Published in Nat Rev Genet on February 01, 2007
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
Transposable elements and the evolution of regulatory networks. Nat Rev Genet (2008) 6.11
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res (2009) 4.25
A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res (2009) 3.37
MicroRNAs and the advent of vertebrate morphological complexity. Proc Natl Acad Sci U S A (2008) 3.00
Functional shifts in insect microRNA evolution. Genome Biol Evol (2010) 2.94
Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92
Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology. Theory Biosci (2007) 2.89
Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab (2009) 2.85
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC Syst Biol (2010) 2.49
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35
A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions. PLoS One (2009) 2.24
The QTN program and the alleles that matter for evolution: all that's gold does not glitter. Evolution (2011) 2.23
MicroRNA gene evolution in Arabidopsis lyrata and Arabidopsis thaliana. Plant Cell (2010) 2.22
Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biol (2011) 2.21
A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. Clin Sci (Lond) (2010) 2.18
Origins and evolution of eukaryotic RNA interference. Trends Ecol Evol (2008) 2.15
Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis. Nucleic Acids Res (2008) 2.10
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs. Nucleic Acids Res (2010) 2.08
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol (1985) (2010) 2.07
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One (2009) 1.88
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80
MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun (2013) 1.76
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. Blood (2008) 1.71
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66
Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res (2009) 1.64
Birth and expression evolution of mammalian microRNA genes. Genome Res (2012) 1.64
Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res (2009) 1.60
The fate of miRNA* strand through evolutionary analysis: implication for degradation as merely carrier strand or potential regulatory molecule? PLoS One (2010) 1.58
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. PLoS Genet (2011) 1.56
Apomictic and sexual ovules of Boechera display heterochronic global gene expression patterns. Plant Cell (2010) 1.52
Identification of muscle-specific microRNAs in serum of muscular dystrophy animal models: promising novel blood-based markers for muscular dystrophy. PLoS One (2011) 1.52
The evolution and functional diversification of animal microRNA genes. Cell Res (2008) 1.49
Functional and evolutionary analyses of the miR156 and miR529 families in land plants. BMC Plant Biol (2016) 1.49
The role of bZIP transcription factors in green plant evolution: adaptive features emerging from four founder genes. PLoS One (2008) 1.43
A systematic, large-scale comparison of transcription factor binding site models. BMC Genomics (2016) 1.39
Novel functions for small RNA molecules. Curr Opin Mol Ther (2009) 1.39
Construction and analysis of an integrated regulatory network derived from high-throughput sequencing data. PLoS Comput Biol (2011) 1.39
miRNA regulation of cytokine genes. Cytokine (2009) 1.39
Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. PLoS One (2009) 1.35
Sequence variation of MicroRNAs and their binding sites in Arabidopsis. Plant Physiol (2008) 1.35
Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types. Nat Commun (2014) 1.34
Identification of conserved and novel microRNAs that are responsive to heat stress in Brassica rapa. J Exp Bot (2011) 1.33
microRNA control of cell-cell signaling during development and disease. Cell Cycle (2008) 1.32
Identification of differentially expressed microRNAs across the developing human brain. Mol Psychiatry (2013) 1.30
Epigenetic Control of MicroRNA Expression and Aging. Curr Genomics (2009) 1.28
Targeted deletion of miR-182, an abundant retinal microRNA. Mol Vis (2009) 1.28
5' isomiR variation is of functional and evolutionary importance. Nucleic Acids Res (2014) 1.28
Phospho-ΔNp63α is a key regulator of the cisplatin-induced microRNAome in cancer cells. Cell Death Differ (2011) 1.26
MicroRNAs: new players in cardiac injury and protection. Mol Pharmacol (2011) 1.26
MicroRNA processing pathway regulates olfactory neuron morphogenesis. Curr Biol (2008) 1.25
SND1 transcription factor-directed quantitative functional hierarchical genetic regulatory network in wood formation in Populus trichocarpa. Plant Cell (2013) 1.25
MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Mol Pharm (2011) 1.25
Mirtrons: microRNA biogenesis via splicing. Biochimie (2011) 1.24
Epigenetic control of gene expression in the lung. Am J Respir Crit Care Med (2011) 1.24
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Proc Natl Acad Sci U S A (2012) 1.24
MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer. Cancer Res (2008) 1.23
Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle (2012) 1.23
Evidence for the biogenesis of more than 1,000 novel human microRNAs. Genome Biol (2014) 1.23
Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet (2007) 1.23
Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J Biol Chem (2011) 1.22
