PubRank

Gunnar Pejler

Author PubWeight™ 73.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mast cells can enhance resistance to snake and honeybee venoms. Science 2006 2.72
2 A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem 2004 1.70
3 Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation 2009 1.43
4 Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A 2009 1.34
5 The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J Exp Med 2003 1.34
6 Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem 2004 1.32
7 Intracellular proteoglycans. Biochem J 2004 1.25
8 Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med 2008 1.23
9 A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood 2010 1.20
10 Neutrophil elastase depends on serglycin proteoglycan for localization in granules. Blood 2007 1.16
11 Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 2011 1.16
12 Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J Immunol 2009 1.15
13 Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med 2004 1.11
14 Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol 2011 1.11
15 Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem 2005 1.09
16 Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan. J Allergy Clin Immunol 2008 1.07
17 Biology of mast cell tryptase. An inflammatory mediator. FEBS J 2006 1.06
18 Biological implications of preformed mast cell mediators. Cell Mol Life Sci 2010 1.06
19 Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem 2004 1.05
20 Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem 2007 1.04
21 Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem J 2007 1.03
22 Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem 2006 1.02
23 Serglycin: the master of the mast cell. Methods Mol Biol 2012 1.01
24 Human mast cell beta-tryptase is a gelatinase. J Immunol 2003 0.99
25 Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol 2010 0.97
26 Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem 2010 0.96
27 Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J 2008 0.96
28 The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol 2010 0.95
29 Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. J Biol Chem 2003 0.95
30 A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J 2006 0.94
31 Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood 2007 0.93
32 The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol 2012 0.92
33 Mast cell proteoglycans. J Histochem Cytochem 2012 0.92
34 Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol Chem 2002 0.91
35 Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J Biol Chem 2002 0.91
36 A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci 2005 0.90
37 Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem 2003 0.90
38 Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One 2010 0.89
39 Vitamin a is a negative regulator of osteoblast mineralization. PLoS One 2013 0.89
40 Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J Immunol 2008 0.88
41 Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases. J Immunol 2009 0.87
42 Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS One 2011 0.86
43 Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors. PLoS One 2009 0.86
44 Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem 2011 0.86
45 A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J Biol Chem 2010 0.86
46 Infection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response. Infect Immun 2009 0.85
47 Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation. Mol Immunol 2011 0.85
48 Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase. J Mol Biol 2005 0.85
49 Formation of active monomers from tetrameric human beta-tryptase. Biochem J 2003 0.84
50 Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo. Immunology 2014 0.84
51 Histidines are critical for heparin-dependent activation of mast cell tryptase. J Immunol 2004 0.84
52 Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice. J Leukoc Biol 2008 0.83
53 Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cells. J Biol Chem 2012 0.82
54 Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase. Mol Immunol 2010 0.82
55 Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol 2012 0.82
56 Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol 2014 0.82
57 Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol Chem 2006 0.82
58 Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis. Biol Chem 2012 0.81
59 Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J 2012 0.81
60 Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol 2011 0.81
61 Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett 2004 0.81
62 Active caspase-3 is stored within secretory compartments of viable mast cells. J Immunol 2013 0.80
63 ADAMTS: novel proteases expressed by activated mast cells. Biol Chem 2013 0.79
64 Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells. Mol Immunol 2008 0.79
65 Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules. Eur J Cell Biol 2009 0.78
66 Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction. Kidney Int 2013 0.78
67 The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy. Plast Reconstr Surg 2014 0.78
68 Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B. Pancreatology 2006 0.78
69 Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas. Breast Cancer Res Treat 2008 0.78
70 Tumor-mast cell interactions: induction of pro-tumorigenic genes and anti-tumorigenic 4-1BB in MCs in response to Lewis Lung Carcinoma. Mol Immunol 2012 0.78
71 Distorted secretory granule composition in mast cells with multiple protease deficiency. J Immunol 2013 0.77
72 Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. Biol Chem 2012 0.77
73 Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol 2014 0.77
74 Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation. Infect Immun 2013 0.77
75 Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1. J Pharmacol Exp Ther 2013 0.76
76 Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease. J Biol Chem 2014 0.76
77 Diverse bone morphogenetic protein expression profiles and smad pathway activation in different phenotypes of experimental canine mammary tumors. PLoS One 2009 0.75
78 Polycationic peptides as inhibitors of mast cell serine proteases. Biochem Pharmacol 2003 0.75
79 Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol 2014 0.75
80 Induction of mast cell apoptosis by a novel secretory granule-mediated pathway. Methods Mol Biol 2015 0.75