Published in Cancer Res on January 15, 2007
Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med (2010) 7.31
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci U S A (2008) 5.18
Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72
Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med (2009) 4.26
Dual roles of Nrf2 in cancer. Pharmacol Res (2008) 3.41
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res (2008) 2.45
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res (2012) 2.07
Regulation of Nrf2-an update. Free Radic Biol Med (2013) 1.81
Nrf2 signaling and cell survival. Toxicol Appl Pharmacol (2009) 1.72
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal (2010) 1.64
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem (2012) 1.49
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene? FASEB J (2012) 1.37
Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res (2010) 1.35
Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res (2015) 1.27
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med (2008) 1.27
Redox control systems in the nucleus: mechanisms and functions. Antioxid Redox Signal (2010) 1.25
Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4. J Immunol (2009) 1.24
Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med (2008) 1.24
Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype. Mol Cancer Ther (2010) 1.21
Mechanism of chemical activation of Nrf2. PLoS One (2012) 1.09
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood (2011) 1.08
Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity. Cell Stress Chaperones (2012) 1.05
Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma. PLoS One (2013) 1.05
Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. J Proteome Res (2008) 1.04
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol (2011) 1.03
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. PLoS One (2011) 1.02
Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone. Mol Cancer Res (2009) 0.99
Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc. J Biol Chem (2008) 0.99
Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med (2015) 0.99
An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance. J Biol Chem (2010) 0.97
Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers (Basel) (2010) 0.94
Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α. PLoS One (2012) 0.92
Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition. J Biol Chem (2012) 0.92
Hydrogen peroxide - production, fate and role in redox signaling of tumor cells. Cell Commun Signal (2015) 0.91
Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci (2010) 0.90
T-cell activation under hypoxic conditions enhances IFN-gamma secretion. Am J Respir Cell Mol Biol (2009) 0.90
Nrf2 target genes are induced under marginal selenium-deficiency. Genes Nutr (2010) 0.87
Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. Int J Exp Pathol (2010) 0.83
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. Antioxid Redox Signal (2013) 0.83
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells. Cancers (Basel) (2010) 0.83
A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics. Mol Cell Proteomics (2016) 0.83
Global gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia. PLoS One (2014) 0.82
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-κB in oral cancer. PLoS One (2014) 0.81
Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin. J Biol Chem (2012) 0.80
Nrf2: bane or blessing in cancer? J Cancer Res Clin Oncol (2014) 0.80
Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. Antioxid Redox Signal (2014) 0.80
Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival. Sci Rep (2013) 0.79
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. Int J Oncol (2013) 0.79
Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells. J Tradit Complement Med (2013) 0.79
The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells. J Cancer Res Clin Oncol (2015) 0.78
The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development. Cancer Lett (2015) 0.77
Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. World J Gastroenterol (2015) 0.77
Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (MSCs) Protected Rats Against Acute Kidney Injury. Adv Pharm Bull (2015) 0.77
Identification and verification of PRDX1 as an inflammation marker for colorectal cancer progression. Am J Transl Res (2016) 0.76
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents. Cancer Res (2016) 0.76
Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. Sci Rep (2016) 0.75
A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation. Br J Pharmacol (2015) 0.75
Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis. Biomed Res Int (2017) 0.75
Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach. J Transl Med (2016) 0.75
The role of peroxiredoxins in cancer. Mol Clin Oncol (2017) 0.75
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis. Oncotarget (2016) 0.75
TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models. Oncotarget (2017) 0.75
dbRIP: a highly integrated database of retrotransposon insertion polymorphisms in humans. Hum Mutat (2006) 4.23
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis. Bioinformatics (2009) 3.05
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta (2002) 2.09
Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ Res (2012) 1.84
Alu retrotransposition-mediated deletion. J Mol Biol (2005) 1.79
Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update. Radiology (2014) 1.78
Genomic rearrangements by LINE-1 insertion-mediated deletion in the human and chimpanzee lineages. Nucleic Acids Res (2005) 1.73
Ras alters epithelial-mesenchymal transition in response to TGFbeta by reducing actin fibers and cell-matrix adhesion. Cell Cycle (2009) 1.70
Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms. Gene (2006) 1.68
Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol (2004) 1.62
Alu recombination-mediated structural deletions in the chimpanzee genome. PLoS Genet (2007) 1.59
Phase Ⅰ clinical study of combination therapy with microwave ablation and cellular immunotherapy in hepatocellular carcinoma. Cancer Biol Ther (2011) 1.57
Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy. Lung Cancer (2004) 1.57
Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Nat Genet (2003) 1.54
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54
The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction. Cancer Biol Ther (2010) 1.46
Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res (2003) 1.44
Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development. Genomics (2008) 1.42
Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2. J Biol Chem (2007) 1.41
Carbon nanotube based 3-D matrix for enabling three-dimensional nano-magneto-electronics [corrected]. PLoS One (2012) 1.40
Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex. Cancer Res (2006) 1.38
Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res (2008) 1.34
Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res (2004) 1.33
Real-time contrast-enhanced ultrasound in diagnosing of focal spleen lesions. Eur J Radiol (2011) 1.31
Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther (2007) 1.30
Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 1.30
Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells. Proc Natl Acad Sci U S A (2005) 1.28
Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down-regulation associated with drug sensitivity. J Biol Chem (2005) 1.27
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J Biol Chem (2006) 1.27
A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: results in ex vivo and in vivo porcine livers. Eur J Radiol (2010) 1.27
Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Mol Cancer Ther (2005) 1.26
Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Gene (2006) 1.26
Identification and characterization of novel polymorphic LINE-1 insertions through comparison of two human genome sequence assemblies. Gene (2006) 1.24
Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers. Nat Commun (2013) 1.23
Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res (2011) 1.22
Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J (2003) 1.21
Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol (2003) 1.18
Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer. Clin Cancer Res (2007) 1.18
Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: a retrospective study. J Gastrointest Surg (2007) 1.16
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One (2011) 1.16
Peroxiredoxin 1 interacts with androgen receptor and enhances its transactivation. Cancer Res (2007) 1.15
Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol Cell Neurosci (2008) 1.15
AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. Cell Signal (2011) 1.14
Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Mol Cancer Ther (2006) 1.14
Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress. Cell Signal (2010) 1.13
Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol Cancer Ther (2005) 1.13
Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J Nutr (2004) 1.11
The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci (2010) 1.10
Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. Clin Cancer Res (2008) 1.10
Hypoxia increases androgen receptor activity in prostate cancer cells. Cancer Res (2006) 1.09
Mechanism of chemical activation of Nrf2. PLoS One (2012) 1.09
Induced pluripotent stem cells as a disease modeling and drug screening platform. J Cardiovasc Pharmacol (2012) 1.09
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08
Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol (2006) 1.08
Expression profiling of archival renal tumors by quantitative PCR to validate prognostic markers. Biotechniques (2007) 1.08
Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Prostate (2006) 1.07
Inhibition of bladder cancer development by allyl isothiocyanate. Carcinogenesis (2009) 1.07
Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations. BMC Genomics (2007) 1.07
Intake of cruciferous vegetables modifies bladder cancer survival. Cancer Epidemiol Biomarkers Prev (2010) 1.06
Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines. Cancer Res (2009) 1.05
Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells. Clin Cancer Res (2005) 1.05
A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae. FEMS Yeast Res (2005) 1.05
Endoplasmic reticulum stress signal mediators are targets of selenium action. Cancer Res (2005) 1.05
The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs (2006) 1.05
Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. J Neurosci (2008) 1.04
Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol (2009) 1.03
A case of wedge resection of duodenum for massive gastrointestinal bleeding due to duodenal metastasis by renal cell carcinoma. World J Surg Oncol (2012) 1.03
Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiation. Radiat Res (2007) 1.02
Comparison of temperature curve and ablation zone between 915- and 2450-MHz cooled-shaft microwave antenna: results in ex vivo porcine livers. Eur J Radiol (2011) 1.01
Distinct patterns of germ-line deletions in MLH1 and MSH2: the implication of Alu repetitive element in the genetic etiology of Lynch syndrome (HNPCC). Hum Mutat (2006) 1.01
Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. BMC Evol Biol (2004) 1.00
Microarray Data Mining for Potential Selenium Targets in Chemoprevention of Prostate Cancer. Cancer Genomics Proteomics (2005) 0.99
Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism. Mol Carcinog (2004) 0.99
Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay. Nutr Cancer (2006) 0.99
Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone. Mol Cancer Res (2009) 0.99
Sustained expression of NADPH oxidase 4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblasts. J Mol Med (Berl) (2010) 0.99
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells. Mol Cancer Ther (2006) 0.99
The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium. Carcinogenesis (2007) 0.98
Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells. Sci Rep (2013) 0.98
Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription. Mol Cancer Ther (2004) 0.98
Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res (2010) 0.98
Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. J Gastroenterol Hepatol (2003) 0.98
Comparison of ablation zone between 915- and 2,450-MHz cooled-shaft microwave antenna: results in in vivo porcine livers. AJR Am J Roentgenol (2009) 0.97
Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer. Cancer Biol Ther (2009) 0.97
Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium. J Mammary Gland Biol Neoplasia (2003) 0.97
Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation. J Biol Chem (2011) 0.97
Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. J Lipid Res (2008) 0.97
Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res (2003) 0.96
Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database. Hum Mutat (2006) 0.96