Published in EMBO J on December 13, 2011
Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J (2013) 1.02
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest (2014) 1.00
Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PLoS One (2014) 0.90
The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH. Sci Rep (2015) 0.82
Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death Differ (2015) 0.82
DNA Methylation in Basal Metazoans: Insights from Ctenophores. Integr Comp Biol (2015) 0.80
Alterations in gene array patterns in dendritic cells from aged humans. PLoS One (2014) 0.79
Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget (2014) 0.78
Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures. Nucleic Acids Res (2015) 0.78
Gene-expression analysis of gleason grade 3 tumor glands embedded in low- and high-risk prostate cancer. Oncotarget (2016) 0.78
Transcriptional control of stem cell fate by E2Fs and pocket proteins. Front Genet (2015) 0.77
The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa. PLoS Genet (2016) 0.76
TEAD activity is restrained by MYC and stratifies human breast cancer subtypes. Cell Cycle (2016) 0.75
Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas. Theranostics (2017) 0.75
Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells. Sci Rep (2017) 0.75
Rationalising the role of Keratin 9 as a biomarker for Alzheimer's disease. Sci Rep (2016) 0.75
Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes. Open Rheumatol J (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06
Rb targets histone H3 methylation and HP1 to promoters. Nature (2001) 8.26
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev (2000) 6.07
Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell (1998) 4.52
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med (2006) 3.86
Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol (2008) 3.81
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. Mol Cell (2007) 3.59
E2f3 is critical for normal cellular proliferation. Genes Dev (2000) 3.26
Determinants and dynamics of genome accessibility. Nat Rev Genet (2011) 3.15
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev (2002) 3.12
Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev (2001) 2.96
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol (2000) 2.24
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
E2F-associated chromatin modifiers and cell cycle control. Curr Opin Cell Biol (2007) 2.04
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev (2004) 1.97
Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Oncogene (2004) 1.90
Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 1.89
E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol (2004) 1.85
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Genes Dev (2007) 1.71
Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell (2010) 1.59
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Amplification and overexpression of E2F3 in human bladder cancer. Oncogene (2004) 1.52
Mouse development with a single E2F activator. Nature (2008) 1.51
E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol Cell Biol (2003) 1.50
Compensation and specificity of function within the E2F family. Oncogene (2006) 1.48
E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem (2001) 1.44
Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res (2004) 1.40
E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Oncogene (2004) 1.40
LSH cooperates with DNA methyltransferases to repress transcription. Mol Cell Biol (2007) 1.36
Lsh controls Hox gene silencing during development. Proc Natl Acad Sci U S A (2007) 1.31
Inactivation of E2F3 results in centrosome amplification. Cancer Cell (2003) 1.24
Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. Oncogene (2007) 1.22
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol (2003) 1.21
LSH and G9a/GLP complex are required for developmentally programmed DNA methylation. Genome Res (2010) 1.21
E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene (2008) 1.08
E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev (2009) 1.07
Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol (2007) 1.07
Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Res (2003) 1.06
Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol (2010) 0.95
An SNF2 factor involved in mammalian development and cellular proliferation. Dev Dyn (2001) 0.91
Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas. Acta Neuropathol (1999) 0.85
Transcriptional activation of the senescence regulator Lsh by E2F1. Mech Ageing Dev (2011) 0.81
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet (2007) 7.92
Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood (2010) 4.99
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet (2006) 4.34
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell (2004) 4.31
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell (2011) 4.15
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07
Protein production and purification. Nat Methods (2008) 3.97
Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47
The landscape of C. elegans 3'UTRs. Science (2010) 3.32
Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis (2008) 2.78
Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology (2005) 2.78
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res (2009) 2.75
Biochemical and proteomic analysis of the magnetosome membrane in Magnetospirillum gryphiswaldense. Appl Environ Microbiol (2004) 2.74
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J (2002) 2.56
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J (2014) 2.47
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med (2009) 2.28
Novel murine infection models provide deep insights into the "ménage à trois" of Campylobacter jejuni, microbiota and host innate immunity. PLoS One (2011) 2.20
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood (2006) 2.19
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol (2009) 2.17
Conservation of regulatory elements between two species of Drosophila. BMC Bioinformatics (2003) 2.06
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
doRiNA: a database of RNA interactions in post-transcriptional regulation. Nucleic Acids Res (2011) 2.04
Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils. Gastroenterology (2007) 1.98
MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut (2010) 1.93
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition. J Biol Chem (2002) 1.92
Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood (2005) 1.90
Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther (2006) 1.88
Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res (2007) 1.85
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression. Nat Methods (2009) 1.82
The impact of miRNA target sites in coding sequences and in 3'UTRs. PLoS One (2011) 1.82
Wnt signaling in stem and cancer stem cells. Semin Cell Dev Biol (2010) 1.79
Probabilistic clustering of sequences: inferring new bacterial regulons by comparative genomics. Proc Natl Acad Sci U S A (2002) 1.78
Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity (2010) 1.75
A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat Immunol (2004) 1.73
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res (2011) 1.70
Growth-associated protein 43-positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions. Fertil Steril (2007) 1.70
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med (2008) 1.70
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res (2010) 1.66
New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept. J Rheumatol (2008) 1.66
Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther (2011) 1.61
Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circ Res (2008) 1.61
Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol Cell (2009) 1.58
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab. Blood (2010) 1.57
Epigenetic quantification of tumor-infiltrating T-lymphocytes. Epigenetics (2011) 1.57
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell (2010) 1.53
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival. J Transl Med (2007) 1.51
E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell (2002) 1.48
Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet (2012) 1.48
In vivo and transcriptome-wide identification of RNA binding protein target sites. Mol Cell (2011) 1.47
Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography. Radiology (2010) 1.45
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. J Clin Invest (2006) 1.45
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Nucleic Acids Res (2003) 1.45
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity (2002) 1.44
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol Cell Biol (2002) 1.44
Autoregulation of Th1-mediated inflammation by twist1. J Exp Med (2008) 1.43
A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages. J Immunol (2008) 1.43
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43
Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J (2003) 1.40
Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res (2004) 1.40
Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum (2006) 1.38
Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells. Nat Cell Biol (2006) 1.37
Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Mol Cell (2002) 1.36
The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci (2011) 1.35
The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS Biol (2009) 1.31
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J (2012) 1.31
Lsh controls Hox gene silencing during development. Proc Natl Acad Sci U S A (2007) 1.31
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood (2007) 1.31
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One (2010) 1.30
Deciphering the porcine intestinal microRNA transcriptome. BMC Genomics (2010) 1.30
DNA methylation in early development. Mol Reprod Dev (2010) 1.30