
Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch (2005) 1.24
Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol (2005) 1.22
A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Genetics (2006) 1.22
TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am J Physiol Cell Physiol (2009) 1.21
Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes. J Physiol (2008) 1.20
TRPC Channels Mediate a Muscarinic Receptor-Induced Afterdepolarization in Cerebral Cortex. J Neurosci (2009) 1.17
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1. Hum Mol Genet (2009) 1.17
Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Mol Biol Cell (2008) 1.17
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.15
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
Store-operated calcium entry in vascular smooth muscle. Br J Pharmacol (2007) 1.11
Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol (2011) 1.11
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem (2011) 1.05
TRPpathies. J Physiol (2006) 1.04
TRPing on the lung endothelium: calcium channels that regulate barrier function. Antioxid Redox Signal (2009) 1.04
Inhibition of TRPC1/TRPC3 by PKG contributes to NO-mediated vasorelaxation. Am J Physiol Heart Circ Physiol (2009) 1.04
Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr (2013) 1.03
C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. J Physiol (2007) 1.03
TRPC channel lipid specificity and mechanisms of lipid regulation. Cell Calcium (2009) 1.03
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Roles of TRP channels in the development of cardiac hypertrophy. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.02
Organization and function of TRPC channelosomes. Pflugers Arch (2007) 1.01
TRP channels and mice deficient in TRP channels. Pflugers Arch (2005) 1.00
Calcium regulates podocyte actin dynamics. Semin Nephrol (2012) 0.98
Role of TRPM in melanocytes and melanoma. Exp Dermatol (2012) 0.98
TRPC channels and their implication in neurological diseases. CNS Neurol Disord Drug Targets (2010) 0.97
Protein-protein interaction and functionTRPC channels. Pflugers Arch (2005) 0.97
Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte. J Physiol (2006) 0.96
Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci (2013) 0.95
Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.94
A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling. J Physiol (2011) 0.94
The trinity of Ca2+ sources for the exocytotic glutamate release from astrocytes. Neurochem Int (2009) 0.94
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J Biol Chem (2010) 0.94
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. Hippocampus (2012) 0.93
Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels. J Neurophysiol (2011) 0.93
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circ Res (2012) 0.91
Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell (2010) 0.90
Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res (2012) 0.90
TRP-ing up heart and vessels: canonical transient receptor potential channels and cardiovascular disease. J Cardiovasc Transl Res (2010) 0.89
Structure-function analysis of TRPV channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.89
Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol (2014) 0.88
Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system. J Comp Neurol (2008) 0.88
Mechanism and functional significance of TRPC channel multimerization. Semin Cell Dev Biol (2006) 0.87
Emerging roles of canonical TRP channels in neuronal function. Adv Exp Med Biol (2011) 0.87
Neural cell adhesion molecule induces intracellular signaling via multiple mechanisms of Ca2+ homeostasis. Mol Biol Cell (2006) 0.87
Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx. J Biol Chem (2012) 0.87
Integration of transient receptor potential canonical channels with lipids. Acta Physiol (Oxf) (2011) 0.86
STIM and ORAI proteins in the nervous system. Channels (Austin) (2015) 0.85
Evidence that TRPC4 supports the calcium selective I(CRAC)-like current in human gingival keratinocytes. Pflugers Arch (2006) 0.85
A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. PLoS One (2010) 0.85
TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.84
Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. J Neurosci (2011) 0.84
Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels. Pflugers Arch (2013) 0.83
Transient receptor potential channels and regulation of lung endothelial permeability. Pulm Circ (2013) 0.82
Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch (2014) 0.82
Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus. J Neurosci (2014) 0.82
Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? Cells (2014) 0.82
Redox regulation of endothelial canonical transient receptor potential channels. Antioxid Redox Signal (2011) 0.82
Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Arch (2010) 0.82
TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nat Commun (2016) 0.81
Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity. Pflugers Arch (2014) 0.81
Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.81
Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol (2014) 0.81
A network perspective on unraveling the role of TRP channels in biology and disease. Pflugers Arch (2013) 0.81
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (2009) 3.96
The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63
TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature (2006) 2.63
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron (2003) 2.61
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A (2007) 2.59
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron (2006) 2.50
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res (2005) 2.40
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci (2005) 2.09
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron (2004) 1.97
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol (2002) 1.94
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A (2007) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
Essential role for TRPC5 in amygdala function and fear-related behavior. Cell (2009) 1.72
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A (2009) 1.60
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Rheotaxis guides mammalian sperm. Curr Biol (2013) 1.47
Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J (2003) 1.46
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci (2012) 1.45
CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem (2007) 1.43
MCU encodes the pore conducting mitochondrial calcium currents. Elife (2013) 1.39
CACNA1H mutations in autism spectrum disorders. J Biol Chem (2006) 1.35
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A (2004) 1.28
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol (2004) 1.26
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A (2013) 1.25
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J (2006) 1.25
Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol (2008) 1.23
Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A (2011) 1.19
Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun (2013) 1.19
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A (2008) 1.17
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun (2011) 1.16
Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell (2003) 1.15
Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem (2006) 1.14
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A (2011) 1.12
Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol (2011) 1.12
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A (2013) 1.10
TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol (2005) 1.07
Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell (2012) 1.07
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One (2008) 1.05
Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One (2008) 1.01
TRP channels and mice deficient in TRP channels. Pflugers Arch (2005) 1.00
Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett (2010) 0.99
TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol (2011) 0.99
The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol (2013) 0.97
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation (2013) 0.97
Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun (2012) 0.93
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol (2013) 0.92
Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A (2013) 0.92
Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res (2012) 0.92
A STIMulus Package puts orai calcium channels to work. Cell (2009) 0.91
ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A (2011) 0.91
Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One (2012) 0.90
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A (2012) 0.89
Structural characterization of the mouse Girk genes. Gene (2002) 0.88
Sperm patch-clamp. Methods Enzymol (2013) 0.85
Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci (2014) 0.85
The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology (2007) 0.82
The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Mol Cell Neurosci (2008) 0.80
Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. J Neurosci Methods (2002) 0.77