Published in Nature on January 25, 2007
Targeted chromosomal deletions in human cells using zinc finger nucleases. Genome Res (2009) 6.24
Chromosome territories. Cold Spring Harb Perspect Biol (2010) 5.00
The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol (2009) 3.50
A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. J Cell Biol (2008) 3.39
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
Structure and dynamics of interphase chromosomes. PLoS Comput Biol (2008) 2.07
Higher-order genome organization in human disease. Cold Spring Harb Perspect Biol (2010) 2.03
Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev (2008) 1.62
Higher-order chromatin structure: bridging physics and biology. Curr Opin Genet Dev (2012) 1.60
Locus-specific and activity-independent gene repositioning during early tumorigenesis. J Cell Biol (2008) 1.56
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Estrogen induces global reorganization of chromatin structure in human breast cancer cells. PLoS One (2014) 1.43
Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts. Genome Biol (2010) 1.38
Dynein drives nuclear rotation during forward progression of motile fibroblasts. J Cell Sci (2008) 1.37
Cell biology of the trypanosome genome. Microbiol Mol Biol Rev (2010) 1.27
The effect of translocation-induced nuclear reorganization on gene expression. Genome Res (2010) 1.27
Towards building a chromosome segregation machine. Nature (2010) 1.25
SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions. J Biol Chem (2012) 1.24
Revealing the high-resolution three-dimensional network of chromatin and interchromatin space: a novel electron-microscopic approach to reconstructing nuclear architecture. Chromosome Res (2009) 1.22
The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system. Chromosoma (2009) 1.20
Thermodynamic pathways to genome spatial organization in the cell nucleus. Biophys J (2009) 1.18
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PDGF-BB and TGF-{beta}1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress. Proc Natl Acad Sci U S A (2011) 1.04
Chromosome territories have a highly nonspherical morphology and nonrandom positioning. Chromosome Res (2007) 1.04
The 3D organization of the yeast genome correlates with co-expression and reflects functional relations between genes. PLoS One (2013) 1.04
DNA damage response. Cold Spring Harb Perspect Biol (2011) 1.03
Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. Am J Pathol (2007) 1.02
Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni. Int J Parasitol (2010) 1.02
The properties of genome conformation and spatial gene interaction and regulation networks of normal and malignant human cell types. PLoS One (2013) 1.01
Identifying functional neighborhoods within the cell nucleus: proximity analysis of early S-phase replicating chromatin domains to sites of transcription, RNA polymerase II, HP1gamma, matrin 3 and SAF-A. J Cell Biochem (2008) 0.99
Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. BMC Dev Biol (2009) 0.99
Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation (2010) 0.98
Localization microscopy reveals expression-dependent parameters of chromatin nanostructure. Biophys J (2010) 0.98
A repetitive elements perspective in Polycomb epigenetics. Front Genet (2012) 0.97
Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. PLoS One (2011) 0.96
XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome. Cold Spring Harb Symp Quant Biol (2011) 0.94
Chromosome neighborhood composition determines translocation outcomes after exposure to high-dose radiation in primary cells. Chromosome Res (2007) 0.94
Physiological importance of RNA and protein mobility in the cell nucleus. Histochem Cell Biol (2007) 0.92
Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiol Aging (2008) 0.92
Positioning of human chromosomes in murine cell hybrids according to synteny. Chromosoma (2008) 0.91
A new perspective on transcriptional system regulation (TSR): towards TSR profiling. PLoS One (2008) 0.91
Three-dimensional positioning of genes in mouse cell nuclei. Chromosoma (2008) 0.91
Chromosome positioning from activity-based segregation. Nucleic Acids Res (2014) 0.90
Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin. Cell Cycle (2016) 0.90
The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains. Chromosome Res (2012) 0.89
Chromosome territories reposition during DNA damage-repair response. Genome Biol (2013) 0.89
Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues. BMC Cell Biol (2012) 0.89
DNA in motion during double-strand break repair. Trends Cell Biol (2013) 0.88
Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation. Nucleic Acids Res (2008) 0.88
Chromosome conformation capture uncovers potential genome-wide interactions between human conserved non-coding sequences. PLoS One (2011) 0.88
Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. Eur Biophys J (2009) 0.86
Mechanics and dynamics of X-chromosome pairing at X inactivation. PLoS Comput Biol (2008) 0.85
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Are we degenerate tetraploids? More genomes, new facts. Biol Direct (2008) 0.84
Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship? Mol Cytogenet (2009) 0.84
Genomics and the immune system. Immunology (2008) 0.84
Gene density and chromosome territory shape. Chromosoma (2014) 0.83
Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization. Hum Genet (2014) 0.83
Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. J Cell Biochem (2016) 0.82