The genomes of two key bumblebee species with primitive eusocial organization. Genome Biol (2015) 1.21
miRNA-transcription factor interactions: a combinatorial regulation of gene expression. Mol Genet Genomics (2013) 1.21
miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. Oncogene (2010) 1.20
Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One (2013) 1.19
MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease. Cell Cycle (2009) 1.19
The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells. J Nutr (2015) 1.17
Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217. J Biol Chem (2010) 1.16
MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. J Biol Chem (2011) 1.16
Complex degradation processes lead to non-exponential decay patterns and age-dependent decay rates of messenger RNA. PLoS One (2013) 1.15
Regulation of NFATc1 in Osteoclast Differentiation. J Bone Metab (2014) 1.15
Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer. Mol Ther Nucleic Acids (2013) 1.14
Xenopus microRNA genes are predominantly located within introns and are differentially expressed in adult frog tissues via post-transcriptional regulation. Genome Res (2007) 1.14
Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer. Oncotarget (2014) 1.13
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. J Transl Med (2010) 1.13
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. BMC Pharmacol Toxicol (2014) 1.13
Experimental determination of the evolvability of a transcription factor. Proc Natl Acad Sci U S A (2009) 1.12
A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA. Proc Natl Acad Sci U S A (2009) 1.12
MicroRNAs in vascular disease. J Cardiovasc Pharmacol (2011) 1.11
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven. PLoS One (2011) 1.11
Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol (2014) 1.10
Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury. Am J Physiol Renal Physiol (2009) 1.09
Arabidopsis homologs of the petunia hairy meristem gene are required for maintenance of shoot and root indeterminacy. Plant Physiol (2010) 1.08
MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. Mol Cancer (2012) 1.08
MicroRNAs in vascular biology and vascular disease. J Cardiovasc Transl Res (2010) 1.07
Evolution of the human-specific microRNA miR-941. Nat Commun (2012) 1.06
Correlating gene expression variation with cis-regulatory polymorphism in Saccharomyces cerevisiae. Genome Biol Evol (2010) 1.06
An evolutionary perspective of animal microRNAs and their targets. J Biomed Biotechnol (2009) 1.06
Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes. Genome Biol (2008) 1.06
MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines. Int J Biol Sci (2011) 1.06
Expression patterns of intronic microRNAs in Caenorhabditis elegans. Silence (2010) 1.06
Mitochondrial damage-associated molecular patterns and vascular function. Eur Heart J (2014) 1.06
Selection for translation efficiency on synonymous polymorphisms in recent human evolution. Genome Biol Evol (2011) 1.05
MicroRNAs: novel players in cancer diagnosis and therapies. Biomed Res Int (2014) 1.05
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet (2006) 4.34
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell (2004) 4.31
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell (2011) 4.15
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07
Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47
The landscape of C. elegans 3'UTRs. Science (2010) 3.32
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J (2014) 2.47
Conservation of regulatory elements between two species of Drosophila. BMC Bioinformatics (2003) 2.06
doRiNA: a database of RNA interactions in post-transcriptional regulation. Nucleic Acids Res (2011) 2.04
The impact of miRNA target sites in coding sequences and in 3'UTRs. PLoS One (2011) 1.82
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression. Nat Methods (2009) 1.82
Probabilistic clustering of sequences: inferring new bacterial regulons by comparative genomics. Proc Natl Acad Sci U S A (2002) 1.78
A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat Immunol (2004) 1.73
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res (2011) 1.70
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
In vivo and transcriptome-wide identification of RNA binding protein target sites. Mol Cell (2011) 1.47
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J (2012) 1.31
Deciphering the porcine intestinal microRNA transcriptome. BMC Genomics (2010) 1.30
Correlating gene expression variation with cis-regulatory polymorphism in Saccharomyces cerevisiae. Genome Biol Evol (2010) 1.06
SMASHing regulatory sites in DNA by human-mouse sequence comparisons. Proc IEEE Comput Soc Bioinform Conf (2003) 1.01
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. J Clin Invest (2014) 0.99
miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol (2015) 0.98
L(ou)sy miRNA targets? Nat Struct Mol Biol (2006) 0.98
Select microRNAs are essential for early development in the sea urchin. Dev Biol (2011) 0.95
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J (2011) 0.95
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biol (2013) 0.88
Reexamining microRNA site accessibility in Drosophila: a population genomics study. PLoS One (2009) 0.86
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb. Cell (2016) 0.75