Hierarchical radial and polar organisation of chromosomes in human sperm. Chromosome Res (2012) 0.82
Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus. Chromosoma (2012) 0.82
Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development. PLoS One (2012) 0.81
Positioning of chromosome 15, 18, X and Y centromeres in sperm cells of fertile individuals and infertile patients with increased level of aneuploidy. Chromosome Res (2008) 0.81
Spatial organization of genes as a component of regulated expression. Chromosoma (2009) 0.80
Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells. Chromosome Res (2015) 0.80
Statistical Test of Expression Pattern (STEPath): a new strategy to integrate gene expression data with genomic information in individual and meta-analysis studies. BMC Bioinformatics (2011) 0.80
Genomic Architecture may Influence Recurrent Chromosomal Translocation Frequency in the Igh Locus. Front Immunol (2013) 0.79
The architecture of functional neighborhoods within the mammalian cell nucleus. Adv Enzyme Regul (2009) 0.79
Higher-order genomic organization in pluripotent stem cells. Protein Cell (2012) 0.79
Interplay of ribosomal DNA loci in nucleolar dominance: dominant NORs are up-regulated by chromatin dynamics in the wheat-rye system. PLoS One (2008) 0.79
Polymer models of interphase chromosomes. Nucleus (2014) 0.79
Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α. PLoS One (2013) 0.78
Efficiency in Complexity: Composition and Dynamic Nature of Mimivirus Replication Factories. J Virol (2016) 0.78
Reorganization of the interchromosomal network during keratinocyte differentiation. Chromosoma (2015) 0.78
Continued stabilization of the nuclear higher-order structure of post-mitotic neurons in vivo. PLoS One (2011) 0.78
IMACULAT - an open access package for the quantitative analysis of chromosome localization in the nucleus. PLoS One (2013) 0.78
PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells. Sci Rep (2016) 0.78
Genomic positions of co-expressed genes: echoes of chromosome organisation in gene expression data. BMC Res Notes (2013) 0.78
Mapping chromatin conformation. F1000 Biol Rep (2010) 0.78
Spatial organization of transcription machinery and its segregation from the replisome in fast-growing bacterial cells. Nucleic Acids Res (2014) 0.78
Combined fluorescent-chromogenic in situ hybridization for identification and laser microdissection of interphase chromosomes. PLoS One (2013) 0.77
The elusive quest for RNA knots. RNA Biol (2016) 0.77
Chromatin diminution in Copepoda (Crustacea): pattern, biological role and evolutionary aspects. Comp Cytogenet (2014) 0.76
Impact of sperm DNA chromatin in the clinic. J Assist Reprod Genet (2015) 0.76
Nuclear architecture and gene silencing in olfactory sensory neurons. Bioarchitecture (2014) 0.76
Organizational heterogeneity of vertebrate genomes. PLoS One (2012) 0.76
Evidence of genetic instability in tumors and normal nearby tissues. PLoS One (2010) 0.75
Distinct and shared three-dimensional chromosome organization patterns in lymphocytes, monoclonal gammopathy of undetermined significance and multiple myeloma. Int J Cancer (2016) 0.75
Large-scale probabilistic 3D organization of human chromosome territories. Hum Mol Genet (2015) 0.75
Genetic and epigenetic control of the spatial organization of the genome. Mol Biol Cell (2017) 0.75
The nuclear envelope as a mechanostat: a central cog in the machinery of cell and tissue regulation? Bonekey Rep (2014) 0.75
Influence of the Solvent Quality on Ring Polymer Dimensions. Macromolecules (2015) 0.75
DNA loci cross-talk through thermodynamics. J Biomed Biotechnol (2009) 0.75
Colocalization of multiple DNA loci: a physical mechanism. Biophys J (2012) 0.75
AAGAG repeat RNA is an essential component of nuclear matrix in Drosophila. RNA Biol (2013) 0.75
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature (2002) 19.77
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature (2011) 10.77
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
Lamin A-dependent nuclear defects in human aging. Science (2006) 6.71
Global transcription in pluripotent embryonic stem cells. Cell Stem Cell (2008) 5.81
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A (2003) 5.59
Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol (2006) 5.18
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med (2005) 5.01
Epigenetics in alternative pre-mRNA splicing. Cell (2011) 4.74
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
A kinetic framework for a mammalian RNA polymerase in vivo. Science (2002) 4.42
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol (2004) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
Transcription dynamics. Mol Cell (2009) 4.15
Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet (2003) 3.91
Activation of the cellular DNA damage response in the absence of DNA lesions. Science (2008) 3.17
Measurement of dynamic protein binding to chromatin in vivo, using photobleaching microscopy. Methods Enzymol (2004) 3.02
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol (2008) 2.93
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Proc Natl Acad Sci U S A (2008) 2.58
Tissue-specific spatial organization of genomes. Genome Biol (2004) 2.57
Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.53
Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol (2009) 2.40
Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus. J Cell Sci (2006) 2.37
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol (2004) 2.33
Chromosome positioning in the interphase nucleus. Trends Cell Biol (2002) 2.32
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature (2007) 2.30
The meaning of gene positioning. Cell (2008) 2.16
Functional implications of genome topology. Nat Struct Mol Biol (2013) 2.13
Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol (2006) 2.12
HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med (2004) 1.97
Spatial dynamics of chromosome translocations in living cells. Science (2013) 1.95
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nat Struct Mol Biol (2006) 1.94
In vivo kinetics of Cajal body components. J Cell Biol (2004) 1.91
Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins. J Cell Biol (2004) 1.86
The lamin protein family. Genome Biol (2011) 1.85
Functional association of Sun1 with nuclear pore complexes. J Cell Biol (2007) 1.81
Human chromokinesin KIF4A functions in chromosome condensation and segregation. J Cell Biol (2004) 1.81
Competition between histone H1 and HMGN proteins for chromatin binding sites. EMBO Rep (2002) 1.74
Biogenesis of nuclear bodies. Cold Spring Harb Perspect Biol (2010) 1.69
Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev (2008) 1.62
In vitro generation of human cells with cancer stem cell properties. Nat Cell Biol (2011) 1.61
Quantitation of GFP-fusion proteins in single living cells. J Struct Biol (2002) 1.59
Conservation of relative chromosome positioning in normal and cancer cells. Curr Biol (2002) 1.58
Locus-specific and activity-independent gene repositioning during early tumorigenesis. J Cell Biol (2008) 1.56
The road much traveled: trafficking in the cell nucleus. Curr Opin Cell Biol (2006) 1.52
A cyclophilin functions in pre-mRNA splicing. EMBO J (2002) 1.49
Modulation of RNA polymerase assembly dynamics in transcriptional regulation. Mol Cell (2008) 1.47
Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. J Biol Chem (2002) 1.45
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A (2009) 1.44
Chromokinesins: multitalented players in mitosis. Trends Cell Biol (2005) 1.41
Spatial genome organization. Exp Cell Res (2004) 1.39
LINC complexes in health and disease. Nucleus (2011) 1.37
Mobility and immobility of chromatin in transcription and genome stability. Curr Opin Genet Dev (2007) 1.37
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J Cell Biol (2009) 1.36
Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs. Mol Cell (2002) 1.30
In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin. Mol Cell Biol (2004) 1.26
Potential roles for ubiquitin and the proteasome during ribosome biogenesis. Mol Cell Biol (2006) 1.25
An uncertainty principle in chromosome positioning. Trends Cell Biol (2003) 1.19
Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins. Nucleus (2011) 1.19
More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation. Curr Opin Genet Dev (2011) 1.18
Eliminating the impact of the Impact Factor. J Cell Biol (2013) 1.15
Identification of differential protein interactors of lamin A and progerin. Nucleus (2010) 1.14
Disease-specific gene repositioning in breast cancer. J Cell Biol (2009) 1.13
Nucleolomics: an inventory of the nucleolus. Mol Cell (2002) 1.10
Recruitment of dioxin receptor to active transcription sites. Mol Biol Cell (2002) 1.08
The central role of chromatin maintenance in aging. Aging (Albany NY) (2009) 1.07
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett (2009) 1.06
Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer. Mol Biol Cell (2005) 1.05
Systems biology in the cell nucleus. J Cell Sci (2005) 1.04
A non-random walk through the genome. Genome Biol (2005) 1.04
New tools for JCB. J Cell Biol (2011) 1.01
Mapping of lamin A- and progerin-interacting genome regions. Chromosoma (2012) 1.01
Measuring dynamics of nuclear proteins by photobleaching. Curr Protoc Cell Biol (2003) 1.01
Friends, colleagues, authors, lend us your data. J Cell Biol (2010) 1.00
SnapShot: Chromosome confirmation capture. Cell (2012) 1.00
Genome instability in progeria: when repair gets old. Nat Med (2005) 0.99
The JCB DataViewer scales up. J Cell Biol (2012) 0.98
Tumor formation via loss of a molecular motor protein. Curr Biol (2006) 0.97
Non-coding RNAs in DNA damage and repair. FEBS Lett (2013) 0.97
Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle. Exp Cell Res (2005) 0.95
The cell nucleus and aging: tantalizing clues and hopeful promises. PLoS Biol (2005) 0.95
Cell biology: Nuclear order out of chaos. Nature (2008) 0.93
On the contribution of spatial genome organization to cancerous chromosome translocations. J Natl Cancer Inst Monogr (2008) 0.92
Automatic segmentation and supervised learning-based selection of nuclei in cancer tissue images. Cytometry A (2012) 0.91
Genomes, proteomes, and dynamic networks in the cell nucleus. Histochem Cell Biol (2002) 0.91
Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. PLoS Biol (2005) 0.90
A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines. Oncotarget (2013) 0.89
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett (2011) 0.89
DNA damage, chromatin, and transcription: the trinity of aging. Curr Opin Cell Biol (2012) 0.88
H1FOO is coupled to the initiation of oocytic growth. Biol Reprod (2004) 0.88
Automatic nuclei segmentation and spatial FISH analysis for cancer detection. Conf Proc IEEE Eng Med Biol Soc (2009) 0.88
Splicing misplaced. Cell (2005) 0.88
Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning. BMC Bioinformatics (2012) 0.87